Abstract:13Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical 14 energy into heat, thereby increasing energy expenditure. Here, we identify Dot1L, the only 15 known H3K79 methyltransferase, as an interacting partner of Zc3h10 that transcriptionally 16 activates the UCP1 promoter and other BAT genes. Through a direct interaction, Dot1L is 17 recruited by Zc3h10 to the promoter regions of thermogenic genes to function as a coactivator 18 by methylating H3K79. We also show that Dot1L … Show more
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