Dose‐response Characteristics of Immunologic Unresponsiveness to Uv‐induced Tumors Produced by Uv Irradiation of Mice

DeFabo, Edward C.; Kripke, Margaret L.

doi:10.1111/j.1751-1097.1979.tb07372.x

Cited by 73 publications

(29 citation statements)

References 12 publications

(4 reference statements)

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“…This is contrary to reports in which conclusions are based on UV radiation-induced reductions in ETAF/IL-1 levels from in vitro experiments (37,38 (41). It has recently been reported that unirradiated skin from highdose UV radiation-exposed animals has normal Langerhans cell density and function (42) and, further, that the antigenpresenting cell defect described to be present in the spleens of UV radiation-exposed mice is due to the migration of such a cell from this central lymphoid compartment to peripheral sites (29).…”

Section: Discussioncontrasting

confidence: 99%

Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Gahring

Baltz

Pepys

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

131

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Section: Discussioncontrasting

confidence: 99%

Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Gahring

Baltz

Pepys

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

131

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“…UV suppression of CHS has been shown in humans (Hersey et al 1983;Kalimo et al 1983;Cooper et al 1992) as well as in experimental animals, indicating that this mechanism is relevant to human health. UVB-induced immune suppression is of potential importance in modulation of the immune response in UV-related diseases, e.g., skin cancer (Fisher and Kripke 1977;De Fabo and Kripke 1979;De Fabo and Kripke 1980) and certain infectious diseases (Giannini 1986;Howie et al 1986;Jeevan and Kripke 1989). We have previously demonstrated three phenotypes: namely, high, low, and intermediate susceptibility to UV suppression, based on UV dose-responses for suppression of CHS in 18 strains and substrains of inbred mice (Noonan and Hoffman 1994).…”

Section: Inmxluetlonmentioning

confidence: 99%

Control of UVB immunosuppression in the mouse by autosomal and sex-linked genes

Noonan

Hoffman

1994

Immunogenetics

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Irradiation with UVB (290-320 nm) initiates a systemic immunosuppression detectable as suppression of contact hypersensitivity (CHS). We investigated susceptibility to UV suppression in reciprocal F1-hybrid and backcross mice derived from BALB/c (low susceptibility) and C57BL/6 (high susceptibility) inbred strains. CB6F1 male mice exhibited high susceptibility and B6CF1 male mice exhibited low susceptibility, indicating a major X-linked effect in the genetic control of UV immune suppression. Females of either F1 hybrid showed intermediate suppression, consistent with random X-inactivation. A model of monogenic X-linked control was not sufficient, and evidence for the action of two genetically unlinked autosomal genes was found in parental backcross animals. Both sexes of (BALB/c x CB6F1) mice showed a 1 high:1 low ratio of phenotypes, indicating control by a major autosomal locus, Uvs1, confirmed by propagation of the high phenotype through selective backcrossing for nine generations to BALB/c. Uvs1 was not genetically linked to 12 chromosomal markers including the pigment genes b (brown) and c (albino). Backcross animals (C57BL/6 x CB6F1) showed a significant sex difference, male mice giving a 3 high:1 low ratio of phenotypes, compatible with the action of a second autosomal locus, Uvs2, in this hybrid. The findings are compatible with a model in which high phenotype (Uvs1b/Uvs1b) is dominant when subjected to recessive epistatis by the X-chromosome locus Uvs3, or by the autosomal locus Uvs2. The finding of genetic control by interacting autosomal and X-linked genes is unique. Genetically determined high susceptibility to UV immunosuppression may be an important risk factor for UV-related human diseases.

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“…We have previously found a major difference in susceptibility to UVB suppression between mouse strains, BALB/c mice requiring nearly six times more UV than C57BL/6 mice for 50% suppression of CHS . Because of the potential role of UVB-induced immune suppression in modulation of the immune response to environmental antigens and in UV-related diseases, e.g., skin cancer (Daynes and Spellman 1977;De Fabo and Kripke 1979;De Fabo and Kripke 1980;Fisher and Kripke 1977;Fisher and Kripke 1982), we have investigated further the differences in susceptibility to UV suppression between inbred mouse strains as an initial step in addressing the question of genetic control of this trait.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to immunosuppression by ultraviolet B radiation in the mouse

Noonan

Hoffman²

1994

Immunogenetics

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Irradiation with ultraviolet B (UVB; 290-320 nm) initiates systemic immunosuppression of contact hypersensitivity (CHS). UV dose-responses for suppression of CHS to trinitrochlorobenzene were established in 18 strains of inbred mice. Three phenotypes with significantly different susceptibilities to UV suppression were identified. The phenotypes were: high (HI) susceptibility, 50% suppression with 0.7-2.3 kJ/m2 UV (C57BL/6, C57BL/10, and C57L and NZB females); low (LO) susceptibility, 50% suppression with 9.6-12.3 kJ/m2 UV (BALB/c, AKR, SJL and NZW), and intermediate (INT) susceptibility, 50% suppression with 4.7-6.9 kJ/m2 UV (DBA/2, C57BR, C3H/HeJ, C3H/HeN, CBA/N and A/J). UV suppression was not correlated with skin pigmentation or with the magnitude of the CHS response in non-irradiated animals. Major histocompatibility complex (MHC) haplotype was not correlated with UV suppression in MHC congenic strains B10.D2/oSnJ, B10.D2/nSnJ, B10.BR/SgSnJ, and A.BY/SnJ. There were no sex differences in UV suppression in BALB/c, C57BL/6, or NZW animals. In the autoimmune NZB strain, however, male mice (LO) were seven times less sensitive to UV suppression than NZB female mice (HI). Both sexes of (NZB x NZW)F1 and (NZW x NZB)F1 mice were HI, supporting dominance of HI over LO. Thus there are genetic factors and interacting sex-limited factors determining susceptibility to UV suppression. These findings may be of relevance to UV-related diseases such as photosensitive lupus and skin cancer.

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Dose‐response Characteristics of Immunologic Unresponsiveness to Uv‐induced Tumors Produced by Uv Irradiation of Mice

Cited by 73 publications

References 12 publications

Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Control of UVB immunosuppression in the mouse by autosomal and sex-linked genes

Susceptibility to immunosuppression by ultraviolet B radiation in the mouse

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