Dosimetric analysis of the carousel setup for the exposure of rats at 1.62 GHz

Schönborn, Frank; Pokovic, K.; Kuster, Niels

doi:10.1002/bem.10153

Cited by 30 publications

(19 citation statements)

References 12 publications

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“…There are two ways to estimate local SARs: by taking measurements of temperature [3,4] or the electrical field [6], or by simulation using a numerical phantom [6,7]. Measurements have the drawback of limited spatial precision, and that for brain and other vital organs they can only be taken from dead animals, so that the degree to which they are really applicable to living tissues is questionable.…”

Section: Discussionmentioning

confidence: 99%

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An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

López-Martín¹,

Bregáins²,

Jorge-Barreiro³

et al. 2008

PIER

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Abstract-We describe an experimental set-up for exposure of small animals to radiofrequency standing waves that allows direct measurement of the power absorbed by the animal. Essentially, the setup consists of a metallic box containing an antenna and experimental animal immobilized in a methacrylate holder; a signal generator feeding the antenna; and a power meter. In addition, the box can also contain a video camera to record the animal's behaviour, and a receiving antenna (connected externally to a power meter and a spectrum analyser) to detect undesired (external) radiation and possible harmonics of the radiating system. The absorbed power measurement trivially allows calculation of whole-body mean SAR from the animal's weight; and assuming local SARs to be proportional to whole-body mean SAR, the latter can be used to adjust organ-specific SAR predictions obtained by simulation using a commercial FDTD program with a numerical phantom. The use of the system is illustrated by application to rats given subconvulsive doses of picrotoxin to induce a seizure-prone state analogous to epilepsy: levels of the neuronal activity marker c-Fos in the frontal and piriform cortex of picrotoxin-treated rats exposed to 900 MHz GSM radiation were twice as high as those of unexposed animals.

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Section: Discussionmentioning

confidence: 99%

“…Specific absorption rates (SARs) at given locations in the animal are calculated either from thermal [3][4][5] or electrical field [5,6] measurements, or by simulation using a numerical phantom [6,7]; and whole-body SARs can be calculated by integration of the local SARs.…”

Section: Introductionmentioning

confidence: 99%

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

López-Martín¹,

Bregáins²,

Jorge-Barreiro³

et al. 2008

PIER

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show abstract

“…Similarly, other voxel-based rat models based on CT and MRI were developed for dosimetric analysis in experiments of electromagnetic exposure. 34,35 Most voxelbased rat models were developed from CT scans. This includes models based on a 248 g SD rat, 17 a 310 g Wistar rat, 39 three Fischer 344 rats having 126, 263, and 359 g body weight, 32 and three rats having weights of 115, 314, and 472 g produced by the National Institute of Information and Communications Technology (NICT).…”

Section: Of Huazhongmentioning

confidence: 99%

Development of computational small animal models and their applications in preclinical imaging and therapy research

Xie

Zaidi

2015

Med. Phys.

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The development of multimodality preclinical imaging techniques and the rapid growth of realistic computer simulation tools have promoted the construction and application of computational laboratory animal models in preclinical research. Since the early 1990s, over 120 realistic computational animal models have been reported in the literature and used as surrogates to characterize the anatomy of actual animals for the simulation of preclinical studies involving the use of bioluminescence tomography, fluorescence molecular tomography, positron emission tomography, single-photon emission computed tomography, microcomputed tomography, magnetic resonance imaging, and optical imaging. Other applications include electromagnetic field simulation, ionizing and nonionizing radiation dosimetry, and the development and evaluation of new methodologies for multimodality image coregistration, segmentation, and reconstruction of small animal images. This paper provides a comprehensive review of the history and fundamental technologies used for the development of computational small animal models with a particular focus on their application in preclinical imaging as well as nonionizing and ionizing radiation dosimetry calculations. An overview of the overall process involved in the design of these models, including the fundamental elements used for the construction of different types of computational models, the identification of original anatomical data, the simulation tools used for solving various computational problems, and the applications of computational animal models in preclinical research. The authors also analyze the characteristics of categories of computational models (stylized, voxel-based, and boundary representation) and discuss the technical challenges faced at the present time as well as research needs in the future. C 2016 American Association of Physicists in Medicine. [http://dx

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“…The FDTD method was used to compute SAR inside the mouse as described (Schonborn et al, 2004). The size of a mouse for simulation is 8 cm in length, 3.5 cm in height, and 3.5 cm in width.…”

Section: Local Exposure System For Mobile Phone Frequency Radiationmentioning

confidence: 99%

Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain

et al. 2008

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Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mobile phone frequency radiation. We established a carousel-type exposure chamber for 849 MHz or 1763 MHz of mobile phone RF radiation to expose RF to the heads of C57BL mice. In this chamber, animals were irradiated intermittently at 7.8 W/kg for a maximum of 12 months. During this period, the body weights of 3 groups-sham, 849 MHz RF, and 1763 MHz RF-did not show any differences between groups. The brain tissues were obtained from 3 groups at 6 months and 12 months to examine the differences in histology and cell proliferation between control and RF exposure groups, but we could not find any change upon RF radiation. Likewise, we could not find changes in the expression and distribution of NeuN and GFAP in hippocampus and cerebellum, or in cell death by TUNEL assay in RF exposure groups. From these data, we conclude that the chronic exposure to 849 MHz and 1763 MHz RF radiation at a 7.8 W/kg specific absorption rate (SAR) could not induce cellular alterations such as proliferation, death, and reactive gliosis.

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Dosimetric analysis of the carousel setup for the exposure of rats at 1.62 GHz

Cited by 30 publications

References 12 publications

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

Development of computational small animal models and their applications in preclinical imaging and therapy research

Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain

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