Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts

Osterman-Golkar, Siv; Christakopoulos, Alexandros; Zorcec, V.; Svensson, Kettil

doi:10.1016/0009-2797(94)03348-x

Cited by 33 publications

(19 citation statements)

References 17 publications

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“…1). Similar nonlinearities have been observed in the dose-response curves for hemoglobin adduct formation with AN (Fennell et al, 1991) and other electrophiles (Walker et al, 1993;Osterman-Golkar et al, 1995). In the case of AN, a break in die dose-response curve occurred at one-tenth the dose reported here.…”

Section: Discussionsupporting

confidence: 63%

Dose Dependence of Covalent Binding of Acrylonitrile to Tissue Protein and Globin in Rats

Benz

Nerland

et al. 1997

Toxicol Sci

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This knot value is explained by the nearly complete depletion of liver glutathione and the resultant termination of AN detoxification. The toxicity of AN is known to increase sharply above this dose. The data suggest that a comparison of specific tissue proteins labeled by AN above and below this threshold dose may provide some insight into the mechanism of AN-induced toxicity.O 1997 Soctety of Toxicology.Acrylonitrile (AN) is a vinyl monomer used in the production of synthetic fibers, rubber, and plastics. The estimated production of AN in the United States in 1995 was 3.21 billion pounds, ranking it 40th among manufactured chemicals (Kirschner, 1996).

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Section: Discussionsupporting

confidence: 63%

Dose Dependence of Covalent Binding of Acrylonitrile to Tissue Protein and Globin in Rats

Benz

Nerland

et al. 1997

Toxicol Sci

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“…In animal experiments it has been demonstrated that both styrene and SO produce cysteine adducts in albumin (Alb) and hemoglobin (Hb) [17,22], N-terminal valine adducts in Hb [11], and carboxylic acid adducts in Hb [19]. However, applications of these assays to styrene-exposed workers in the reinforced-plastics industry have produced inconsistent results [2,3,19,20,25].…”

Section: Introductionmentioning

confidence: 99%

Albumin and hemoglobin adducts as biomarkers of exposure to styrene in fiberglass-reinforced-plastics workers

Fustinoni

Colosio

Colombi

et al. 1998

International Archives of Occupational and Environmental Health

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“…With other small olefins, just the opposite was found. In vivo burdens by metabolically formed epoxides or their hemoglobin adduct levels were higher in mice than that in rats (eg, butadiene: Csanády et al , 2011, Filser et al , 2007, van Sittert et al , 2000b; isoprene: Tareke et al , 1998; styrene: Filser et al , 2002, Osterman-Golkar et al , 1995; 4-vinylcyclohexene: Smith et al , 1990). These observations may at least partly result from the findings that the activity of hepatic microsomal epoxide hydrolase is lower in the mouse than in all other mammalian species investigated (Glatt and Oesch, 1987).…”

Section: Discussionmentioning

confidence: 98%

Ethylene Oxide in Blood of Ethylene-Exposed B6C3F1 Mice, Fischer 344 Rats, and Humans

Filser

Kessler

Artati

et al. 2013

Toxicological Sciences

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The gaseous olefin ethylene (ET) is metabolized in mammals to the carcinogenic epoxide ethylene oxide (EO). Although ET is the largest volume organic chemical worldwide, the EO burden in ET-exposed humans is still uncertain, and only limited data are available on the EO burden in ET-exposed rodents. Therefore, EO was quantified in blood of mice, rats, or 4 volunteers that were exposed once to constant atmospheric ET concentrations of between 1 and 10 000 ppm (rodents) or 5 and 50 ppm (humans). Both the compounds were determined by gas chromatography. At ET concentrations of between 1 and 10 000 ppm, areas under the concentration-time curves of EO in blood (µmol × h/l) ranged from 0.039 to 3.62 in mice and from 0.086 to 11.6 in rats. At ET concentrations ≤ 30 ppm, EO concentrations in blood were 8.7-fold higher in rats and 3.9-fold higher in mice than that in the volunteer with the highest EO burdens. Based on measured EO concentrations, levels of EO adducts to hemoglobin and lymphocyte DNA were calculated for diverse ET concentrations and compared with published adduct levels. For given ET exposure concentrations, there were good agreements between calculated and measured levels of adducts to hemoglobin in rats and humans and to DNA in rats and mice. Reported hemoglobin adduct levels in mice were higher than calculated ones. Furthermore, information is given on species-specific background adduct levels. In summary, the study provides most relevant data for an improved assessment of the human health risk from exposure to ET.

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Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts

Cited by 33 publications

References 17 publications

Dose Dependence of Covalent Binding of Acrylonitrile to Tissue Protein and Globin in Rats

Dose Dependence of Covalent Binding of Acrylonitrile to Tissue Protein and Globin in Rats

Albumin and hemoglobin adducts as biomarkers of exposure to styrene in fiberglass-reinforced-plastics workers

Ethylene Oxide in Blood of Ethylene-Exposed B6C3F1 Mice, Fischer 344 Rats, and Humans

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