Dose Response Relationships Beween Chromosome Damage and Absorbed Radiation

Chee, C. A. K.; Ilbery, P. L. T.

doi:10.1111/j.1440-1673.1975.tb01922.x

Cited by 5 publications

(2 citation statements)

References 16 publications

(6 reference statements)

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“…Ž 1975 , after radiation accidents Dolphin et al, 1970; . Dvoreckij et al, 1971;Brewen et al, 1972;Pjatkin, 1976 , Ž in patients undergoing radiotherapy Tamura et al, 1970;Pyatkin et al, 1972b;Schmid et al, 1974a;Silberstein et al, 1974;Chee and Ilbery, 1975;Watson andGillies, . Ž 1975 or therapy with radionuclides Arbor, 1964;Cantolino et al, 1966;De la Chapelle et al, 1972;Stevenson et al, 1973;Blackwell et al, 1974;Boyd et al, 1974; .…”

Section: ( ) Deõelopment and Standardization Of The Dicentric Dic Assaymentioning

confidence: 99%

How radiation-specific is the dicentric assay?

Hoffmann

Schmitz-Feuerhake

1999

J Expo Sci Environ Epidemiol

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Question: Quantitative cytogenetic analysis of structural chromosome aberrations in human peripheral blood lymphocytes is widely used as an assay to Ž . detect and quantify exposure to a variety of clastogens. Unstable chromosome rearrangements, dicentric chromosomes dic and centric ring chromosomes Ž . Ž . centric r , are routinely used as biomarkers to assess human exposure to ionizing radiation "biological dosimetry" . In the moderate-to high-dose range many authors consider the dic assay sufficiently radiation-specific for both practical and legal purposes. However, specificity has never been evaluated in quantitative terms. The high sensitivity of the assay would in principle allow for applications in the range of low-dose exposure which has been a major concern in epidemiologic studies. Validity of the assay then critically depends on specificity. Methods: A mathematical model is proposed which includes as parameters the decline of dicentric aberrations in ÕiÕo, the linear dose coefficient for the induction of dic and the average total radiation exposure of the population. To assess radiation-specificity of the dic assay the equilibrium dicentric rate due to radiation is compared to measurements of the background rate of dic in unexposed controls. Results: Environmental and medical radiation combined account for at least about 80% of the average background level of dicentrics. Conclusion: It is concluded that the dicentric assay is highly specific for ionizing radiation and can therefore be used to assess prior exposure in the dose range of interest in environmental epidemiology.

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Section: ( ) Deõelopment and Standardization Of The Dicentric Dic Assaymentioning

confidence: 99%

How radiation-specific is the dicentric assay?

Hoffmann

Schmitz-Feuerhake

1999

J Expo Sci Environ Epidemiol

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show abstract

“…In 1968 the laboratory set out its cytogenetic techniques for radiobiological procedures (Barnes and llbery). Since then we have reported our work on the form and function of the lymphocyte as a radiation dosimeter (Barnes et al,197 1 ), concerning blood lymphocyte replicating ability as a measurement of radiation dosage (Ilbery et al, 1971, Chee et nl., 1974, and for the determination of dose response relationships between chromosome damage and absorbed radiation (Chee and Ilbery, 1975 ) .…”

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confidence: 99%