Dosymmetric estimates of 99mTc (MAA) and 133Xe in newborn lungs using Cristy-Eckerman / Segars representations

Abstract

Using the Cristy-Eckerman (C-E) / Segars anatomical representations and the MIRD formalism, the Absorbed doses in lungs of newborn patients scanned with radiopharmaceuticals 133Xe (ventilation) and 99mTc (MAA) (perfusion) are estimated. These representations are phantoms used in Monte Carlo calculations to determine specific absorbed fractions, which, associated with the pharmaceutical residence time, determine the absorbed dose. Concerns about the dosimetric impact of using these ventilation / perfusion agents, as well as the use of different phantoms, were explored in newborn patients. When the lungs were scanned with 99mTc (MAA), the relative difference in total dose between the C-E / Segars anatomical representations was 1.0%. When the lungs were scanned with 133Xe, the relative difference in total dose between the anthropomorphic representations of C-E / Segars was 0.5%. Regardless of the radiopharmaceutical used for the pulmonary studies of a newborn patient, the substitution of the C-E representation for that of Segars does not reflect very significant changes in the calculation of the absorbed dose in the lungs, where the greatest dosimetric contribution is its self-dose, which is supplied mainly by the electrons produced during the 99mTc and 133Xe decay.

Radiopharmaceutical Renal Dosimetry Using Snyder / Cristy-Eckerman / Segars Anthropomorphic Representations

“…While the relative differences in the total doses in the uterine wall when using the Stabin and Segars phantoms are high, it depends on the representation of Stabin or Segars. It is also indicated that, regardless of the radiopharmaceutical used for pulmonary studies of a newborn patient, the substitution of the Cristy-Eckerman anthropomorphic representation for the Segars representation does not reflect very significant changes in the calculation of the absorbed dose in the lungs [20].…”