Dosimetric intercomparison for multicenter clinical trials using a patient‐based anatomic pelvic phantom

Abstract

A phantom based on realistic anatomy and heterogeneity can be used to comprehensively assess the influence of multiple aspects of the radiotherapy treatment process on dose delivery. The ability to verify dose delivery for two trials with a single phantom was advantageous.

Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial

“…Consistency in EBRT dose delivery was assessed via dosimetric audit of centres [3][4][5][6][7] and adherence to trial planning protocol via expert review of each treatment plan [8].…”

Design, manufacture, and evaluation of an anthropomorphic pelvic phantom purpose-built for radiotherapy dosimetric intercomparison

“…Identical planning and treatment protocols were subsequently used in the multicenter intercomparison for which the phantom was built. 25 The methodology involved loading the phantom with retired TLD crystals (to act as visual cues for identifying the point doses on the treatment plan) and the "dummy" chamber in the chamber cavity. The phantom was positioned in the radiotherapy CT scanner (GE Lightspeed RT wide-bore Scanner utilizing Advantage-Sim software) and helical scans of 2.5 cm slice intervals were taken with a tube voltage of 140 kVp and current of 250 mA.…”

“…During 2004-2008, the phantom was utilized in a multicenter Level III dosimetric intercomparison at 36 radiotherapy centers across Australia and New Zealand. This study 7,25 required extensive manual handling and transport of the phantom and associated equipment by air and motor vehicle (approximately sixteen domestic and four international flights and approximately 3000 km of motor vehicle travel). The phantom was transported in a standard soft-sided suitcase with additional foam padding, and was handled as standard luggage by all carriers.…”

Anthropomorphic Phantoms for Radiation Oncology Medical Physics

“…The RPC is not the only QA service to use anthropomorphic body-parts. Harrison et al [21] described the use of a pelvic phantom for an Australian multicenter radiotherapy dosimetry comparison [22]. The Australian pelvic phantom was a solid phantom that had structures representing bone, organ and backfill and it could accommodate the placement of TLD and an ion chamber at various locations.…”