Dosimetric study of a brachytherapy treatment of esophagus with Brazilian 192Ir sources using an anthropomorphic phantom

Neves, Lucio Pereira; Santos, William S.; Gorski, Ronan; Perini, Ana Paula; Maia, Ana F.; Caldas, Linda V.E.; Orengo, Gilberto

doi:10.1016/j.radphyschem.2013.11.029

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…They have evaluated the dose distribution for a female adult mesh anthropomorphic phantom not only in the tumor but also in several healthy tissues. Table 3 presents a comparison between the dose (in percent) delivered to some sensitive organs due to the irradiation of 192 Ir source encapsulated in platinum [30] and our designed 252 Cf source. According to these data, it can be found that for our proposed shielded source, the esophagus which is located in the vicinity of the tumor receives about 30% of the total dose to the tumor, and the damage to the other investigated organs is predicted to be negligible.…”

Section: Discussionmentioning

confidence: 99%

“…Though the present study aims to investigate the efficiency of neutrons for delivering the desired dose to the target of interest, employing photon radioactive sources has previously been suggested in other works. For example, Neves et al [ 30 ] have accomplished a simulation-based study for brachytherapy of esophagus tumors using 192 Ir sources in three different configurations. They have evaluated the dose distribution for a female adult mesh anthropomorphic phantom not only in the tumor but also in several healthy tissues.…”

Section: Discussionmentioning

confidence: 99%

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A simulation study on using 252Cf for the treatment of esophagus tumor in human phantom

2020

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Due to the sensitivity of this tissue, and the potential for metastasis of its cancer as well, finding accurate methods to be employed for the treatment of esophagus tumors is of especial interest for the researchers. The present study deals with a Monte Carlo simulation of 252Cf neutron brachytherapy for treating these tumors using MCNPX (Version 2.6.0) code. The widely accepted AAPM TG-43 protocol has been used to benchmark the simulated source and to examine the accuracy of the modeling. The MIRD human phantom has been used for dose evaluation in the mentioned tumor and in the surrounding normal tissues as well. To decrease the dose delivered to the healthy tissue, using appropriate shields has been proposed. Through dosimetric calculations for several candidates, Pt-Ir 10% with a thickness of 1 cm has been selected as the optimized shield. The depth-dose results as well as the isodose curves corresponding to the presence of the shielded 252Cf neutron source in the center of the simulated tumor offer this source as an appropriate candidate to be used for the treatment of the esophagus tumors and sparing normal tissues. For a suggested clinical condition of positioning the source inside the esophagus, the damage to the first depth in spine can be avoided by managing the treatment time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A simulation study on using 252Cf for the treatment of esophagus tumor in human phantom

2020

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“…Good comparisons are presented for point mono-energetic source in water (Luxton & Jozsef, 1999;Almansa et al, 2006). While water phantoms are used for representing configurations similar to soft tissue, full anthropomorphic phantoms are also used to carry out detailed simulation for the dose (Neves et al, 2014) For MC simulations in brachytherapy (Lechtman et al, 2013;Mesbahi et al, 2013;Asadi et al, 2015) it has been shown that photon source energy and concentration are important factors that determine DEF while the size of GNPs is not so important (above the K-edge energy). Thus, in this work, a homogenous model with considerable savings on the computational effort, as well as a sensitivity capability is used to extract crucial information on the DEF from independent parameters.…”

Section: Introductionmentioning

confidence: 99%

Energy deposition and dose enhancement using Monte Carlo derivative sampling: applications in brachytherapy

Khan

Koreshi²,

Aziz³

et al. 2021

J. Natn. Sci. Foundation Sri Lanka

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Energy deposition and radiation dose distribution by the use of gold, a high-Z biocompatible element in water solution, is estimated as a function of source energy typical of brachytherapy sources (15 keV, 20 keV, 30 keV, 40 keV, 80 keV, 90 keV, 150 keV, 300 keV, 1 MeV), solution concentration (5-25 mg Au/g H 2 O), and solution placement (1-2 cm concentric shells). Monte Carlo (MC) simulations are carried out with the MCNP5 code, compared with other widely used MC codes such as PENELOPE and GEANT, to validate the dose estimates, which may vary considerably due to artifacts and data libraries, and extended to a sensitivity analysis using perturbation estimates. The energy deposition and radiation dose are estimated as a function of monoenergetic source radiation energy, and concentration of gold in solution. MC simulation is carried out in the coupled photon-electron radiation mode for x-rays emanating from a radiation source implanted in a water cell, for which results are valid for a cancer cell modelled by a spherical water phantom. For carrying out sensitivity studies, the Monte Carlo perturbation feature with material perturbations was used to sample derivatives in a single run which were used in a Taylor series to estimate both dose and Dose Enhancement Factor (DEF) from single MC runs. Close agreement was found between dose estimates from MCNP5, PENELOPE and GEANT, in spite of artifacts such as cut-offs in electron transport. It was also found that dose increases with energy of a source, and that dose enhancement, for a given concentration, decreases with source energy. The perturbation estimates result in enhanced computational efficiency.

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“…Entre elas, se encontra o trabalhode Moura et al (2014), pesquisadores do IPEN, que calcularam a dose absorvida em regiões próximas da superfície em meio de PMMA para fontes de Irídio-192 de alta taxa de dose. No mesmo ano,Neves et al (2014), estimados pelo TPS comercial Flexiplan 3D. Os resultados foram significativamente diferentes em algumas regiões.…”

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Caracterização dosimétrica de uma nova fonte oftálmica de Irídio-192 usando métodos experimentais e simulações de Monte Carlo

Angelocci¹

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Meu primeiro e mais importante agradecimento é para minha orientadora, Prof.ª Dr.ª Maria Elisa Chuery Martins Rostelato, que me aceitou em seu grupo e se dedicou para garantir que cada um dos envolvidos no projeto tivesse as condições necessárias para desenvolvê-lo.Também gostaria de agradecer a outros professores e profissionais do CETER (Centro de Tecnologia das Radiações) que disponibilizaram tempo, recursos e conselhos para que este trabalho fosse realizado:

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Dosimetric study of a brachytherapy treatment of esophagus with Brazilian 192Ir sources using an anthropomorphic phantom

Cited by 5 publications

References 6 publications

A simulation study on using 252Cf for the treatment of esophagus tumor in human phantom

A simulation study on using 252Cf for the treatment of esophagus tumor in human phantom

Energy deposition and dose enhancement using Monte Carlo derivative sampling: applications in brachytherapy

Caracterização dosimétrica de uma nova fonte oftálmica de Irídio-192 usando métodos experimentais e simulações de Monte Carlo

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