Dose-Response Studies With Protirelin

Garbutt, James C.; Mayo, James P.; Little, Karley Y.; Gillette, Gregory M.; Mason, George A.; Dew, Bess; Prange, Arthur J.

doi:10.1001/archpsyc.1994.03950110035006

Cited by 24 publications

(7 citation statements)

References 56 publications

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“…Similar brief increases in BP to those we found have consistently been reported fol- (10) 80 ( lowing TRH doses ranging from 0.1 mg to a high of 0.5 mg kg-, [7,[16][17][18], whereas a significant tachycardia has only occasionally been noted [17,18]. Dose-reponse studies of the hormonal effects of TRH indicate that maximal prolactin responses occur at doses of > 100 ,ug and thyroid stimulating hormone responses at 2 400,ug of TRH [19]. These pituitary responses depend on the peripheral concentration of TRH, which may not be relevant for the cardiovasular effects [11].…”

Section: Discussionsupporting

confidence: 87%

The cardiovascular and subjective effects of thyrotropin releasing hormone (TRH) and a stable analogue, dimethyl proline‐TRH, in healthy volunteers.

Coupland

Bailey

Glue

et al. 1995

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 87%

The cardiovascular and subjective effects of thyrotropin releasing hormone (TRH) and a stable analogue, dimethyl proline‐TRH, in healthy volunteers.

Coupland

Bailey

Glue

et al. 1995

Brit J Clinical Pharma

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“…Furthermore, a blunted TSH response to TRH was reported in about 25–30% of depressed subjects compared to healthy ones [50–54]. One preeminent hypothesis to explain the above finding is that chronic TRH hypersecretion associated with depression leads to downregulation of pituitary TRH receptors [24, 53, 55, 56]. In support to this hypothesis are reports of elevated CSF concentrations of TRH in depressed patients [57, 58].…”

Section: Blunted Tsh Response and Abnormal Diurnal Rhythmmentioning

confidence: 99%

The Link between Thyroid Function and Depression

Hage

Azar

2012

Journal of Thyroid Research

429

176

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The relation between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4 levels, low T3, elevated rT3, a blunted TSH response to TRH, positive antithyroid antibodies, and elevated CSF TRH concentrations. In addition, thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressant drugs. However, the mechanisms underlying the interaction between thyroid function and depression remain to be further clarified. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship.

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“…injection of 50 µg protirelin (Relefact TRH 200/400, Hoechst Marion Roussell), which is one-eighth to a quarter dose of that used diagnostically in the thyrotropin-releasing hormone (TRH) test and well-tolerated in this dosage. Protirelin was given at the beginning of the experiment, thus producing the desired prolactin increase during the period of sexual arousal and orgasm (Garbutt et al 1994, Horita 1998. Consecutive increases of thyroxine and triiodothyronine occur with a certain latency.…”

Section: Pharmacological Prolactin Manipulationmentioning

confidence: 99%

Effects of acute prolactin manipulation on sexual drive and function in males

Krüger

Haake²,

Haverkamp³

et al. 2003

Journal of Endocrinology

126

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The neuroendocrine response to sexual activity in humans is characterized by a pronounced orgasm-dependent increase of plasma levels of prolactin. In contrast to the well-known inhibitory effects of chronic hyperprolactinemia on sexual drive and function, the impact of acute prolactin alterations on human sexual physiology is unknown. Therefore, this study was designed to investigate the effects of acute manipulation of plasma prolactin on sexual behavior.Ten healthy males participated in a single-blind, placebo-controlled, balanced cross-over design. Prolactin levels were pharmacologically increased to high levels (protirelin, 50 µg i.v.) or reduced to low physiological concentrations (cabergoline, 0·5 mg p.o.). Sexual arousal and orgasm were then induced by an erotic film and masturbation. In addition to continuous neuroendocrine and cardiovascular recordings, the quality and intensity of the acute sexual drive, arousal, orgasm and refractory period were assessed by extensive psychometric measures.Administration of cabergoline decreased prolactin levels and significantly enhanced all parameters of sexual drive (P,0·05), function (P,0·01) and positive perception of the refractory period (P,0·01). Administration of protirelin increased prolactin concentrations and produced small, but not significant reductions of sexual parameters. The sexual effects observed from cabergoline were completely abrogated by coadministration of protirelin.Although different pharmacological sites of action of prolactin-altering drugs have to be considered, these data demonstrate that acute changes in prolactin plasma levels may be one factor modulating sexual drive and function. Therefore, besides a neuroendocrine reproductive reflex, a post-orgasmic prolactin increase may represent one factor modulating central nervous system centers controlling sexual drive and behavior. These findings may offer a new pharmacological approach for the treatment of sexual disorders.

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Dose-Response Studies With Protirelin

Cited by 24 publications

References 56 publications

The cardiovascular and subjective effects of thyrotropin releasing hormone (TRH) and a stable analogue, dimethyl proline‐TRH, in healthy volunteers.

The cardiovascular and subjective effects of thyrotropin releasing hormone (TRH) and a stable analogue, dimethyl proline‐TRH, in healthy volunteers.

The Link between Thyroid Function and Depression

Effects of acute prolactin manipulation on sexual drive and function in males

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