“…To read more about this research see the following reviews: Arnold et al, 2 , Stevens et al, 3 Stevens et al, 4 Kanarek, 5 Weiss, 6 and Millichap and Yee, 7 and a 2012 meta analysis by Nigg et al 8 One thing that seems clear from the behavioral studies is that a greater proportion of children reacted to higher doses (≥50 mg) of AFCs 9-12 than to lower amounts (<50 mg). 13-19 Other important factors were age of the child (younger children were more reactive than older children) and time of evaluation (1-3 hours postchallenge were more revealing than later evaluations). Participants in these studies were thought by their parents to be reactive to AFCs and were diagnosed with “hyperkinesis,” “hyperactivity,” or “behavior problems,” which included restlessness, irritability, and sleep problems.…”