2006
DOI: 10.1016/j.ijrobp.2005.07.970
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Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial

Abstract: Purpose-The α/β ratio for prostate cancer is postulated to be between 1 and 3, giving rise to the hypothesis that there may be a therapeutic advantage to hypofractionation. The dosimetry and acute toxicity are described in the first 100 men enrolled in a randomized trial.Patients and Methods-The trial compares 76 Gy in 38 fractions (Arm I) to 70.2 Gy in 26 fractions (Arm II) using intensity modulated radiotherapy. The planning target volume (PTV) margins in Arms I and II were 5 mm and 3 mm posteriorly and 8 mm… Show more

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Cited by 235 publications
(147 citation statements)
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“…27 Acute grade 3 and 4 toxicities were described in 0-8% of the patients. Pollack et al 28 evaluated 100 prostate cancer patients irradiated by IGRT with a total dose of 76 Gy, and only 2% of the patients suffered from severe toxicities. In our trial, severe GI and GU toxicities were reduced from 10% and 9%, respectively, to 5% by implementing IGRT without any grade 4 GU reactions.…”
Section: Discussionmentioning
confidence: 99%
“…27 Acute grade 3 and 4 toxicities were described in 0-8% of the patients. Pollack et al 28 evaluated 100 prostate cancer patients irradiated by IGRT with a total dose of 76 Gy, and only 2% of the patients suffered from severe toxicities. In our trial, severe GI and GU toxicities were reduced from 10% and 9%, respectively, to 5% by implementing IGRT without any grade 4 GU reactions.…”
Section: Discussionmentioning
confidence: 99%
“…Pollack [39] esetében az előfordulás ará-nya fordított volt, a normálfrakcionálású csoportban az esetek 8%-ánál, míg a hipofrakcionált csoportban 2%-ban jelentkeztek heveny tünetek. Súlyos toxicitás egyik vizsgálatban sem fordult elő.…”
Section: Akut éS Késői Gastrointestinalis Toxicitás (Normofrakcionáláunclassified
“…A normál-és hipofrakcionált csoportban Dearnaley [38] vizsgálatában 9, illetve 8%-ban, míg Pollack [39] elemzésében 56 és 48%-ban alakult ki mérsékelt urogenitalis mellék-hatás. Súlyos toxicitás nem alakult ki.…”
Section: Akut éS Késői Urogenitalis Toxicitás (Normofrakcionálás Vs unclassified
“…Target volumes for patients in the IMRT group have been previously described and included prostate only, prostate and seminal vesicles, or prostate and seminal vesicle and pelvic lymph nodes (19). For IMRT planning, patients were immobilized and their prostate localized in a similar fashion to those in the 3DCRT group.…”
Section: Radiation Therapymentioning
confidence: 99%