Dosimetric implications of changes in patient repositioning and organ motion in conformal radiotherapy for prostate cancer

Physical and clinical implications of radiotherapy treatment of prostate cancer using a full bladder protocol

“…With regard to the urinary bladder filling state, it is, in general, suggested to maintain a constant bladder volume [4], i.e., either empty or filled. In clinical experience, it is widely accepted that treatment with an empty bladder allows a more reproducible anatomy to be achieved [18,38]. Dawson et al [7] reported that even in this case the bladder volume is not constant during the treatment; the same observation was reported by Pinkawa et al [25].…”

Postoperative Radiotherapy for Prostate Cancer

“…An EB was recommended in the past by many authors to reduce the prostate mobility [11,13,26,30]. These arguments were transferred to post-radical prostatectomy RT [22,28].…”

“…Several studies have demonstrated an influence of bladder and rectum volumes on the prostate movement in primary RT [13,25,29,30]. Only one recent study dealt with organ motion during post-radical prostatectomy RT [4].…”

Radiobiological Modelling in Radiation Oncology

“…Improved quantification of IGRT treatment of the prostate I nter-fraction organ motion is a well known problem in RT (van Herk et al 1995;Roeske et al 1995;Rudat et al 1996;Melian et al 1997;Tinger et al 1998;Antolak et al 1998;Stroom et al 1999;Zelefsky et al 1999;Fraser et al 2010;Barrett et al 2008) as anatomical changes in the path of treatment beams have been shown to alter the dose distribution throughout RT treatment (Happersett et al 2003;Lujan et al 2003;Miralbell et al 2003;Schaly et al 2004;Stroom et al 2000). Traditionally, the PTV is used to manage this problem.…”