Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongji Cohort

Lai, Xuefeng; Yang, Liangle; Légaré, Sébastien; Angileri, Francesca; Chen, Xuguang; Fang, Qin; Yang, Handong; Zhang, Ce; Li, Xiulou; Min, Xinwen; Xu, Chengwei; Yuan, Jing; He, Meian; Wu, Tangchun; Zhang, Xiaomin

doi:10.1016/j.ijcard.2016.09.035

Cited by 31 publications

(34 citation statements)

References 43 publications

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“…Incident CHD was defined as the first hospital admission with an occurrence of non-fatal myocardial infarction, stable and unstable angina pectoris, coronary artery bypass graft or percutaneous coronary intervention and CHD death [26]. The diagnosis of CHD was based on health-care service system of Dongfeng Motor Corporation and electronic medical records in the hospitals of Dongfeng Motor Corporation made by cardiologists.…”

Section: Methodsmentioning

confidence: 99%

“…Diseases were verified by self-reported physician diagnosis, medical examination, or current use of medication. Diabetes was defined as individuals with a previous self-reported physician diagnosis of diabetes, or fasting glucose level ≥ 7.0 mmol/L, or current use of oral hypoglycemic medication or insulin; Hypertension was defined as subjects with blood pressure ≥ 140/90 mmHg at medical examination, or taking antihypertensive medication, or a self-reported of physician diagnosis of hypertension; Hyperlipidemia was defined as participant with a previous physician diagnosis of hyperlipidemia, or current use of lip-lowering medication, or total cholesterol (TC) > 5.72 mmol/L or total triglycerides (TG) > 1.70 mmol/L at medical examination [25, 26]. …”

Section: Methodsmentioning

confidence: 99%

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Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men: Results from the Dongfeng-Tongji cohort

Zhang

Yuan

et al. 2017

PLoS ONE

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BackgroundEpidemiologic studies have found that moderate alcohol consumption was associated with a decreased risk of coronary heart disease (CHD) incidence. Nevertheless, whether the drinking pattern is associated with CHD incidence still remains inconclusive.MethodsWe included 8,469 Chinese men aged 45–81 years, who were free of CHD, stroke, or cancer at baseline from Dongfeng-Tongji cohort. A semi-structured questionnaire was used to collect information on alcohol consumption and other covariates. Cox proportional hazard regression model was applied to estimate the multivariable-adjusted hazard rations (HRs) and 95% confidence intervals (95% CIs).ResultsDuring an average of 4.36 years of follow-up, we identified 959 incident CHD events. Compared with non-drinkers, the multivariable-adjusted HR (95% CI) of CHD incidence was 0.84 (0.71–0.98) in current drinkers. With respect to drinking pattern, men who consumed 20.01–40 grams ethanol once a time had a 24% lower risk of incident CHD (HR = 0.76, 95% CI = 0.62, 0.94) compared with non-drinkers. The adjusted HRs (95% CI) of CHD incidence were 0.80 (0.65, 0.99), 1.02 (0.84, 1.22), and 0.75 (0.59–0.96) in subjects who consumed 0.01–10, 10.01–30, and > 30 grams ethanol per day, respectively. Participants who consumed 20.01–40 grams ethanol per time with less than 5 times per week had the lowest risk of CHD incidence (HR = 0.73, 95% CI = 0.52, 0.96). No significant associations were observed between type or frequency of alcohol consumption and CHD incidence.ConclusionsDrinking was associated with a lower risk of CHD incidence in middle-aged and older Chinese men and moderate quantity of ethanol amounts once a time with lower frequency could been considered as a healthy drinking pattern, which might modify the relationship between alcohol consumption and incident CHD.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men: Results from the Dongfeng-Tongji cohort

Zhang

Yuan

et al. 2017

PLoS ONE

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“…Physical activity was defined as those who took exercise more than 20 minutes per day and at least 3 times per week over half of a year 39 . Dietary factors included vegetable and fruit intake (rarely, or at least once per day) 40 . BMI was calculated as weight in kilograms divided by height squared in meters and rounded to the nearest tenth.…”

Section: Methodsmentioning

confidence: 99%

Association between education and the risk of incident coronary heart disease among middle-aged and older Chinese: the Dongfeng-Tongji Cohort

Wang

Yuan

Song

et al. 2017

Sci Rep

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Educational achievement was related to cardiovascular disease in some western populations, but prospective evidence on the relationship between education and the risk of incident coronary heart disease (CHD) in Asians is scarce. We aimed to explore this association and the potential modifying effect of major CHD risk factors related to education in middle-aged and older Chinese adults. We included 18,551 participants with mean age 62.8 years at baseline between September 2008 and June 2010, and followed the population until October 2013. Cox proportional hazard models and log-binomial regression models were used for multivariate analyses. Compared with participants with low education, the adjusted hazard ratio (HR) and 95% confidence interval (95% CI) for incident CHD in those with high education was 0.89 (95% CI: 0.80, 0.98). In addition, such inverse association between education and the risk of incident CHD was more evident among individuals who were more than 60 years, physically active, overweight, and hypertension. Besides, decreases in the relative index of inequality with high education versus low education were from 0.83 to 0.76 for hypertension, from 0.85 to 0.82 for diabetes. In conclusion, education was inversely associated with the risk of incident CHD among middle-aged and older Chinese adults.

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“…UA is a final enzymatic product of purinemetabolism; an abnormal level of UA may hint a potential renal dysfunction or a variety of other metabolic disorders 42 , 43 . UA has been reported to be positively associated with risk of incident CHD, cardiovascular disease, and death in multiple epidemiological studies including in our cohort 44 – 47 . These evidence together, suggested that renal dysfunction may increase the risk of CHD in Chinese populations, and serum biomarkers, namely eGFR, BUN, and UA, can provide a power risk prediction in CHD prevention.…”

Section: Discussionmentioning

confidence: 58%

Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study

Jiang

et al. 2017

Sci Rep

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Estimated glomerular filtration rate (eGFR) has been reported to be associated with risk of incident coronary heart disease (CHD), and blood urea nitrogen (BUN) has been shown to be a strong predictor of mortality in patients with heart failure (HF). However, such epidemiological evidence from Chinese population was still limited. We used Cox proportional-hazards regression models to investigate the associations of eGFR and BUN with risk of incident CHD in the prospective Dongfeng-Tongji (DFTJ) cohort. After fully adjusted for potential confounders, a 10-unit decline in eGFR was associated with higher risk for CHD (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.01–1.09); compared with individuals with normal eGFR levels (eGFR ≥ 90 ml/min per 1.73 m2), individuals with a mild-to-severe eGFR decline (15 to 60 ml/min per 1.73 m2) were at significantly greater risk for CHD (HR 1.25, 95% CI 1.05–1.48; P = 0.011). Compared with individuals in the lowest tertile of BUN, those in the highest tertile were at significantly greater risk for CHD (HR 1.17, 95% CI 1.03–1.33; P = 0.014). In conclusion, a mild-to-severe decline in eGFR or a raised level of BUN might be associated with increased risk of incident CHD in middle-aged and elderly Chinese populations.

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Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongji Cohort

Cited by 31 publications

References 43 publications

Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men: Results from the Dongfeng-Tongji cohort

Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men: Results from the Dongfeng-Tongji cohort

Association between education and the risk of incident coronary heart disease among middle-aged and older Chinese: the Dongfeng-Tongji Cohort

Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study

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