Dosimetric comparison between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in the treatment of different stages of nasopharyngeal carcinoma

Ibrahim, Mohamed S.; Attalla, Ehab M.; Naggar, Mostafa El; Elshemey, Wael M.

doi:10.1017/s1460396918000377

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Compared to photon-based therapy, including IMRT, dose-comparison studies reported lower doses to organs at risk and lower estimated normal tissue complication probability (NTCP) while improving dose coverage and conformality of the target volume when PBT is used. [12][13][14][15][16] Thus, the prospect of better toxicity outcomes when PBT is used to treat NPC is enticing.…”

Section: Introductionmentioning

confidence: 99%

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Yahya

Salleh

Nasir

et al. 2023

Asia-Pac J Clncl Oncology

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BackgroundProton and carbon‐ion therapy may spare normal tissues in regions with many critical structures surrounding the target volume. As toxicity outcome data are emerging, we aimed to synthesize the published data for the toxicity outcomes of proton or carbon‐ion therapy (together known as particle beam therapy [PBT]) for primary nasopharyngeal carcinoma (NPC).Materials and methodsWe searched PubMed and Scopus electronic databases to identify original studies reporting toxicity outcomes following PBT of primary NPC. Quality assessment was performed using NIH's Quality Assessment Tool. Reports were extracted for information on demographics, main results, and clinical and dose factors correlates. Meta‐analysis was performed using the random‐effects model.ResultsTwelve studies were selected (six using mixed particle‐photon beams, five performed comparisons to photon‐based therapy). The pooled event rates for acute grade ≥2 toxicities mucositis, dermatitis, xerostomia weight loss are 46% (95% confidence interval [95% CI]—29%–64%, I2 = 87%), 47% (95% CI—28%–67%, I2 = 87%), 16% (95% CI—9%–29%, I2 = 76%), and 36% (95% CI—27%–47%, I2 = 45%), respectively. Only one late endpoint (xerostomia grade ≥2) has sufficient data for analysis with pooled event rate of 9% (95% CI—3%–29%, I2 = 77%), lower than intensity‐modulated radiotherapy 27% (95% CI—10%–54%, I2 = 95%). For most endpoints with significant differences between the PBT and photon‐based therapies, PBT resulted in better outcomes. In two studies where dose distribution was studied, doses to the organs at risk were independent risk factors for toxicities.ConclusionPBT may reduce the risk of acute toxicities for patients treated for primary NPC, likely due to dose reduction to critical structures. The pooled event rate for toxicities derived in this study can be a guide for patient counseling.

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Section: Introductionmentioning

confidence: 99%

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Yahya

Salleh

Nasir

et al. 2023

Asia-Pac J Clncl Oncology

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“…A multitude of different-intensity beamlets confine the radiation beam, IMRT optimization is used inverse planning used which is a computer algorithm that adjusts the beam weighting and blocking to achieve an optimal plan and dose constrain [11]. Compared to conventional radiation therapy, intensity modulated radiotherapy (IMRT) protects nearby essential organs more effectively and achieves more conformal dose coverage for the target volume [12]. The steep and shoot IMRT provides radiation doses by using many defined multiple fixed beam angles.…”

Section: Introductionmentioning

confidence: 99%

effect of field number on intensity modulated radiation therapy plan quality in head and neck cancer

Hasan

Tahir

Aloosi

2022

ijhs

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Background: Radiotherapy of head and neck cancer is a difficult process because of the complex anatomy and close proximity of various organs at risk (OARs). This study aimed to assess the impact of field number of intensity modulated radiation therapy (IMRT) technique on the quality of the treatment of the head and neck cancer patient.. Methods and materials: The CT scans of thirteen head and neck cancer patients were selected at the Zhianawa Cancer Center (ZCC). The Monaco treatment planning system (TPS) V5.51.10 with the Monte Carlo (XVMC) algorithm V1.6 were utilized to generate nine and eleven field IMRT plans, all plans were carried out on an ELEKTAMLCi2 linear accelerator. The effect of field number was assessed by planning target volume (PTV) coverage, homogeneity index (HI), conformity index (CI), OARs dose, the monitor units (MUs), and delivery time. Results: The 11F-IMRT had improved tumor coverage and better spared ipsilateral and contralateral optic nerves, on the contrary the doses to the were above acceptance limit value. The CI of 11F-IMRT was better than 9F-IMRT, while the HI was similar. The 9F-IMRT had a reduced treatment time by 37.7 %, although increased MUs by 12.8%.

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“…On the other hand, a wide range of tumors including prostate cancer, breast carcinoma, small cell lung cancer (SCLC), ovarian cancer, and many more can be treated using surgery and chemotherapy along with radiotherapy side by side [3]. A variety of imaging techniques can be utilized for treatment using radiotherapies such as Computed tomography (CT) scan, three-dimensional-Conformal Radiotherapy (3D-CRT), Intensity Modulated Radiotherapy (IMRT), Image-guided Radiotherapy (IGRT), Rapid Arc or VMAT and Cyberknife and GammaKnife [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation and validation of tungsten fiducial marker-based image-guided radiotherapy

Shahid¹,

Mukhtar²,

Rizvi³

et al. 2021

Biomed. Phys. Eng. Express

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In this research work, a simple homemade cubic phantom was designed to validate the Image-Guided Radiotherapy (IGRT) set up and verified with the help of tungsten fiducial markers (size 2–3 mm) inserted into the cubic phantom. Phantom made up of Styrofoam, was scanned with the help of 16 slice Toshiba CT scanner where each slice was of 1 mm thickness and HU level set to −1000. A radio-opaque contrast medium was rubbed on the phantom to visualize the scanner images. Once the iso-center had been marked on a phantom with the help of in-room positioning laser and the fields (RT-LAT and AP) were applied on the contoured body of the phantom in Varian’s ARIA-11 Eclipse dosimeter software, the same position of the phantom was reproduced on Varian’s Linear Accelerator DHX. Known shifts of 3.0 to 30.0 mm from the marked iso-center were applied on the phantom by moving the couch in all six directions one by one. On each applied couch shift, an x-ray image of the phantom was acquired with the help of an MV portal imager of Linac in AP and RT-LAT direction. This image was superimposed with a reference image of phantom and shift accuracy calculated by ARIA-11 software was noted down. It turned out that irrespective of the position of the phantom on the couch, the calculated corrected shift and deviation from reference position was always between ± 1–2 mm which is the required accuracy for IGRT according to International Atomic Energy Agency (IAEA). This process was repeated 40 times and each time, the corrected shift came out to be ± 1–2 mm. We can conclude that our system is safe and accurate enough to perfectly position the actual patient for IGRT.

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Dosimetric comparison between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in the treatment of different stages of nasopharyngeal carcinoma

Cited by 3 publications

References 31 publications

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

effect of field number on intensity modulated radiation therapy plan quality in head and neck cancer

Evaluation and validation of tungsten fiducial marker-based image-guided radiotherapy

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