Dosing‐time, feeding, and sex‐dependent variations of everolimus pharmacokinetics in mice
Dilek Ozturk Civelek,
Narin Ozturk Seyhan,
Yasemin Kubra Akyel
et al.
Abstract:BackgroundEverolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly variable, it has a narrow therapeutic window and shows chronotoxicity with the best time at ZT13 and worst time at ZT1 (ZT; Zeitgeber time, time after light onset) in the preclinical setting.ObjectivesIn the present study, we aimed to investigate whether the pharmacokinetics of everolimus vary according to dosing time and whether sex and feeding status inter… Show more
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