Dosimetric evaluation of a novel polymer gel dosimeter for proton therapy

Zeidan, O.; Sriprisan, Sirikul; Lopatiuk-Tirpak, O.; Kupelian, Patrick A.; Meeks, Sanford L.; Hsi, W. C.; Li, Z.; Palta, Jatinder; Maryanski, M

doi:10.1118/1.3388869

Cited by 59 publications

(45 citation statements)

References 19 publications

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“…However, dosimetric gels can be difficult to work with, requiring careful preparation and handling procedures. They also require an extra readout step (Guo et al , 2006; Zeidan et al , 2010), which necessitates a dedicated read-out device and can be relatively time consuming depending on the size of the gel and the desired resolution.…”

Section: Introductionmentioning

confidence: 99%

3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles—a simulation study

2014

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An accurate and high-resolution quality assurance (QA) method for proton radiotherapy beams is necessary to ensure correct dose delivery to the target. Detectors based on a large volume of liquid scintillator have shown great promise in providing fast and high-resolution measurements of proton treatment fields. However, previous work with these detectors has been limited to two-dimensional measurements, and the quantitative measurement of dose distributions was lacking. The purpose of the current study is to assess the feasibility of reconstructing three-dimensional (3D) scintillation light distributions of spot scanning proton beams using a scintillation system. The proposed system consists of a tank of liquid scintillator imaged by charge-coupled device cameras at three orthogonal viewing angles. Because of the limited number of viewing angles, we developed a profile-based technique to obtain an initial estimate that can improve the quality of the 3D reconstruction. We found that our proposed scintillator system and profile-based technique can reconstruct a single energy proton beam in 3D with a gamma passing rate (3%/3 mm local) of 100.0%. For asingle energy layer of an intensity modulated proton therapy prostate treatment plan, the proposed method can reconstruct the 3D light distribution with a gamma pass rate (3%/3 mm local) of 99.7%. In addition, we also found that the proposed method is effective in detecting errors in the treatment plan, indicating that it can be a very useful tool for 3D proton beam QA.

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Section: Introductionmentioning

confidence: 99%

3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles—a simulation study

2014

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“…A BANG3-Pro2 polymer gel was evaluated for dosimetry in proton beams. 17 Quantitative dose distribution comparisons to treatment planning system calculations show that >97% of the gel dose maps pass the 3%/3mm gamma criterion. However, Gel dosimetry requires a CT scanner for the dose readout process and also requires a dark environment in the scanning area to minimize effects of stray light which can contribute to the photodetector signal.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the dosimetric properties of a synthetic single crystal diamond detector in high energy clinical proton beams

Mandapaka¹,

Ghebremedhin²,

Patyal³

et al. 2013

Medical Physics

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Purpose: To investigate the dosimetric properties of a synthetic single crystal diamond Schottky diode for accurate relative dose measurements in large and small field high-energy clinical proton beams. Methods:The dosimetric properties of a synthetic single crystal diamond detector were assessed by comparison with a reference Markus parallel plate ionization chamber, an Exradin A16 microionization chamber, and Exradin T1a ion chamber. The diamond detector was operated at zero bias voltage at all times. Comparative dose distribution measurements were performed by means of Fractional depth dose curves and lateral beam profiles in clinical proton beams of energies 155 and 250 MeV for a 14 cm square cerrobend aperture and 126 MeV for 3, 2, and 1 cm diameter circular brass collimators. ICRU Report No. 78 recommended beam parameters were used to compare fractional depth dose curves and beam profiles obtained using the diamond detector and the reference ionization chamber. Warm-up/stability of the detector response and linearity with dose were evaluated in a 250 MeV proton beam and dose rate dependence was evaluated in a 126 MeV proton beam. Stem effect and the azimuthal angle dependence of the diode response were also evaluated. Results: A maximum deviation in diamond detector signal from the average reading of less than 0.5% was found during the warm-up irradiation procedure. The detector response showed a good linear behavior as a function of dose with observed deviations below 0.5% over a dose range from 50 to 500 cGy. The detector response was dose rate independent, with deviations below 0.5% in the investigated dose rates ranging from 85 to 300 cGy/min. Stem effect and azimuthal angle dependence of the diode signal were within 0.5%. Fractional depth dose curves and lateral beam profiles obtained with the diamond detector were in good agreement with those measured using reference dosimeters. Conclusions:The observed dosimetric properties of the synthetic single crystal diamond detector indicate that its behavior is proton energy independent and dose rate independent in the investigated energy and dose rate range and it is suitable for accurate relative dosimetric measurements in large as well as in small field high energy clinical proton beams.

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“…We used a modified version of the BANG3 polymer gel dosimeter, BANG3-Pro-2 from MGS Research (Guilford, CT), which is currently only a commercial vendor of the RPGDs for radiation dosimetry [12]. The RPGD was contained in a 15-cm diameter and 15-cm long cylinder made of thin plastic walls (see Fig.…”

Section: Methodsmentioning

confidence: 99%

Dosimetric verification for intensity-modulated arc therapy plans by use of 2D diode array, radiochromic film and radiosensitive polymer gel

Hayashi

Malmin

Watanabe³

2014

Journal of Radiation Research

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Several tools are used for the dosimetric verification of intensity-modulated arc therapy (IMAT) treatment delivery. However, limited information is available for composite on-line evaluation of these tools. The purpose of this study was to evaluate the dosimetric verification of IMAT treatment plans using a 2D diode array detector (2D array), radiochromic film (RCF) and radiosensitive polymer gel dosimeter (RPGD). The specific verification plans were created for IMAT for two prostate cancer patients by use of the clinical treatment plans. Accordingly, the IMAT deliveries were performed with the 2D array on a gantry-mounting device, RCF in a cylindrical acrylic phantom, and the RPGD in two cylindrical phantoms. After the irradiation, the planar dose distributions from the 2D array and the RCFs, and the 3D dose distributions from the RPGD measurements were compared with the calculated dose distributions using the gamma analysis method (3% dose difference and 3-mm distance-to-agreement criterion), dose-dependent dose difference diagrams, dose difference histograms, and isodose distributions. The gamma passing rates of 2D array, RCFs and RPGD for one patient were 99.5%, 96.5% and 93.7%, respectively; the corresponding values for the second patient were 97.5%, 92.6% and 92.9%. Mean percentage differences between the RPGD measured and calculated doses in 3D volumes containing PTVs were –0.29 ± 7.1% and 0.97 ± 7.6% for the two patients, respectively. In conclusion, IMAT prostate plans can be delivered with high accuracy, although the 3D measurements indicated less satisfactory agreement with the treatment plans, mainly due to the dosimetric inaccuracy in low-dose regions of the RPGD measurements.

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Dosimetric evaluation of a novel polymer gel dosimeter for proton therapy

Cited by 59 publications

References 19 publications

3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles—a simulation study

3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles—a simulation study

Evaluation of the dosimetric properties of a synthetic single crystal diamond detector in high energy clinical proton beams

Dosimetric verification for intensity-modulated arc therapy plans by use of 2D diode array, radiochromic film and radiosensitive polymer gel

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