Dose-response and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure

Kwak, Ho-Seok; Han, Ji Yoon; Choi, June-Seek; Ahn, Hyun Kyong; Kwak, Dong Wook; Lee, Yeon-Kyung; Koh, Sun-Young; Jeong, Goun; Velázquez-Armenta, E. Yadira; Nava-Ocampo, Alejandro A

doi:10.1002/pd.4374

Cited by 17 publications

(16 citation statements)

References 27 publications

(33 reference statements)

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“…The detection has been focused in the use of questionnaires about alcohol consumption and biomarkers of exposure [6]. Up to date, the determination of fatty acid ethyl esters (FAEEs) or ethyl glucuronide (EtG) in meconium or maternal hair is the best procedure to identify exposed newborns, but with a cut off value in the range of heavy drinking population [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prenatal ethanol exposure and placental hCG and IGF2 expression

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Prenatal ethanol exposure and placental hCG and IGF2 expression

et al. 2015

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“…Appropriately sensitive and specific maternal biomarkers for recent alcohol consumption are being developed. At birth, it is possible to detect some patterns of prenatal alcohol exposure by infant biomarkers (Bakhireva et al., ; Kwak et al., ). It is also possible to identify children with physical features of FASD in the newborn period through a targeted dysmorphology examination (Jones and Smith, ).…”

mentioning

confidence: 99%

Second‐Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders

Montag

Hull

Yevtushok

et al. 2016

Alcoholism Clin & Exp Res

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Background Early detection of fetal alcohol spectrum disorders (FASDs) is desirable to allow earlier and more comprehensive interventions to be initiated for the mother and infant. We examined prenatal ultrasound as an early method of detecting markers of the physical features and neurobehavioral deficits characteristic of FASD. Methods A longitudinal cohort of pregnant women in Ukraine was recruited as part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Women were enrolled into a moderately to heavy-alcohol-exposed group or a low- or no-alcohol exposure group and were followed to pregnancy outcome. In the second trimester, a fetal ultrasound was performed to measure Trans Cerebellar Diameter (TCD), Occipital Frontal Diameter (OFD), Caval-Calvarial Distance (CCD), Frontothalamic Distance (FTD), Inter-orbital Distance (IOD), Outer-orbital Distance (OOD), and Orbital Diameter (OD). Live born infants received a dysmorphological exam and a neurobehavioral evaluation using the Bayley Scales of Infant Development. These data were used to classify infants with respect to FASD. Comparisons were made on the ultrasound measures between those with and without features of FASD, adjusting for gestational age at ultrasound and maternal smoking. Results 233 mother/child dyads were included. Children classified as FASD had significantly longer IOD, and lower FTD/IOD, OFD/IOD and FTD/OD ratios (p <0.05). Children with a Bayley score <85 had significantly shorter FTD, longer IOD, lower OFD/IOD and FTD/IOD ratios (p <0.05). In general mean differences were small. Ultrasound variables alone predicted <10% of the variance in the FASD outcome. Conclusions Some ultrasound measurements were associated with FASD, selected facial features of the disorder, and lower neurobehavioral scores. However, mean differences were relatively small, making it difficult to predict affected children based solely on these measures. It may be advantageous to combine these easily obtained ultrasound measures with other data to aid in identifying high risk for an FASD outcome.

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“…In contrast, a growing number of epidemiological studies have consistently found a lack of short- and long-term adverse maternal and fetal outcomes when exposure occurred at low or very low levels ( Kelly et al 2013 , Han et al 2012 , O’Leary et al 2013 , Robinson et al 2010 ). Aligned with these findings, our group recently reported a study where the sum of nine different FAEEs was found to be an unreliable composed biomarker of low prenatal alcohol exposure ( Kwak et al 2014a ). However, the possibility that at least one of the FAEEs remained linearly correlated to the intensity of alcohol ingestion was not explored.…”

Section: Introductionmentioning

confidence: 70%

Linear Versus Non-Linear Dose-Response Relationship Between Prenatal Alcohol Exposure and Meconium Concentration of Nine Different Fatty Acid Ethyl Esters

Yang¹,

Kwak²,

Han³

et al. 2015

Dose-Response

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Presence of individual fatty acid ethyl esters (FAEEs) in meconium is considered to be a reliable biomarker of prenatal alcohol exposure, and their concentration has been found to be linearly associated with poor postnatal development, supporting the widely extended idea that ethanol is a non-threshold teratogen. However, a growing number of epidemiological studies have consistently found a lack of adverse short- and long-term fetal outcomes at low exposure levels. We therefore aimed to investigate the relationship between the concentration of individual FAEEs and prenatal alcohol exposure in meconium samples collected within the first 6 to 12?h after birth from 182 babies born to abstainer mothers and from 54 babies born to women who self-reported either light or moderate alcohol ingestion in the second or third trimester of pregnancy. In most cases, the individual FAEE concentrations were negligible and not significantly different (P >0.05) between exposed and control babies. The concentrations appeared to increase linearly with the dose only in the few babies born to mothers who reported >3 drinks/week. These results provide evidence that the correlation between prenatal alcohol exposure and individual FAEE concentrations in meconium is non-linear shape, with a threshold probably at 3 drinks/week.

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Dose-response and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure

Cited by 17 publications

References 27 publications

Prenatal ethanol exposure and placental hCG and IGF2 expression

Prenatal ethanol exposure and placental hCG and IGF2 expression

Second‐Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders

Linear Versus Non-Linear Dose-Response Relationship Between Prenatal Alcohol Exposure and Meconium Concentration of Nine Different Fatty Acid Ethyl Esters

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