Dosimetric implications of kidney anatomical volume changes in 177Lu-DOTATATE therapy
Jehangir Khan,
Tobias Rydèn,
Martijn Van Essen
et al.
Abstract:Introduction
This study aims to evaluate the use of CT-based whole kidney parenchyma (WKP) segmentation in 177Lu-DOTATATE dosimetry. Specifically, it investigates whether WKP volumes change during treatment and evaluates the accuracy of applying a single delineated WKP volume for dosimetry. Furthermore, it aims to determine the cause of WKP volume changes—whether caused by radiation or amino acid infusion—by comparing them with spleen volume changes as a marker for radiation-induced alterations… Show more
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