Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy

Altınok, Pelin; Tekçe, Ertuğrul; Karakose, Fatih; Berk, Kemal; Kalafat, U.; Kızıltan, Huriye Şenay; Akgün, Züleyha; Mayadağlı, Alpaslan

doi:10.4103/jcrt.jcrt_548_18

Cited by 3 publications

(3 citation statements)

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“…Allaveisi et al [14] compared the FIF and 4FB methods in terms of the mean dose for OARs (the heart, liver, left lung, and right lung) in patients with esophageal cancer and found that FIF was not superior to 4FB in terms of mean dose reduction, which agreed with our observation. In addition, Altinok et al [35] compared the FIF and 3D CRT techniques in terms of the mean dose delivered to OARs (the right kidney, left kidney, liver, and spinal cord) in patients with gastric cancer and reported a lower mean dose exposition to OARs in the former approach compared to the latter, which was also consistent the results of the present study.…”

Section: Discussionsupporting

confidence: 91%

Assessment of Field-in-Field, 3-Field, and 4-Field Treatment Planning Methods for Radiotherapy of Gastro-Esophageal Junction Cancer

et al. 2022

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Background: Gastro-esophageal (GE) junction cancer is the fastest-growing tumor, particularly in the United States (US).Objective: This study aimed to compare dosimetric and radiobiological factors among field-in-field (FIF), three-field (3F), and four-field box (4FB) radiotherapy planning techniques for gastro-esophageal junction cancer. Material and Methods:In this experimental study, thirty patients with GE junction cancer were evaluated, and three planning techniques (field-in-field (FIF), three-field (3F), and four-field box (4FB)) were performed for each patient for a 6-MV photon beam. Dose distribution in the target volume, the monitor units (MUs) required, and the dose delivered to organs at risk (OARs) were compared for these techniques using the paired-sample t-test.Results: A significant difference was measured between the FIF and 3F techniques with respect to conformity index (CI), dose homogeneity index (HI), and tumor control probability (TCP) for the target organ, as well as the D mean for the heart, kidneys, and liver. For the spinal cord, the FIF technique showed a slight reduction in the maximum dose compared to the other two techniques. In addition, the V 20 Gy of the lungs and the normal tissue complication probability (NTCP) of all OARs were reduced with FIF method. Conclusion:The FIF technique showed better performance for treating patients with gastro-esophageal junction tumors, in terms of dose homogeneity in the target, conformity of the radiation field with the target volume, TCP, less dose to healthy organs, and fewer MU.

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Section: Discussionsupporting

confidence: 91%

Assessment of Field-in-Field, 3-Field, and 4-Field Treatment Planning Methods for Radiotherapy of Gastro-Esophageal Junction Cancer

et al. 2022

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“…Among the different methods for intensity-modulated radiotherapy (IMRT), helical tomotherapy stands out for its highly conformal and homogeneous dose distribution (24,25). Therefore, helical tomotherapy often results in better conformity and homogeneity index scores than other IMRT techniques, such as step-and-shoot IMRT and volumemodulated arc therapy (VMAT) IMRT (33,34).…”

Section: Discussionmentioning

confidence: 99%

“…A relatively new development in percutaneous photon radiation therapy is helical intensity modulated radiotherapy (IMRT), called tomotherapy. In most cases, this technique achieves the steepest dose gradient (conformity index close to 1), lowest values of dose maxima, and best dose homogeneity within the target volume compared to other IMRT and rotational techniques (24,25).…”

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confidence: 93%

Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

Zwicker¹,

Hoefel²,

Kirchner³

et al. 2021

Anticancer Res

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Background/Aim: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined. Patients and Methods: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/ 8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/ 28 fractions+16 Gy/ 8 fractions). Equivalent doses (EQD 2 ) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values. Results: The mean EQD 2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD 2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. Conclusion: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques.Globally, breast cancer is the most common form of cancer in women (1). Surgery and adjuvant radiation therapy are the central pillars of curative therapy when treating localised breast cancer. Screening programs enable tumours to be discovered earlier, meaning that breast-conserving surgery alongside adjuvant radiotherapy achieves high cure rates. Additional radiotherapy significantly increases local control and prolongs overall survival (2, 3). As part of adjuvant radiation therapy, a radiation boost to the tumour bed results in significantly improved local control rates in the case of risk factor constellations, such as T2 tumours, positive lymph nodes, premenopausal patients, poorly differentiated G3 tumours, human-epidermal-growth-factor-receptor2 (HER2/ neu) positivity, and narrow resection margins (4, 5). The radiation boost can be applied in several ways: teletherapy using photons or electrons, intra-operative radiotherapy, or interstitial brachytherapy (6-9). Thus far, the radiation boost is generally delivered sequentially, i.e., once whole breast radiation therapy is complete. Simultaneous integrated boost (SIB) radiation therapy is a recent approach to delivering radiation boosts (6). SIB can be administered using different percutaneous photon therapy radiation techniques, including 3D conformal radiation therapy (3D-CRT) and intensitymodulated radiation therapy (IMRT).Step-and-shoot IMRT and rotational IMRT, also known as volumetric arc therapy (VMAT), are commonly reported in the literature (6, 10, 11). The advantages of SIB in comparison to sequential boost (SB) include the reduced total ...

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Study on the feasibility of quality improvement for automatic plans based on rapid plan model

Ma,

Yu,

et al. 2022

J Can Res Ther

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Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy

Cited by 3 publications

References 1 publication

Assessment of Field-in-Field, 3-Field, and 4-Field Treatment Planning Methods for Radiotherapy of Gastro-Esophageal Junction Cancer

Assessment of Field-in-Field, 3-Field, and 4-Field Treatment Planning Methods for Radiotherapy of Gastro-Esophageal Junction Cancer

Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

Study on the feasibility of quality improvement for automatic plans based on rapid plan model

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