Dosimetric comparison of intensity modulated radiotherapy and intensity modulated proton therapy in the treatment of recurrent nasopharyngeal carcinoma

Hung, H.M.; Chan, Oliver Cheuk Ming; Mak, Chi Hang Christopher; Hung, Wai Man; Ng, Wai Tong; Lee, Michael Chi Hang

doi:10.1016/j.meddos.2021.07.002

Cited by 6 publications

(15 citation statements)

References 31 publications

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“…Among these included studies, nine were conducted in the United States [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] and 6 in China [20] , [21] , [22] , [23] , [24] , [25] . The remaining studies were conducted in Germany (n = 2) [26] , [27] , Italy (n = 2) [28] , [29] , Japan (n = 2) [30] , [31] , South Korea (n = 2) [32] , [33] , Taiwan (n = 1) [34] , Czech Republic (n = 1) [35] and Hong Kong (n = 1) [36] .…”

Section: Resultsmentioning

confidence: 99%

“…Seven papers had a patient size of 50 or more [13] , [20] , [21] , [22] , [26] , [32] , [34] , and only one of them had a sample size of more than 100 [21] ( Table 1 ). By definition of NPC in this systematic review, seventeen studies included patients with primary [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [22] , [26] , [27] , [28] , [31] , [33] , [34] , [35] and 8 included recurrent NPC [20] , [21] , [23] , [24] , [25] , [29] , [32] , [36] . The remaining study included both [30] .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, thirteen studies used PBT as the intervention [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [29] , [31] , [34] , [35] , [36] , while 6 studies treated patients with CIBT [20] , [21] , [23] , [24] , [25] , [30] . The other 6 studies used a mixed beam approach, combining photon plus PBT or CIBT [11] , [22] , [26] , [27] , [28] , [33] .…”

Section: Resultsmentioning

confidence: 99%

“…Safety outcomes: a. Toxicity b. Gastrostomy tube dependency Hung, H.M. et al (2021; Hong Kong) [36] 20 T3: 18 T4: 2 N0: 14 N1: 6 N/A N/A Recurrent NPC N/A N/A N/A 60 Gy IMPT IMRT 1. Dose-related outcomes: a.…”

Section: Methodsmentioning

confidence: 99%

“…The 26 studies included a total of 1502 NPC patients, with sample sizes varying from 10 to 358. Seven papers had a patient size of 50 or more [13,[20][21][22]26,32,34], and only one of them had a sample size of [20,21,[23][24][25]29,32,36]. The remaining study included both [30].…”

Section: Participantsmentioning

confidence: 99%

See 4 more Smart Citations

Particle beam therapy for nasopharyngeal cancer: A systematic review and meta-analysis

Ng¹,

But²,

Wong³

et al. 2022

Clinical and Translational Radiation Oncology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

See 3 more Smart Citations

Particle beam therapy for nasopharyngeal cancer: A systematic review and meta-analysis

Ng¹,

But²,

Wong³

et al. 2022

Clinical and Translational Radiation Oncology

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Is noncoplanar plan more robust to inter‐fractional variations than coplanar plan in treating bilateral HN tumors with pencil‐beam scanning proton beams?

Yi,

Jatczak,

Deng

et al. 2023

J Applied Clin Med Phys

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PurposeNoncoplanar plans (NCPs) are commonly used for proton treatment of bilateral head and neck (HN) malignancies. NCP requires additional verification setup imaging between beams to correct residual errors of robotic couch motion, which increases imaging dose and total treatment time. This study compared the quality and robustness of NCPs with those of coplanar plans (CPs).Methods and MaterialsUnder an IRB‐approved study, CPs were created retrospectively for 10 bilateral HN patients previously treated with NCPs maintaining identical beam geometry of the original plan but excluding couch rotations. Plan robustness to the inter‐fractional variation (IV) of both plans was evaluated through the Dose Volume Histograms (DVH) of weekly quality assurance CT (QACT) sets (39 total). In addition, delivery efficiency for both plans was compared using total treatment time (TTT) and beam‐on time (BOT).ResultsNo significant differences in plan quality were observed in terms of clinical target volume (CTV) coverage (D95) or organ‐at‐risk (OAR) doses (p > 0.4 for all CTVs and OARs). No significant advantage of NCPs in the robustness to IV was found over CP, either. Changes in D95 of QA plans showed a linear correlation (slope = 1.006, R2 > 0.99) between NCP and CP for three CTV data points (CTV1, CTV2, and CTV3) in each QA plan (117 data points for 39 QA plans). NCPs showed significantly higher beam delivery time than CPs for TTT (539 ± 50 vs. 897 ± 142 s; p < 0.001); however, no significant differences were observed for BOT.ConclusionNCPs are not more robust to IV than CPs when treating bilateral HN tumors with pencil‐beam scanning proton beams. CPs showed plan quality and robustness similar to NCPs while reduced treatment time (∼6 min). This suggests that CPs may be a more efficient planning technique for bilateral HN cancer proton therapy.

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Limited applicability and implementation of the international oncology treatments guidelines in low- and middle-income countries, an example from the Mediterranean area borders

Belkacémi

Biston

Benchekroun

et al. 2023

Cancer/Radiothérapie

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Dosimetric comparison of intensity modulated radiotherapy and intensity modulated proton therapy in the treatment of recurrent nasopharyngeal carcinoma

Cited by 6 publications

References 31 publications

Particle beam therapy for nasopharyngeal cancer: A systematic review and meta-analysis

Particle beam therapy for nasopharyngeal cancer: A systematic review and meta-analysis

Is noncoplanar plan more robust to inter‐fractional variations than coplanar plan in treating bilateral HN tumors with pencil‐beam scanning proton beams?

Limited applicability and implementation of the international oncology treatments guidelines in low- and middle-income countries, an example from the Mediterranean area borders

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