Dosimetric evaluation of the skin-sparing effects of 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy for left breast cancer

Abstract

The purpose of this study was to evaluate the skin-sparing effects of 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in patients with early left-sided breast cancer. Twenty left breast cancer patients treated with whole breast radiotherapy following breast-conserving surgery were enrolled in this study, and the 3D-CRT and IMRT plans were generated for each patient. To evaluate the dose delivered to the skin, 2 mm thickness skin (2-mm skin) and 3 mm thickness skin (3-mm skin) were contoured and a dosimetric comparison between the 2 plans was performed. The target volume coverage was better in IMRT than in 3D-CRT. The mean dose was 50.8 Gy for 3D-CRT and 51.1 Gy for IMRT. V40Gy was 99.4% for 3D-CRT and 99.9% for IMRT. In the case of skin, the mean dose was higher in 3D-CRT than in IMRT (mean dose of 2-mm skin: 32.8 Gy and 24.2 Gy; mean dose of 3-mm skin: 37.2 Gy and 27.8 Gy, for 3D-CRT and IMRT, respectively). These results indicated that the skin-sparing effect is more prominent in IMRT compared to 3D-CRT without compromising the target volume coverage.

WITHDRAWN: Radiation-Induced Acute Injury of Intensity-Modulated Radiotherapy vs. Three-Dimensional Conformal Radiotherapy in Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Prospective Cohort Study

“…Several studies have revealed that IMRT could provide reduced irradiation to the normal tissue without compromising target volume coverage, which is an advantage of the technique. 28 Data directly comparing acute side effects of NPC patients treated with IMRT and 3D-CRT are lacking in the literature as well, but lower rates of wound healing complications with IMRT were referred to more recent studies. 18 In our study, reduced hyperpigmentation and bone marrow toxicity appeared more remarkable in light of the treatment performed in the IMRT group than those of the 3D-CRT group and this difference remained robust in a univariate and multivariate analysis.…”

WITHDRAWN: Radiation-induced acute injury of intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy in induction chemotherapy followed by concurrent chemoradiotherapy for nasopharyngeal carcinoma: a prospective cohort study

“…Several studies have revealed that IMRT could provide reduced irradiation to the normal tissue without compromising target volume coverage, which is an advantage of the technique [28]. Data directly comparing acute side effects of NPC patients treated with IMRT and 3D-CRT are lacking in the literature as well, but lower rates of wound healing complications with IMRT were referred to more recent studies [18].…”

Robustness of VMAT and 3DCRT plans toward setup errors in radiation therapy of locally advanced left-sided breast cancer with DIBH

“…The flash intends to ensure good breast coverage even when intra-or interfractional movement should occur, or in the case of breast swelling or deformation during the RT course. It has been shown that intensity modulated radiation therapy (IMRT) has a better skin-sparing effect than traditional 3DCRT as well as improving the target homogeneity [16,17]. Treatment plans using the VMAT technique will typically try to achieve good target coverage of planning target volume (PTV), but intra-and interfraction setup variation as well as changes in breast contour might jeopardize the coverage.…”