Double benefit of metformin treatment: improved bladder function in cyclophosphamide-induced cystitis and enhanced cytotoxicity in cancer cells

Engin, Seçkin; Barut, Elif Nur; Soysal, Aysun Çelik; Keskin, Oğuzhan; Keri̇moğlu, Gökçen; Kadıoğlu, Mine; Sezen, Sena F.

doi:10.1007/s00210-021-02055-9

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…With regard 907 to metformin effect on the bladder contractility, there were only few meeting reports and there was insufficient studies on the mechanism of action of metformin on the urinary bladder of rats. [9,10,11]. Studied that differential effects of metformin in rats' urinary bladder and other different tissues.…”

Section: Discussionmentioning

confidence: 99%

“…When TNF-α was applied to these cells with metformin, it was shown that they improved diabetic bladder dysfunction with together. In a study on the effects of cyclophosphamide and metformin on bladder dysfunction, it was revealed that metformin partially inhibited cycloffamide-induced cystitis [10]. When cyclophosphamide and metformin were combined, increased cytotoxicity was observed.…”

Section: Discussionmentioning

confidence: 99%

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Are C-reactive protein, neutrophil to lymphocyte, platelet to lymphocyte ratios, and mean platelet volume related to the severity of idiopathic carpal tunnel syndrome?

Altun¹

2022

Ann Med Res

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Aim: The aim of this study was to investigate the correlation of C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with idiopathic carpal tunnel syndrome (CTS). Methods: One hundred patients with CTS and 60 control subjects were included in this study. Medical records and laboratory findings of the participants were analyzed retrospectively between March 2019 and February 2020. Laboratory result values obtained from the members included in the study were examined. Results: There was a correlation between CRP and the severity of CTS (p<0.01). There was also a positive correlation between CRP and symptom severity scale (p<0.01) and functional status scale (p<0.01). No statistically significant changes were observed in the measurements of blood values other than CRP in the patients. Conclusions: In this study, a relationship was found between CRP, one of the hematological parameters, and the presence or severity of CTS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Are C-reactive protein, neutrophil to lymphocyte, platelet to lymphocyte ratios, and mean platelet volume related to the severity of idiopathic carpal tunnel syndrome?

Altun¹

2022

Ann Med Res

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“…Cyclophosphamide (CYP), an oxazaphosphorine alkylating agent, was first successfully prepared by Norbert Brock in 1985 [1]. CYP is a prodrug that is widely used in the treatment of various malignancies and autoimmune diseases [2,3]. After administration, CYP is metabolized to 4hydroxycyclophosphamide in hepatocytes, and then enters the target cell for conversion to alkylated phosphoramide mustard, interfering with DNA replication and causing cell death [2,4].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the treatment of Mesna may cause adverse reactions, such as ST segment elevation and asthenia [13]. Therefore, a more effective and safer strategy is needed to prevent bladder toxicity following CYP management [3].…”

Section: Introductionmentioning

confidence: 99%

Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury

Qiu¹,

Li²,

Huang³

et al. 2022

Biomed. Mater.

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Clinical management of cyclophosphamide (CYP) results in numerous side effects including hemorrhagic cystitis (HC), which is characterized by inflammation and oxidative stress damage. Intravesical hyaluronic acid (HA) supplementation, a therapeutic method to restore barrier function of bladder, avoid the stimulation of metabolic toxicants on bladder and reduce inflammatory response, has shown good results in acute or chronic bladder diseases. However, there are unmet medical needs for the treatment of HC to temporarily restore bladder barrier and reduce inflammation. Herein, sulfhydryl functionalized HA (HA-SH) and dimethyl sulfoxide (DMSO) were used to prepared a hydrogel system for optimizing the treatment of HC. We systematically evaluated the physicochemical of hydrogels and their roles in a rat model of CYP-induced HC. The prepared hydrogels exhibited outstanding gel forming properties, injectability, and biosafety. Swelling and retention studies showed that hydrogels were stable and could prolong the residence time of HA in the bladder. Histopathology and vascular permeability studies indicated that the hydrogels significantly attenuated bladder injury caused by CYP administration. Moreover, the hydrogels also showed excellent anti-inflammation and anti-oxidation properties. In conclusion, these data suggest that intravesical instillation of HA-SH/DMSO hydrogels reduces CYP-induced bladder toxicity and this work provides a new strategy for the prevention and early treatment of HC.

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“…1,1-Dimethylbiguanide hydrochloride, metformin (MET), is an anti-diabetic drug generally used for treatment of type II diabetes, which has been regarded to exert the neuroprotective through the anti-inflammatory (11) and antioxidant (12) actions. Recent studies have shown that MET has a protective effect against cyclophosphamideinduced cystitis in mice (13). Bladder dysfunction is very common in diabetes mellitus (14) and obesity (15).…”

Section: Introductionmentioning

confidence: 99%

Ovarektomize Dişi Sıçanlarda 1,1-Dimetilbiguanit Hidroklorid (Metformin)'in Detrüsör Kas Kontraktil Yanıtı Üzerine Etkileri

TURAN

Erdem

ERGENÇ

et al. 2022

Türk Diyab Obez / Turk J Diab Obes

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Aim: Menopause is defined as the depletion of the ovarian follicular reserve followed by the cessation of menstrual cycles. It has been reported that gonadal steroid hormones play an important role in bladder function in women. Changes in urine pattern including overactive bladder, stress incontinence and recurrent urinary tract infections occur as a result of menopause. 1,1-dimethylbiguanide hydrochloride, metformin, (MET) is an oral anti-diabetic drug used to reduce hepatic glucose production and peripheral insulin resistance. Recent studies have revealed that MET has a protective effects in diabetes induced bladder dysfunction. The aim of this study was to test the therapeutic potential of MET in detrusor contractile function of ovariectomized (OVX) female rats. Material and Methods: Bilateral ovariectomy was performed to eliminate endogenous gonadal steroids secretion. Four groups are designed with 8 animals in each group: Control, MET-administered control, OVX, and MET-administered OVX groups. MET (25 mg/ kg) was administered daily by oral gavage for 14 days. Contractile activity of isolated bladder muscle strips were evaluated in vitro organ bath. The contractile responses of detrusor strips were determined using different doses of carbachol (10-8-10-2M) and purinergic agonist ATP. The relaxation response of strips were determined by isoproterenol Results: The contractile responses of detrusor muscle strips to carbachol at doses 10-5-10-2 M were decreased in the OVX group compared to control and MET treated control groups. MET treatment partially reversed the reduction in OVX-induced contractile responses at 10-2 and 10 -3 M carbachol doses. There were no statistically significant difference in relaxation response between the experimental groups. Conclusion: Our findings suggest that treatment with MET could be the new potential therapeutic agent against bladder dyfunction in postmenopausal women. Further studies are needed for the therapeutic potential of MET in detrusor dysfunction induced by menopause.

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Double benefit of metformin treatment: improved bladder function in cyclophosphamide-induced cystitis and enhanced cytotoxicity in cancer cells

Cited by 11 publications

References 40 publications

Are C-reactive protein, neutrophil to lymphocyte, platelet to lymphocyte ratios, and mean platelet volume related to the severity of idiopathic carpal tunnel syndrome?

Are C-reactive protein, neutrophil to lymphocyte, platelet to lymphocyte ratios, and mean platelet volume related to the severity of idiopathic carpal tunnel syndrome?

Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury

Ovarektomize Dişi Sıçanlarda 1,1-Dimetilbiguanit Hidroklorid (Metformin)'in Detrüsör Kas Kontraktil Yanıtı Üzerine Etkileri

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