Dosimetry advantages of intraoperatively built custom-linked seeds compared with loose seeds in permanent prostate brachytherapy

Inada, Masahiro; Yokokawa, Miwa; Minami, Takafumi; Nakamatsu, Kiyoshi; Nishimura, Yasumasa

doi:10.5114/jcb.2017.70902

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…To date, many studies compared stranded seeds to loose seeds [ 9 , 13 , 14 , 19 , 20 , 21 ], but few studies have compared the implant quality of linked seeds with that of loose seeds for prostate brachytherapy [ 17 , 22 , 23 , 24 , 25 ]; however, until now, there have been no reports about the plan reproducibility of linked seeds. Generally, intraoperative dosimetry based on ultrasound would not predict biochemical outcome [ 26 ].…”

Section: Purposementioning

confidence: 99%

Plan reproducibility of intraoperatively custom-built linked seeds compared to loose seeds for prostate brachytherapy

Kaneda

Ohashi

Sakayori

et al. 2018

jcb

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PurposeFew studies have compared the implant quality of linked and loose seeds for prostate brachytherapy. This study aimed to evaluate and compare plan reproducibility of intraoperatively built custom linked seeds and loose seeds for prostate brachytherapy.Material and methodsBetween December 2010 and March 2014, 76 localized prostate cancer patients received Iodine-125 brachytherapy with external beam radiotherapy. Linked and loose seeds were implanted in 39 and 37 patients, respectively. The primary endpoint was the mean (± standard deviation) of the absolute change in the minimum dose received by 90% of the prostate volume between intraoperative and post-operative planning (ΔD90) to confirm plan reproducibility. Comparisons between the groups were evaluated using 2-sample t tests.ResultsThe ΔD90 values were 6.95 ± 11.6% and –0.41 ± 8.5% for the loose and linked seed groups, respectively (p < 0.01). The linked seed group showed decreased post-operative D90 (118.8% vs. 127.2%), V150 (51.7% vs. 66.7%), and RV100 (0.44 ml vs. 0.61 ml) compared to the loose seed group (p < 0.01), whereas lung migration tended to be reduced (0% vs. 8%).ConclusionsThe plan reproducibility of the linked seed group was better than that of the loose seed group. Moreover, the linked seed group showed less migration and lower rectal dose.

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Section: Purposementioning

confidence: 99%

Plan reproducibility of intraoperatively custom-built linked seeds compared to loose seeds for prostate brachytherapy

Kaneda

Ohashi

Sakayori

et al. 2018

jcb

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“…Several papers have reported no significant difference in PV 100 and PD 90 between the two groups [5,8,10]. Inada et al reported that PV 100 was significantly higher in the IBCL group than in the LS group, whereas other studies showed that PD 90 was significantly lower in the IBCL group than in the LS group [7,11,12,13]. In several studies, PV 150 and UD 30 were significantly lower and HI was significantly higher in the IBCL group than in the LS group, consistent with the results of the present study [7,11].…”

Section: Discussionmentioning

confidence: 99%

“…LDR brachytherapy was first adopted in 2003 in Japan, but stranded or linked seeds were not introduced until 2012, and only loose seeds (LS) had been used for LDR brachytherapy until then [ 6 ]. Several studies have reported the advantages and disadvantages of IBCL seeds compared with LS [ 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. IBCL seeds have the advantages of less migration, and stability due to intraoperative linking, indicating the benefits of loose and stranded seeds [ 14 ].…”

Section: Purposementioning

confidence: 99%

Comparison of post-implant dosimetrics between intraoperatively built custom-linked seeds and loose seeds by sector analysis at 24 hours and 1 month for localized prostate cancer

