Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis

S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]

“…This is consistent with prior conclusions by di Padova [15]. However, it does not clearly explain findings of several previously published small studies [28][29][30][31]. These studies although limited to 1 month of duration, reported equivalent effectiveness to NSAIDs in relieving symptoms of OA.…”

The Role of Chondroprotectants, Nutraceuticals, and Nutrition in Rehabilitation

“…Recent evidence supports the theory that excessive production of free radicals or the imbalance between concentrations of free radicals and antioxidant defenses may be related to processes such as aging, cancer, diabetes mellitus, lupus, and arthritis. In controlled trials of humans with osteoarthritis, SAMe was as effective as nonsteroidal antiinflammatory drugs (NSAIDs) and better than placebo in reducing pain and improving function with a lower likelihood of side effects [91][92][93][94][95][96][97][98] ; however, no difference with an NSAID drug was found in one study. 89 Thus antioxidant therapy may be of benefit in the treatment of osteoarthritis.…”

Nutrition and Rheumatic Disease

“…Trials of S-adenosylmethionine also have had apparently positive results, albeit somewhat limited by adverse effects and high dropout rates (198)(199)(200)(201)(202)(203). A ginger-derived product has also been tested in a trial that had moderately positive results (204).…”

“…Cytokines,12 beneficial effects of,198 and rheumatic diseases, 12 role of, 62 Cytoplasmic (c-ANCA), 9Daily energy expenditure, total (TEE), 117 Dermatomyositis/polymyositis,7,[195][196][197][198][199][200][201][202][203][204][205][206][207][208] balanced diet, intake of,200-206 creatine supplement and physical exercise, 201, 202-203 supplements with calcium and vitamin D, 205-206 to reduce risk of steroid-induced osteoporosis, 205-206 Descriptive studies (cross-sectional), epidemiological study designs, 41, 42 Devil's claw (Harpagophytum Procumbens), 102 efficacy in OA, 102 Diacerein, 144-145 Diagnosis of SS, 235 Diagnostic tests of SS, 235 Dietary assessment, 16, 24-25 Dietary fat intake and SLE, 161 herbal supplements, 101-106 vitamins, 97-101 Diet programs, popular, 176 Diets and SLE, low-protein, 160 Diets, special, 90 Disease incidence, 42 Disease-modifying anti-rheumatic drug (DMARD), 57-58, 114, 260 drugs for RA, 65 Disease prevalence, 42 Diseases affecting elderly OA -most prevalant, 126 Diuretics, 172 DMARD, see Disease-modifying anti-rheumatic drug (DMARD) Double-stranded DNA (dsDNA), 5 Drug absorption and bioavailability, 58 Drug-induced vasculitides, 219 causative drugs, 219 Drug-nutrient interactions in rheumatic diseases, 57-58 cytokine antagonists anti-TNF--based therapies, 62 modulation of proinflammatory cytokines by n-3 fatty acid supplementation, 62-63 proinflammatory cytokines in pathogenesis of rheumatic diseases, role of, 62 disease-modifying anti-rheumatic drugs, 63 folate status and supplementation in methtotrexate treatment, 63-64 interaction of glutamine with methotrexate, 64 nutritional status and dietary management, 64 importance, 57 mechanisms of, 58 biological mediators of rheumatic diseases by nutrients, modulation of, 58 nutritional status by drugs, change in, 58 pharmacokinetics by food, alteration of, 58 nonsteroidal anti-inflammatory drugs, 59 arachidonic acid metabolism and prostaglandin production, 59-61 clinical benefits of n-3 fatty acids in rheumatoid arthritis, 61 concomitant food intake on bioavailability of NSAIDs, effects of, 59 impact of vitamin E in rheumatoid arthritis, 61-62 recommendations, 66 Dry eye test of SS, 235 DsDNA antibodies, 6 Dual-energy X-ray absorptiometry (DEXA), 16 Fatty acids, 205 clinical trials of, supplementation, 161 modulates immune system, 161 role in energy metabolism, 93 Feverfew (Tanacetum parthenium), 104 increased bleeding time, 104 Fibromyalgia, 35 alleviation of symptoms using vegetarian diets, 184 Chlorella pyrenoidosa for treatment, 189 diagnosis, 184 and diet, 183-184 discussion, 190-191 dietary recommendations, 191-192 advice to patients, 191 dietary supplementation, 191-192 dietary treatment, 184 frequency, 90 gastrointestinal (GI) symptoms and, 183 higher substance P levels in patients, 185 increasing incidence with age, 183 lower growth hormon...…”