Dose-Related Visual-Field Defects in Patients Receiving Puva Therapy

8‐Methoxypsoralen and neurological disorders: from dysosmia to migraine

“…Altogether, (i) our first case‐report of 8‐MOP‐induced dysosmia (1); (ii) the three cases of visual disorders reported by Fenton and Wilkinson (6) where all the symptoms were consistent with migraine attack; and (iii) the case reported herein, widen the spectrum of 8‐MOP‐induced neurological disorders with sensory disturbances from isolated dysosmia to migraine attack.…”

“…Three cases of visual‐field defects related to the use of oral 8‐MOP with a dose‐dependent relationship have already been described by Fenton and Wilkinson (6): the first patient experienced nausea and photophobia with scotoma, the second, with a history of migraine, experienced nausea, pain in the right eye and bilateral tunnel vision and the third had nausea and tunnel vision.…”

Eye protection for ultraviolet B phototherapy and psoralen ultraviolet A patients

“…Eye protection is required during ultraviolet (UV) therapy in order to prevent both acute and chronic side effects. Photokeratoconjunctivitis (snow‐blindness) is well acknowledged as an acute phototoxic effect of UVR (1), with the onset of symptoms usually occurring a few hours after UVR exposure and lasting between 24 and 48 h. Patients typically complain of pain, which may be severe, transient visual disturbance and may sometimes have uncontrolled blinking (blepharospasm). Although studies have indicated that acutely it is overexposure to UVB that is the most damaging to the cornea and conjunctiva (2), it is recognized that systemic psoralen ultraviolet A (PUVA) may also cause photokeratoconjunctivitis (1, 3).…”

Ultraviolet radiation‐blocking characteristics of contact lenses: relevance to eye protection for psoralen‐sensitised patients

“…Accepted for publication April 27, 1999 Assessment of the risk of ophthalmological adverse effects related to the combination of systemically administered psoralen and ultraviolet A (UVA) exposure (PUVA) is difficult due to the paucity of long-term controlled studies in humans. Acute side effects such as photokeratoconjunctivitis (1) and transient visual disturbance (2) are easily related to PUVA, but delayed PUVA effects on the lens are more difficult to substantiate as cataract formation is so common past the fifth decade (3).…”