Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy

Treatment outcomes with hypofractionated high-dose radiation therapy for prostate cancer

“…However, even with these caveats, the present data reinforce the idea that it is better to use a restrictive constraint than not, and it can be a helpful parameter to reduce toxicity. 17 Thus, although some readers could argue that radiotherapy technique used in the present study is overpassed in some developed countries, this HypoHD-RT schema with 3D-CRT could be the extreme utility to treat prostate cancer in low-income countries. Additionally, it is possible to think or suppose that these results tend to improve with the use of IMRT and IGRT.…”

Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

“…ART had been used clinically for prostate cancer since 1997, with a total of 1269 patients reported as treated at six different institutions [11,12,[13][14][15][16][17][18][19][20][21]. For the reviewed studies reporting CTV extension, the volume included prostate only in 405 patients, prostate and parts of the seminal vesicles in 649 patients and prostate, seminal vesicles and pelvic lymph nodes in one patient.…”

“…The adaptation strategy and timing applied to the majority (1186) of the prostate patients was offline re-plan/re-optimization after the initial 1-2 weeks of treatment to adjust to patient-specific prostate motion relative to bony anatomy ( Table 2, Figures 2 and 3) [11][12][13][14][15][16][17][18]. This ART strategy was used in three single institutional studies.…”

“…This ART strategy was used in three single institutional studies. The earliest implementations, and the pioneers of ART for prostate cancer, were conducted at Beaumont Hospital, US, where 962 patients were treated between the years 1997-2006 [9][10][11][12][13][14][15][16]22]. The target treated was prostate only for 42% of the patients with the remaining 58% receiving irradiation of both prostate and seminal vesicles.…”

A Novel Method for the Evaluation of Uncertainty in Dose–Volume Histogram Computation

“…Some DVH values are studied also, and their value with uncertainty is computed from DeVH. A number of dose-volume parameters has been proved to have predictive value for certain side effects, according to the literature 23,24,25,26,27 : V20 and V30 for lungs, V65 for bladder, V60 or V72 for rectum in IMRT prostate treatments. Special fractionation schemes for prostate treatments have been developed in our institution, being the standard for conventional conformal radiotherapy 50 Gy in 16 fractions in 22 days 28 , and a simultaneous boost technique for IMRT treatments with 54 Gy (PTV1), 57 Gy (PTV2) and 60 Gy (PTV3) in 3 Gy fractions 29 .…”