Double-blind comparison of 200-mg ketoconazole oral tablets and 1200-mg miconazole vaginal capsule in the treatment of vaginal candidosis

Meijden, W I van der; Hoek, J. C. S. van der; Staal, Hans J.M.; Joost, Theodoor van; Stolz, E.

doi:10.1016/0028-2243(86)90057-2

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…The Centers for Disease Control and Prevention recommend two doses of oral fluconazole 150 mg to treat SVVC [3]. Several studies have demonstrated that uncomplicated VVC responds well to a single dose of miconazole nitrate vaginal suppository 1,200 mg [4,5,6,7,8,9]. The effect of miconazole nitrate vaginal suppository 1,200 mg on SVVC is not known.…”

Section: Introductionmentioning

confidence: 99%

Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis

Fan

Liu²,

Liang³

2015

Gynecol Obstet Invest

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Aims: Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). Methods: In this prospective, randomized case control study, 577 cases of consecutive patients with SVVC were studied at the Gynecological Clinic of Peking University Shenzhen Hospital from January 1, 2009 through December 31, 2010. Patients with SVVC were treated with two doses of miconazole nitrate vaginal suppository 1,200 mg or two doses of fluconazole 150 mg. The patients were followed up for 7-14 and 30-35 days following the second dose of therapy. Results: The mycological cure rates of the patients on days 7-14 of follow-up were 75.9% (220/290) and 84.0% (241/287) in the miconazole and fluconazole groups, respectively (p < 0.05). The mycological cure rates of the patients at the second follow-up were 64.8% (188/290) and 69.7% (200/287), respectively, in the two groups (p > 0.05). Conclusion: The study demonstrated that two doses of miconazole nitrate vaginal suppository 1,200 mg were as effective as two doses of an oral fluconazole 150 mg regimen in the treatment of patients with SVVC.

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Section: Introductionmentioning

confidence: 99%

Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis

Fan

Liu²,

Liang³

2015

Gynecol Obstet Invest

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“…Certain morbidities are associated with high rates of Candida vulvovaginintis like hypothyroidism, diabetes, autoimmune disorders like system lupus and other autoimmune conditions. 10,11 Chronic mental stress or emotional stress also may alter immunity in the form of reduction of the total count and functions of natural killer cells that is a major immune cell that scan and kill fungal infections. 12 Local treatment may be irritant to many patients and those types of cases requested the oral treatment also oral treatment is a good choice for virgins, the discovery of azole groups solved many of these problems like ketoconazole but it is limited by its hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Oral itraconazole combined with local isoconazole in the treatment chronic candida vulvovaginitis

El-Sayed

2022

Int J Reprod Contracept Obstet Gynecol

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Background: Chronic vulvovaginal candidiasis is a major problem and common with poor quality of life from itching and discharge and it is difficult to treat because fungi are slow growers.Methods: Two hundred cases recruited from JAM clinic in Benha city, Egypt divided into two groups to study combination of oral itraconazole and local isoconazole in comparison with the use of local isoconazole only in chronic monilial vulvovaginitis and main outcome was relief of symptoms and signs with absent laboratory evidence of monilial infection by culture. Group one included 100 cases treated with combined oral itraconazole with three alternate days dose of local isoconazole (gynotrazonagen) and group two (local isoconazole only) included 100 cases treated with local isoconazole ovules on alternate days for 3 doses and week period.Results: Regarding the cure rate there were 90 clinically cured rate in the combined group compared to 70 in the local treatment group with p value of 0.0004 which was a very high statistically significant difference. Clinical cure included alleviation of the symptoms of discharge dysuria dyspareunia burning itching with also by clinical examination cure and disappearance of redness erythema edema fissures with absent pseudomycelia by microscopic examination. Usually, a symptom score of less than 2 is a positive one. Regarding the laboratory cure which means absent or negative candida culture on Sabaraud agar medium there were a laboratory cure rate of 84 out of 100 in the combined treatment group compared to 65 out of 100 in the local treatment group with p value of 0.002 and a high statistically significant difference.Conclusions: Oral itraconazole combined with local isoconazole is highly effective in treating chronic monilial vulvovaginitis.

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Therapeutic Considerations in Fungal Vaginitis

Sobel¹

1990

Chemotherapy of Fungal Diseases

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Double-blind comparison of 200-mg ketoconazole oral tablets and 1200-mg miconazole vaginal capsule in the treatment of vaginal candidosis

Cited by 5 publications

References 8 publications

Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis

Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis

Oral itraconazole combined with local isoconazole in the treatment chronic candida vulvovaginitis

Therapeutic Considerations in Fungal Vaginitis

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