Dosificación de antibióticos en el tratamiento de las infecciones por SARM en pacientes con insuficiencia renal aguda sometidos a técnicas continuas de depuración extrarrenal

The dosage of drugs in patients requiring continuous renal replacement therapy need to be adjusted based on a number of variables that that affect pharmacokinetics (PK) including patient weight, CRRT modality (convention, vs. diffusion), blood and/or effluent flow, hemofilter characteristics, physiochemical drug properties, volume of distribution, protein binding and half-life as well as residual renal function. There is a paucity of data on PK studies in children with acute kidney injury requiring CRRT. When possible, therapeutic drug monitoring should be utilized for those medications where serum drug concentrations can be obtained in a clinically relevant time frame. Also, a patient-centered team approach that includes an intensive care unit pharmacist is recommended to prevent medication-related errors and enhance safe and effective medication use is highly recommended. The aim of this article is to review the current guidelines for drug dosing in critically ill children who require continuous venovenous hemofiltration.

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“…AKI affects both distribution and elimination of many drugs (57)(58)(59)(60)(61)(62)(63). CRRT also impacts on PK parameters in many ways.…”

Section: Crrt Impact On Pk Parametersmentioning

confidence: 99%

“…Glycopeptides (vancomycin) has a large molecular weigh nearly 1550 Daltons with volume distribution of 0.3.8 L/kg and protein binding of 30% (57). The normal function kidneys clear about 70% of the drug.…”

Section: Crrt Impact On Pk Parametersmentioning

confidence: 99%