Double-Blind Clinical Trial to Compare Autologous Fat Grafts versus Autologous Fat Grafts with PDGF

Abstract

Therapeutic, II.

Platelet-Rich Plasma Influences Expansion and Paracrine Function of Adipose-Derived Stromal Cells in a Dose-Dependent Fashion

“…It is generally accepted that the growth factors present in platelet-rich plasma, presumed to be in high concentration also, stimulate wound healing, 34,35 tissue remodeling, and revascularization 21 and improve lipograft take. 15,17,19 Clinical evaluation studies on the use of platelet-rich plasma, however, report a large variation of results, [18][19][20] which might be attributable to interindividual variations in the composition of platelet-rich plasma-lipograft mixtures. Different concentrations of platelet-rich plasma have been shown to induce varying effects on fibroblasts, osteoblasts, and endothelial cells.…”

“…Moreover, addition of platelet-rich plasma to fat grafts reduces the occurrence of oil cysts. 17 However, the clinical efficacy of the use of platelet-rich plasma is highly variable, [18][19][20] which causes doubt about the benefit of platelet-rich plasma to support and improve graft take. 21 From a pharmacologic point of view, it is to be expected that platelet-rich plasma would act in a dose-dependent fashion in combination with lipofilling.…”

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

“…A growing number of people are chasing for youthful and beautiful appearance, which urges them to choose plastic surgery. As multiple previous trials analyzed, Rigotti et al proved that using PRP alone has no advantage in adipogenesis and there is no need to add PRP to the adipose tissue graft for a better result. And PRF seemed to be more effective than PRP when combined with fat graft during facial lipostructure, which may be because of the strong fibrin matrix with a complex 3‐dimensional architecture that can last for a long period after application .…”

Platelet-Rich Plasma for the Aesthetic Surgeon

“…44 In a separate study of 49 patients with HIV-associated facial fat atrophy, randomized to receive an autologous fat injection with or without PRP, no difference was seen at 12 months by both radiographic and photographic measurements. 45 However, other investigation has shown a potential positive effect with improved volume retention and subjective patient-reported outcomes with decreased revision rates. 46 Decreased ecchymosis and maintenance of volume has also been shown with combining PRFM.…”