Dose-response curves after in vivo experimental chemotherapy: Influence of rouze of administration on biological outcomes

Although hematoporphyrin derivative (HPD) and its ‘purers’ variety Photofrin II are the most widely used tissue sensitizers in both clinical and experimental photodynamic therapy (PDT), quantitative studies of tissue distribution have been few. We have extracted and measured Photofrin II in several organs of the normal mouse including those of relevance to urological practice. In view of the reported heterogeneities in the distribution within tissues of various cytotoxics when administered intraperitoneally. we have compared results for Photofrin II given by this route with those for intravenous injection. Although both routes of administration gave equally consistent results, differences in absolute tissue concentration as a function of time after injection were found for several but not all tissues. Furthermore, the porphyrin accumulated following intravenous administration seemed to contain more of the non‐polar photodynamically active component than that accumulated following the intraperitoneal route. We attempt to explain these differences by reference to published data on porphyrin binding to serum proteins.

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“…injections for several normal tissues (e.g. Moore, 1985). Such variations would influence the results of PDT.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Serum Kinetics and Tissue Distribution of Photofrin Ii Following Intravenous and Intraperitoneal Injection in the Mouse

Pantelides¹,

Moore

Blacklock³

1989

Photochem & Photobiology

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Pharmacokinetics in experimental and clinical chemotherapy

Workman

1986

Cancer Chemother. Pharmacol.

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Effects of sodium cyanate in mice bearing B16 melanoma

Lea

Luke

Velázquez

et al. 1986

Cancer Chemother. Pharmacol.

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Sodium cyanate injected IP at a dose level of 200 or 250 mg/kg caused a 90% or greater inhibition of the incorporation of [3H]thymidine into DNA of B16 melanoma transplanted SC in mice. Despite the inhibitory effect of sodium cyanate on precursor incorporation into DNA, no significant effect on host survival was observed when sodium cyanate was administered as a single agent in the diet, in drinking water, or by IP injection to mice that had received IP transplants of B16 melanoma. The action of melphalan and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in prolonging the survival time of melanoma-bearing mice was not enhanced by combined treatment with sodium cyanate. However, combined injections of sodium cyanate and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) increased the survival of tumor-bearing mice significantly more than injections of BCNU alone at a lower dose than the maximum tolerated one. These data and other studies suggest that B16 melanoma may be less responsive to the action of sodium cyanate than are murine leukemic cells or rat hepatomas.

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Dose-response curves after in vivo experimental chemotherapy: Influence of rouze of administration on biological outcomes

Cited by 5 publications

References 2 publications

A Comparison of Serum Kinetics and Tissue Distribution of Photofrin Ii Following Intravenous and Intraperitoneal Injection in the Mouse

A Comparison of Serum Kinetics and Tissue Distribution of Photofrin Ii Following Intravenous and Intraperitoneal Injection in the Mouse

Pharmacokinetics in experimental and clinical chemotherapy

Effects of sodium cyanate in mice bearing B16 melanoma

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