Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial

Larsen, Mads S.; Witard, Oliver C.; Holm, Lars; Scaife, Paula; Hansen, Rikke; Smith, Kenneth; Tipton, Kevin D.; Mose, Maike; Bengtsen, Mads B.; Lauritsen, Katrine M.; Mikkelsen, Ulla R.; Hansen, Mette

doi:10.1016/j.tjnut.2023.08.011

The Journal of Nutrition

2023

DOI: 10.1016/j.tjnut.2023.08.011

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Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial

Mads S. Larsen,

Oliver C. Witard,

Lars Holm

et al.

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2024

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Cited by 2 publications

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Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with postmenopause

McKenna,

Askow,

Paulussen

et al. 2024

Journal of Applied Physiology

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Feeding and resistance exercise stimulate myofibrillar protein synthesis rates (MPS) in healthy adults. This anabolic characterization of 'healthy adults' has been namely focused on males. Therefore, the purpose of this study was to examine the temporal responses of MPS and anabolic signaling to resistance exercise alone or combined with the ingestion of protein in post-menopausal females and compare postabsorptive rates with young females. Sixteen females (60 ± 7 y; BMI = 26 ± 12 kg·m-2) completed an acute bout of unilateral resistance exercise before consuming either: a fortified whey protein supplement (WHEY) or water. Participants received primed continuous infusions of L-[ ring-13C6]phenylalanine with bilateral muscle biopsies before and after treatment ingestion at 2 h and 4 h in non-exercised and exercised legs. Resistance exercise transiently increased MPS above baseline at 0-2 h in the water condition (P = 0.007). Feeding after exercise resulted in a late phase (2-4 h) increase in MPS in the WHEY condition ( P = 0.005). In both conditions, exercise did not enhance the cumulative (0-4 h) MPS response. In the non-exercised leg, MPS did not differ at 0-2 h, 2-4 h, or 0-4 h of the measurement periods (all, P > 0.05). Likewise, there were no changes in the phosphorylation of p70S6K, AMPKα, or total and phosphorylated yes-associated protein on Ser127. Post-absorptive MPS were lower in pre-menopausal vs. post-menopausal females ( P = 0.023). We show that resistance exercise-induced changes in MPS are temporally regulated, but do not result in greater cumulative (0-4 h) MPS in post-menopausal women.

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Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with postmenopause

McKenna,

Askow,

Paulussen

et al. 2024

Journal of Applied Physiology

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The Impact of Protein in Post-Menopausal Women on Muscle Mass and Strength: A Narrative Review

Black,

Matkin-Hussey

2024

Physiologia

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Background: Menopause is a significant period in the life of a female; many hormonal and lifestyle changes occur, which can have a catastrophic effect on their health and well-being. Amongst these changes is the loss of muscle mass and strength. Resistance training is recommended for post-menopausal women; however, the role of protein in muscle mass and strength in this population is unclear. Methods: This narrative review discusses the research evidence regarding daily protein needs, dose and timings of intake, and protein quality. Results: Observational and interventional studies suggest post-menopausal females should ingest at least the RDA 0.8 g·kg−1·d−1 of protein, the dosing at each meal maybe important. Both whey and soy protein may provide some benefit to muscle strength. Conclusions: Overall, there is limited evidence and not of high quality, making it difficult to make inferences about the protein needs of post-menopausal females.

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Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial

Cited by 2 publications

References 50 publications

Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with postmenopause

Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with postmenopause

The Impact of Protein in Post-Menopausal Women on Muscle Mass and Strength: A Narrative Review

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