Okazaki¹,

Kuratsukuri²,

Nishikawa³

et al. 2020

jcb

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Purpose: To compare post-implant dosimetrics between intraoperatively built custom-linked (IBCL) seeds and loose seeds (LS) at 24 hours and 1 month by sector analysis, and to evaluate the effect of IBCL seeds with regard to change in dosimetric parameters, in patients with prostate cancer treated with brachytherapy. Material and methods: Consecutive patients treated for localized prostate cancer who received definitive brachytherapy between March 2013 and October 2017 were retrospectively analyzed. Prostate V 100 (PV 100), prostate D 90 (PD 90), prostate V 150 (PV 150), urethral D 30 (UD 30), urethral V 150 (UV 150), and rectal V 100 (RV 100) were assessed. Results: Thirty-two patients were treated with LS and 32 patients were treated with IBCL seeds. The median follow-up time was 49.9 months in the LS group and 27.1 months in the IBCL group. PV 150 , UV 150 , and UD 30 at 24 hours and UD 30 at 1 month showed significant difference (F-test), and standard deviation (SD) tended to be lower in the IBCL group. Analysis of change in the variables revealed significance for ΔPV 100 and ΔPD 90 (F-test, p = 0.014 and < 0.001, respectively), and ΔPV 150 and ΔUD 30 showed marginal significance (p = 0.084 and 0.097, respectively). PV 150 , UV 150 , and UD 30 at 24 hours and 1 month were significantly lower in the IBCL group, and there was no significant difference in PV 100 , PD 90 , and RV 100 compared with the LS group (t-test). The homogeneity index (HI) was significantly higher in the IBCL group (p < 0.001). Conclusions: In this retrospective single institutional study, there was a decrease in the SD of the dosimetric parameters in the IBCL group, and it was statistically significant in change in the variables between 24 hours and 1 month (F-test). The use of IBCL seeds significantly decreased PV 150 , UV 150 , and UD 30 , and significantly improved HI, without lowering PD 90 or PD 100 .

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“…LDR brachytherapy was performed with iodine-125 seeds as strands (S06 EZAG; 6711, Oncura) rather than loose seeds [ 18 ]. A transperineal procedure monitored by transrectal ultrasound was used, under continuous control of the z-axis by fluoroscopy until December 2005, exclusively ultrasound-based as real-time planning after December 2005.…”

Section: Methodsmentioning

confidence: 99%

Five-year effectiveness of low-dose-rate brachytherapy: comparisons with nomogram predictions in patients with non-metastatic prostate cancer presenting significant control of intra- and periprostatic disease

Zimmermann

Osieka

Bruns³

et al. 2018

jcb

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PurposeTo assess the effectiveness of low-dose-rate (LDR) brachytherapy in patients with localized prostate cancer and to compare the outcome with predictions from Kattan and Partin nomograms at 60 months after seed implantation.Material and methodsOne thousand, one hundred and eighty-seven patients with localized prostate cancer at low-, intermediate-, or high-risk of progression received LDR brachytherapy using iodine-125 seeds with curative intent, applied as monotherapy or in combination with external beam radiation therapy (EBRT), and/or androgen deprivation therapy (ADT). At 60 months after seed implantation, data of 1,064 patients (1,058 alive + 6 who died of prostate cancer) were analyzed for biochemical progression-free survival (bPFS) based on prostate-specific antigen (PSA) levels using the Phoenix definition. Five-year bPFS probabilities were determined for various risk group classifications (d’Amico, Mt. Sinai, MSKCC/Seattle, NCCN). Outcomes were also compared to patient-individualized nomogram predictions of 5-year bPFS (Kattan 2002) and probability of organ-confined disease (Kattan 2002, Partin 2007).ResultsOverall, 93.3% (993/1,064) of the patients were free of biochemical progression within 5 years, while the average 5-year bPFS probability according to the Kattan nomogram was significantly lower (85%, p < 0.001). Outcomes were significantly better than Kattan nomogram predictions in the subgroup of patients with monotherapy as well as in patients additionally treated with EBRT. Comparison of the overall outcome with nomogram predictions for organ-confined disease (Kattan nomogram: 50%; Partin nomogram: 65%) revealed a significant probability of LDR brachytherapy to destroy periprostatic tumor spread (p < 0.001) in all risk group constellations, even in high-risk patients.ConclusionsThe results indicate high effectiveness of LDR brachytherapy in all risk groups, significantly better than predicted with the Kattan nomogram in most subgroups. The significant superiority of LDR brachytherapy compared to nomogram predictions of organ-confined disease suggests that LDR brachytherapy effectively controls both intra- and periprostatic disease.

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Dosimetry advantages of intraoperatively built custom-linked seeds compared with loose seeds in permanent prostate brachytherapy

Cited by 6 publications

References 38 publications

Plan reproducibility of intraoperatively custom-built linked seeds compared to loose seeds for prostate brachytherapy

Plan reproducibility of intraoperatively custom-built linked seeds compared to loose seeds for prostate brachytherapy

Comparison of post-implant dosimetrics between intraoperatively built custom-linked seeds and loose seeds by sector analysis at 24 hours and 1 month for localized prostate cancer

Five-year effectiveness of low-dose-rate brachytherapy: comparisons with nomogram predictions in patients with non-metastatic prostate cancer presenting significant control of intra- and periprostatic disease

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