Dose Volume Distribution in Digital Breast Tomosynthesis: A Phantom Study

Sarno, Antonio; Masi, Marica; Antonelli, Nadua; Lillo, Francesca Di; Mettivier, Giovanni; Castriconi, R.; Russo, Paolo

doi:10.1109/trpms.2017.2705727

Cited by 18 publications

(15 citation statements)

References 22 publications

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“…Notwithstanding the abovementioned inherent issues with GafChromic™ film, the use of this dosimeter technology in heterogeneous phantoms to assess the dose distribution appears feasible (if sufficient entrance air kerma is delivered) and it confirms previous conclusions of the work of Sarno et al…”

Section: Discussionsupporting

confidence: 82%

Internal breast dosimetry in mammography: Monte Carlo validation in homogeneous and anthropomorphic breast phantoms with a clinical mammography system

2018

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PurposeTo validate Monte Carlo (MC)‐based breast dosimetry estimations using both a homogeneous and a 3D anthropomorphic breast phantom under polyenergetic irradiation for internal breast dosimetry purposes.MethodsExperimental measurements were performed with a clinical digital mammography system (Mammomat Inspiration, Siemens Healthcare), using the x‐ray spectrum selected by the automatic exposure control and a tube current‐exposure time product of 360 mAs. A homogeneous 50% glandular breast phantom and a 3D anthropomorphic breast phantom were used to investigate the dose at different depths (range 0–4 cm with 1 cm steps) for the homogeneous case and at a depth of 2.25 cm for the anthropomorphic case. Local dose deposition was measured using thermoluminescent dosimeters (TLD), metal oxide semiconductor field‐effect transistor dosimeters (MOSFET), and GafChromic™ films. A Geant4‐based MC simulation was modified to match the clinical experimental setup. Thirty sensitive volumes (3.2 × 3.2 × 0.38 mm3) on the axial‐phantom plane were included at each depth in the simulation to characterize the internal dose variation and compare it to the experimental TLD and MOSFET measurements. The experimental 2D dose maps obtained with the GafChromic™ films were compared to the simulated 2D dose distributions.ResultsDue to the energy dependence of the dosimeters and due to x‐ray beam hardening, dosimeters based on these three technologies have to be calibrated at each depth of the phantom. As expected, the dose was found to decrease with increasing phantom depth, with the reduction being ~93% after 4 cm for the homogeneous breast phantom. The 2D dose map showed nonuniformities in the dose distribution in the axial plane of the phantom. The mean combined standard uncertainty increased with phantom depth by up to 5.3% for TLD, 6.3% for MOSFET, and 9.6% for GafChromic™ film. In the case of a heterogeneous phantom, the dosimeters are able to detect local dose gradient variations. In particular, GafChromic™ film showed local dose variations of about 46% at the boundaries of two materials.ConclusionsResults showed a good agreement between experimental measurements (with TLD and MOSFET) and MC data for both homogeneous and anthropomorphic breast phantoms. Larger discrepancies are found when comparing the GafChromic™ dose values to the MC results due to the inherent less precise nature of the former.MC validations in a heterogeneous background at the level of local dose deposition and in absolute terms play a fundamental role in the development of an accurate method to estimate radiation dose. The potential introduction of a breast dosimetry model involving a nonhomogeneous glandular/adipose tissue composition makes the validation of internal dose distributions estimates crucial.

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Section: Discussionsupporting

confidence: 82%

Internal breast dosimetry in mammography: Monte Carlo validation in homogeneous and anthropomorphic breast phantoms with a clinical mammography system

2018

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“…Among the commercially available physical anthropomorphic phantoms, one can mention the 'Rachel' anthropomorphic breast phantom, Gammex 169 and the BR3D breast imaging phantom model 020 as well as the BR3D and the CIRS 073 (www.cirsinc.com/). The Rachel phantom is limited to a use in planar x-ray imaging and currently not available commercially, while the BR3D is manufactured specifically for breast tomosynthesis (Sarno et al 2017b). The multi-modality breast biopsy and sonographic trainer CIRS 073 mimics the heterogeneous appearance of breast tissue under various breast imaging modalities, and has cystic and dense lesions embedded within the breast background.…”

Section: Danail Ivanovmentioning

confidence: 99%

Suitability of low density materials for 3D printing of physical breast phantoms

et al. 2018

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Breast physical phantoms are a basic tool for the assessment and verification of performance standards in daily clinical practice of x-ray breast imaging modalities. They are also invaluable in testing and evaluation of new x-ray breast modalities to be potentially established, e.g. breast computed tomography, dual-energy breast CT and phase-contrast mammography and tomography. Nowadays, there is a lack or there are only a limited number of breast physical phantoms available for this purpose.The aim of this study is to explore a range of 3D printing materials such as resins, PLA, ABS, Nylon etc, to determine their attenuation and refractive properties, and to finally compare them to the properties of the breast tissues: adipose, glandular and skin.To achieve this goal, step-wedge phantoms were computationally modeled and then manufactured using stereolithographic and fused-deposition modeling technologies. X-ray images of the phantoms were acquired, using monochromatic beam at ID17, ESRF, Grenoble for three energies-30 keV, 45 keV and 60 keV. Experimental data were further processed to obtain the linear attenuation coefficients of these materials. Comparison with theoretical data for the linear attenuation coefficients and the refractive indexes for breast tissues was performed.From the studied materials, most of the resins, Nylon, Hybrid, PET-G show absorption properties close to the glandular tissue, while ABS shows absorption characteristics close to these of the adipose tissue. For phase-contrast imaging, it turns out that the ABS combined with resin-based materials to represent the adipose and glandular tissues, respectively may be a good combination for manufacturing of a phantom suitable for these studies.These results can be used for the design and the construction of a new physical anthropomorphic phantom of the breast with improved anatomical and radiological characteristics dedicated for advanced mammography imaging techniques implemented at higher photon energies.

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“…A MC code for MGD calculation in X-ray breast imaging was developed and presented in previous papers [19,[21][22][23][24]. It is based on GEANT4 ver.…”

Section: Codementioning

confidence: 99%

“…The Monte Carlo code, adopted in the case of homogeneous breast models, was largely validated versus both literature data and measurements [19,21,23]. In particular, it was validated versus data presented in the AAPM Task Group 195, cases I-III [35].…”

Section: Code Validationmentioning

confidence: 99%

Homogeneous vs. patient specific breast models for Monte Carlo evaluation of mean glandular dose in mammography

et al. 2018

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Dose Volume Distribution in Digital Breast Tomosynthesis: A Phantom Study

Cited by 18 publications

References 22 publications

Internal breast dosimetry in mammography: Monte Carlo validation in homogeneous and anthropomorphic breast phantoms with a clinical mammography system

Internal breast dosimetry in mammography: Monte Carlo validation in homogeneous and anthropomorphic breast phantoms with a clinical mammography system

Suitability of low density materials for 3D printing of physical breast phantoms

Homogeneous vs. patient specific breast models for Monte Carlo evaluation of mean glandular dose in mammography

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