Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy

Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer

“…4 Nevertheless, in most women, the heart still receives doses of 1 to 5 Gy. [5][6][7][8][9][10][11] Several studies have suggested that exposures at this level can cause is che mic heart disease, [12][13][14] but the magnitude of the risk after any given dose to the heart is uncertain, as are the time to the development of any radiation-related disease and the influence of other cardiac risk factors. We therefore conducted a study relating the risk of is chemic heart disease after radiotherapy to each woman's radiation dose to the heart and to any cardiac risk factors she had at the time of radiotherapy.…”

Efficacy of the Dynamic Jaw Mode in Helical Tomotherapy With Static Ports for Breast Cancer

“…Second, the candidates of this study were limited to patients with left-sided breast cancer similar to previous studies, because the heart was considered to be one of the most important OARs. 7,8 The dose of the liver might possibly be affected if the patients with right-sided breast cancer are evaluated. Third, comparison with conventional radiotherapy and IMRT using a linear accelerator was not carried out in this study.…”

“…[3][4][5] Tomotherapy is considered one of the suitable IMRT modalities for breast cancer. [6][7][8][9] However, helical tomotherapy plans produce larger low-dose volumes of the other OARs compared with plans with conventional techniques. 6,7 The static tomotherapy delivery mode (TomoDirect) can reduce doses to the contralateral breast and low-dose irradiated volume in the lung for patients with breast cancer.…”

“…6,7 The static tomotherapy delivery mode (TomoDirect) can reduce doses to the contralateral breast and low-dose irradiated volume in the lung for patients with breast cancer. [8][9][10] With the conventional fixed jaw mode of tomotherapy, the craniocaudal dose penumbra is a concern; this problem can be partly solved by using a narrower jaw width, but treatment time becomes much longer. More suitable compromise between craniocaudal dose spread and treatment time may be the use of the recently developed dynamic jaw technology with dynamic adaptation of field width at cranial and caudal edges of a target.…”

Treatment with intensity-modulated radiation therapy (IMRT) for breast cancer

“…5,6 The same was noted with regard to other structures such as the heart and lungs (ipsilateral and contralateral), which can be associated with a reduced risk for chronic lung and heart disease (B). [7][8][9][10][11][12][13][14] This benefit was also demonstrated in patients undergoing mastectomy and adjuvant radiation therapy for plastron (B). 7 Recommendation Intensity-modulated radiation therapy (IMRT) is a modality that provides better dose distribution in breast irradiation.…”