Dosimetry of radiopharmaceuticals used in adult patients with suspected pulmonary embolism

Abstract

The absorbed dose of radiopharmaceuticals is estimated in adults with suspected pulmonary embolism explored by ventilation/perfusion studies. For pulmonary ventilation studies 81mKr, 133Xe, 99mTc (Technegas)-aerosol and 99mTc (DTPA)-aerosol are used. For perfusion agents, 99mTc(MAA), 99mTc (MSA) (macroaggregates and albumin microspheres) are used. For the dose calculation, the MIRD methodology and the anthropomorphic representation of the biokinetic organs of Cristy-Eckerman are used. In ventilation/perfusion studies, the lowest dose absorbed by the lungs with suspected embolism is due to 81mKr/ 99mTc (MSA), and the highest dose is due to 99mTc (Technegas)/99mTc (MAA) calculated for activities of 150 MBq for perfusion agents and 40 MBq for ventilation agents.

ESTIMASI DOSIS 99mTc-PERTEHNETAT DARI GENERATOR 99Mo / 99mTc NON-FISI PADA ANAK-ANAK USIA 1-15 TAHUN UNTUK PROSEDUR DIAGNOSTIK

“…erkembangan kedokteran nuklir menjadi salah satu ilmu yang dibutuhkan dalam mendiagnosis penyakit kanker. Kedokteran nuklir di Indonesia banyak mengembangkan radiofarmaka sebagai obat untuk terapi atau diagnosis suatu penyakit secara in vivo terutama kanker atau tumor [1,2]. Radioisotop yang paling banyak digunakan hingga saat ini yaitu 99m Tc.…”