DOT1-like histone lysine methyltransferase is critical for adult vessel maintenance and functions
HeeJi Lee,
Dong Wook Han,
Hyeonwoo La
et al.
Abstract:Objective: DOT1L is the only known histone H3K79 methyltransferase essential for the development of the embryonic cardiovascular system, including the heart, blood vessels, and lymphatic vessels, through transcriptional regulation. Our previous study demonstrated that Dot1l deletion results in aberrant lymphatic development and function. However, its precise function in the postnatal cardiovascular system remains unknown.Methods: Using conditional and inducible Dot1l knockout (KO) mice, along with a reporter s… Show more
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