Dose–volume-related dysphagia after constrictor muscles definition in head and neck cancer intensity-modulated radiation treatment

Abstract

We used recent guidelines to define dose constraints of the PCs and CM. Two results emerge in the present analysis: the superior PC influences late dysphagia, while the middle PC influences acute dysphagia.

Cone-beam computed tomography in lung stereotactic ablative radiation therapy: predictive parameters of early response

“…In fact, this topic was largely investigated to minimize healthy tissue toxicity, focalizing the high dose to a smaller tumour volume. [27][28][29][30][31] Concerning lung RT, in a small series of 38 patients affected by unresectable NSCLC and treated with concomitant chemo-conventional RT, tumour volume response evaluated by means of weekly CBCT was associated with a longer OS. 17 Unfortunately, no measured CBCT cut-off tumour response was determined for a better understanding of the behaviour or prediction of therapeutic outcomes.…”

Volumetric modulated arc therapy (VMAT) and simultaneous integrated boost in head-and-neck cancer: is there a place for critical swallowing structures dose sparing?

“…The most predictive dosimetric indices for the PCMs were found to be the mean dose [14][15][16][17][18][19] and the volume receiving more than 60 Gy 14,18 and 65 Gy 14,31 in the uPCM. Similarly, the most predictive dosimetric indices for the SGL were the mean dose 17,20 and the volume receiving .50 Gy.…”

Impact of weight loss in patients with head and neck carcinoma undergoing radiotherapy: is it an underestimated phenomenon? A radiation oncologist’s perspective

“…11,21 It would be desirable to have a prognostic nomogram for weight loss including clinical and dosimetric parameters, and depending on the results the estimated risk for an individual patient could be evaluated. Finally, several authors [22][23][24][25][26][27][28][29] have evaluated swallowing dysfunction after RT and attempted to determine the dosimetric (radiation dose-volume) factors correlating with swallowing toxicity. These results are summarized in Table 1.…”

“…Indeed, there were no complications when the larynx and the inferior constrictor received a mean dose below 48 and 54 Gy, respectively. According to Mazzola et al 23 the superior PC has a major role in late dysphagia (mean doses ⩾ 50 Gy being correlated with dysphagia at 3 and 6 months after RT). Other authors have reported similar results.…”