Dosimetric comparison of different treatment planning techniques with International Commission on Radiation Units and Measurements Report-83 recommendations in adjuvant pelvic radiotherapy of gynecological malignancies

Duman, Evrim; Inal, Aysun; Sengul, Aycan; Koca, Timur; Çeçen, Yiğit; Yavuz, Mustafa

doi:10.4103/0973-1482.179189

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…Like many studies, 4 , 24 , 25 , 26 , 27 , 28 our study discovered that IMRT for CCRT of cervical cancer did not worsen the survival outcomes compared to 3DCRT. Our study showed that the 2‐year, 3‐year, and 5‐year OS rates in IMRT and 3DCRT groups were 76.8%, 75.0%, and 58.3% and 81.3%, 73.7%, and 66.1%, respectively.…”

Section: Discussionsupporting

confidence: 74%

Comparison of survival, acute toxicities, and dose–volume parameters between intensity‐modulated radiotherapy with or without internal target volume delineation method and three‐dimensional conformal radiotherapy in cervical cancer patients: A retrospective and propensity score‐matched analysis

et al. 2021

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Section: Discussionsupporting

confidence: 74%

Comparison of survival, acute toxicities, and dose–volume parameters between intensity‐modulated radiotherapy with or without internal target volume delineation method and three‐dimensional conformal radiotherapy in cervical cancer patients: A retrospective and propensity score‐matched analysis

et al. 2021

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“…Third, none of the included studies described pelvic radiotherapy techniques or the dose limit of intestinal tissues. With the progress of radiotherapy techniques, different radiotherapy techniques employ different doses for intestinal tissues in pelvic radiotherapy[ 45 – 47 ]. However, the relationship between radiotherapy dose and changes in bacterial flora could not be clarified from these studies.…”

Section: Limitationsmentioning

confidence: 99%

The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review

Wang

Zhang

et al. 2021

Radiat Oncol

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Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radiation field is inevitably damaged, a phenomenon clinically referred to as radiation enteritis, and diarrhoea is the most common clinical symptom of radiation enteritis. Therefore, it is necessary to study the mechanism of radiation-induced diarrhoea. It has been found that the gut microbiome plays an important role in the development of diarrhoea in response to pelvic radiotherapy, and the species and distribution of intestinal microbiota are significantly altered in patients after pelvic radiotherapy. In this study, we searched for articles indexed in the Cochrane Library, Web of Science, EMBASE and PubMed databases in English and CNKI, Wanfang data and SINOMED in Chinese from their inception dates through 13 March 2020 to collect studies on the gut microbiome in pelvic radiotherapy patients. Eventually, we included eight studies: one study report on prostatic carcinoma, five studies on gynaecological carcinoma and two papers on pelvic carcinomas. All studies were designed as self-controlled studies, except for one that compared toxicity to nontoxicity. The results from all the studies showed that the diversity of intestinal flora decreased during and after pelvic radiotherapy, and the diversity of intestinal flora decreased significantly in patients with diarrhoea after radiotherapy. Five studies observed that the community composition of the gut microbiota changed at the phylum, order or genus level before, during, and after pelvic radiotherapy at different time points. In addition, the composition of the gut microbiota before radiotherapy was different between patients with postradiotherapy diarrhoea and those without diarrhoea in five studies. However, relevant studies have not reached consistent results regarding the changes in microbiota composition. Changes in the intestinal flora induced by pelvic radiotherapy and their relationship between changes in intestinal flora and the occurrence of radiation-induced diarrhoea (RID) are discussed in this study, providing a theoretical basis for the causes of RID after pelvic radiotherapy.

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“…With the four-field box technique, the bladder is exposed to the majority of the prescribed dose, and frequently a considerable part of the rectum is in the treatment field. By contrast, IMRT is a well-developed technique where critical organs just around the planning target volume (PTV) can be very well protected despite an irregular shaped PTV (11) . Field-infield (FIF) radiotherapy operates in the reverse way to inverse IMRT and is accepted as static IMRT.…”

Section: Introductionmentioning

confidence: 99%

“…By applying an appropriate number of segments on 3D-CRT, a FIF plan can be obtained, and the negative effects of CRT in terms of conformity and homogeneity can be eliminated. Attempts have been made to determine which technique is superior with regard to target coverage, homogeneity, conformity and normal tissue dose (7,10,11) .…”

Section: Introductionmentioning

confidence: 99%

Dosimetric evaluation of field-in-field and sliding-window IMRT in endometrium cancer patients with a new approach for the conformity index

Özseven

Özkan

2020

Int J Radiat Res

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Background: Purpose of the study is to evaluate field-in-field (FIF) and slidingwindow intensity modulated radiation therapy (SW-IMRT) treatment plans in terms of homogeneity index (HI), conformity index (CI) and normal tissue doses for organs at risk (OAR) in patients with endometrial carcinoma along with deriving a new expression for CI. Materials and Methods: Four different FIF plans with different MLC (multi-leaf collimator) margins and SW-IMRT plan were compared in 20 endometrial cancer patients who underwent adjuvant pelvic radiotherapy with 50.4 Gy in 28 fractions. Normal tissue doses were assessed for OAR from dose volume histograms (DVHs). HI and CI values were calculated according to the reports of International Commission on Radiation Units and Measurements (ICRU)-83, Radiation Therapy Oncology Group (RTOG) 1993 and ICRU-62. A new CI was developed and named CIOPT standing for optimized conformity index. Results: SW-IMRT provided a significantly better CI in comparison to other FIF plans (p< 0.001). Conventional-FIF (C-FIF) was the most homogeneous plan compared to all other FIF plans and SW-IMRT (p≤0.001). The absolute volume of small intestine that received ≥45 Gy (V45) and doses received by a 30% volume of rectum (D30) were dramatically reduced in SW-IMRT (p < 0.001). Conclusion: MLC margins had a substantial influence on OAR doses, HI and CI. A close proximity of CI OPT to 1 indicated that this formulation of CI was a useful plan evaluation tool, which was also compatible with the RTOG 1993 and ICRU-62 reports.

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Dosimetric comparison of different treatment planning techniques with International Commission on Radiation Units and Measurements Report-83 recommendations in adjuvant pelvic radiotherapy of gynecological malignancies

Cited by 5 publications

References 2 publications

The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review

Dosimetric evaluation of field-in-field and sliding-window IMRT in endometrium cancer patients with a new approach for the conformity index

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