Double-Blind Comparison of a Single Dose and a Five-Day Course of Metronidazole in the Treatment of Trichomoniasis

Thin, R N; Symonds, Merle; Booker, Reanne; Cook, Shelly; Langley, F.

doi:10.1097/00006254-198009000-00022

Cited by 10 publications

(10 citation statements)

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“…Tinidazole is generally more expensive, reaches higher levels in serum and the genitourinary tract, has a longer half-life than metronidazole (12.5 hours versus 7.3 hours), and has fewer gastrointestinal side effects (676)(677)(678). In randomized clinical trials, recommended metronidazole regimens have resulted in cure rates of approximately 84%-98% (679)(680)(681), and the recommended tinidazole regimen has resulted in cure rates of approximately 92%-100% (680,(682)(683)(684)(685). Randomized controlled trials comparing single 2 g doses of metronidazole and tinidazole suggest that tinidazole is equivalent or superior to metronidazole in achieving parasitologic cure and resolution of symptoms (686).…”

Section: Trichomoniasismentioning

confidence: 99%

Sexually Transmitted Diseases Treatment Guidelines, 2006

Workowski¹,

Levine²

2006

PsycEXTRA Dataset

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These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 30-May 2, 2013. The information in this report updates the Sexually Transmitted Diseases Treatment Guidelines, 2010 (MMWR Recomm Rep 2010;59 [No. RR-12]). These updated guidelines discuss 1) alternative treatment regimens for Neisseria gonorrhoeae; 2) the use of nucleic acid amplification tests for the diagnosis of trichomoniasis; 3) alternative treatment options for genital warts; 4) the role of Mycoplasma genitalium in urethritis/cervicitis and treatment-related implications; 5) updated HPV vaccine recommendations and counseling messages; 6) the management of persons who are transgender; 7) annual testing for hepatitis C in persons with HIV infection; 8) updated recommendations for diagnostic evaluation of urethritis; and 9) retesting to detect repeat infection. Physicians and other health-care providers can use these guidelines to assist in the prevention and treatment of STDs.

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Section: Trichomoniasismentioning

confidence: 99%

Sexually Transmitted Diseases Treatment Guidelines, 2006

Workowski¹,

Levine²

2006

PsycEXTRA Dataset

560

1,009

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“…Single dose treatments are associated with more frequent side effects than longer oral treatment. Standard treatments are a 5 to 7 day course of metronidazole 400 to 500 mg twice daily or 2g of metronidazole or tinidazole as single dose [49,50].…”

Section: Treatmentmentioning

confidence: 99%

Trichomonas vaginalis origins, molecular pathobiology and clinical considerations

Hirt

Sherrard²

2015

Current Opinion in Infectious Diseases

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“…Oral single dose treatment with metronidazole seems to be effective in achieving short-term parasitological cure but is associated with more frequent side-effects than either longer oral or intravaginal treatment. It must, however, be noted that the drop-out rates (between 30 and 62%) were most significant in two of the short vs. long treatment trials (Thin et al 1979;Hager et al 1980), and the results of this comparison should be interpreted with caution. Intravaginal treatment showed parasitological cure rates around 50%, which is unacceptably low.…”

Section: Discussionmentioning

confidence: 93%

Trichomoniasis treatment in women: a systematic review

Gülmezoglu

Garner

1998

Tropical Med Int Health

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SummaryOBJECTIVE To compare the effectiveness of various treatment strategies for trichomoniasis in women. DATA SOURCES Medline from 1966 to1996, Embase from 1986 to 1996, Science Citation Index from 1990 to 1996; reference lists of existing reviews; through the manufacturers of metronidazole and tinidazole in the UK, the Cochrane Controlled Trials Register until October 1997 and informal discovery. STUDY SELECTION Any randomized or quasi-randomized trial in nonpregnant women with trichomoniasis where different treatment strategies were compared. 45 of the 124 identified studies met the criteria and were included in the review. DATA EXTRACTION Settings, diagnostic methods, exclusions, loss to follow-up and partner treatment strategies were extracted. Outcomes sought were parasitological cure, clinical cure and side-effects of treatment. RESULTS Most trials were small, with only two trials containing more than 100 women in each comparison group. Only 11 trials followed up women for more than one month. Oral nitroimidazoles were effective in achieving parasitological cure. Fourteen trials compared different treatment strategies with the remainder comparing different doses or different drugs. Partner treatment was effective in decreasing longer-term reinfection rates in the one trial testing this. CONCLUSIONS Parasitological cure can be achieved by a single oral dose of nitroimidazoles. There is, however, very little data on partner treatment strategies and long-term cure rates after initial treatment. Further research should test various partner treatment strategies to prevent re-infections and reduce trichomoniasis prevalence.keywords Trichomonas vaginalis, nitroimidazoles, systematic review

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Double-Blind Comparison of a Single Dose and a Five-Day Course of Metronidazole in the Treatment of Trichomoniasis

Cited by 10 publications

References 0 publications

Sexually Transmitted Diseases Treatment Guidelines, 2006

Sexually Transmitted Diseases Treatment Guidelines, 2006

Trichomonas vaginalis origins, molecular pathobiology and clinical considerations

Trichomoniasis treatment in women: a systematic review

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