Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs

Kuang, Hongxuan; Zhou, Weizheng; Zeng, Yingwei; Xu, Da; Zhu, Wanqi; Lin, Shengjie; Fan, Ruifang

doi:10.1016/j.chemosphere.2022.134201

Cited by 8 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After maternal perinatal dietary intake of PAHs, adult male rats showed increased anxiety-related behaviors and decreased metabolism in several different brain regions . Notably, a recent study that exposed mice to ambient concentrations of PAHs with intradermal administration found that ingesting low concentrations of PAHs did not cause significant neurotoxicity . This is different from what other studies have found, mainly because of the dose.…”

Section: The Health Impact Of Pah Derivatives On Humans and Animalscontrasting

confidence: 67%

See 1 more Smart Citation

Influence of Exposure Pathways on Tissue Distribution and Health Impact of Polycyclic Aromatic Hydrocarbon Derivatives

et al. 2023

Environ. Health

View full text Add to dashboard Cite

The oxygen (OPAHs), nitro (NPAHs), hydroxyl (OH-PAHs), and alkylated (APAHs) derivatives of polycyclic aromatic hydrocarbon (PAHs) are ubiquitous pollutants in the environment. The concentrations of NPAHs, OPAHs, OH-PAHs, and APAHs are lower than that of PAHs in the environment, but the carcinogenic abilities of the derivatives are usually 10 to 1,000-fold higher than that of parent PAHs. There are three main pathways for the exposure of polycyclic aromatic compounds to humans, including inhalation, direct contact, and ingestion. After exposure by inhalation, they are mainly distributed in the lungs, affecting lung function and causing inflammation, asthma, etc. Due to the digestive system’s strong capacity for metabolism, intake of PAHs and the derivatives is primarily distributed in the digestive system and metabolized there. And it may lead to dysplasia of these organs and even to cancer. The skin is the primary site of direct contact with PAH derivatives. PAH derivatives can enter the bloodstream through all three contact pathways, thereby accumulating in various organs. This study aimed to summarize the influence of exposure pathways on tissue distribution and the health impact of PAH derivatives to provide references for future research and evaluation on public health.

show abstract

Section: The Health Impact Of Pah Derivatives On Humans and Animalscontrasting

confidence: 67%

“…173 Notably, a recent study that exposed mice to ambient concentrations of PAHs with intradermal administration found that ingesting low concentrations of PAHs did not cause significant neurotoxicity. 174 This is different from what other studies have found, mainly because of the dose.…”

Section: Other Toxicitiescontrasting

confidence: 61%

Influence of Exposure Pathways on Tissue Distribution and Health Impact of Polycyclic Aromatic Hydrocarbon Derivatives

et al. 2023

Environ. Health

View full text Add to dashboard Cite

show abstract

“…At the mildly polluted dose, the exposure doses of PAHs in mice and rats in this study were 14.39 μg kg −1 BW and 3.60 μg kg −1 BW respectively. Studies have shown that the toxicity of PAHs was not significant at this dose (Kuang et al ., 2022). So the group that only accumulated PAHs without PDT treatment was not set up in the animal experiment (the oyster treatment method was the same as L‐S‐).…”

Section: Discussionmentioning

confidence: 99%

Degradation of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons in oysters and toxicity evaluation of PDT‐treated oysters

Zhi

Tang

et al. 2022

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary This study investigated the degradation effect of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons (PAHs) in oysters, and evaluated the safety of PDT‐treated oysters through acute and subacute toxicity experiments. The results demonstrated that curcumin‐mediated PDT could effectively degrade multi‐component PAHs in oysters, the maximum removal efficiency could reach 80.20% (10 μmol L−1 curcumin concentration and 54 J cm−2 light energy density). Acute toxicity experiment revealed PDT‐treated oysters did not cause any mortality and adverse symptoms in mice at an oral dose of 40 g kg−1 BW. Besides, after being treated at the dose of 10 g kg−1 BW for 28 days, the rats showed no obvious abnormal change in the indicators including the body weight, food utilisation, urology, haematology, serum biochemistry, organ index and histopathology. These findings show curcumin‐mediated PDT is a potentially efficacious method to degrade PAHs in oysters, and PDT‐treated oysters have high edible safety.

show abstract

“…[6][7][8] Although petroleum products are of low toxicity, local, systemic toxicity, and mutagenicity occur in mice at high doses. 9 These toxic effects are attributed to the aromatic constituents of these substances. Some PAHs such as BaP can inhibit thyroid peroxidase, which is a rate-limiting enzyme in thyroid hormone biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, monitoring exposure in pregnant women may be an acceptable substitute to evaluate the fetus's exposure. 9 The thyroid gland is a very important organ because of the influential roles it plays in growth, early development, and metabolism. 15 Exposure to crude oil toxicants, especially during critical and sensitive developmental periods such as pregnancy, may lead to several health consequences that can manifest in both the pre-natal and post-natal life of individuals, and has the potential to be transmitted from one generation to another.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Emokpae,

Ogana

2024

Explor Res Hypothesis Med

View full text Add to dashboard Cite

Background and objectives: Harm caused by crude oil spillage and its associated environmental toxicants manifests slowly. This study examined the impact of crude oil environmental toxicants on neonates' thyroid and cognitive functions in crude oil-producing communities. Methods:The case-control study comprised 55 crude oil-exposed expectant mothers and 33 non-crude oil-exposed expectant mothers as controls. Serum Benzo Pyrene Dihydrodiol Epoxide (BPDE), triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were assayed in expectant mothers and neonates. Intelligence quotient and APGAR scores were determined in the children using Fagan's test of infant intelligence.Results: Serum TSH (p < 0.05) and BPDE (p < 0.001) were higher, while T3 and T3/T4 ratio were significantly lower (p < 0.001) in exposed pregnant women compared to the control. Cord blood TSH and T3/T4 ratio were lower (p < 0.001) while T4 and BDPE were higher (p < 0.001) in prenatally exposed neonates than prenatally non-exposed infants. Serum TSH correlated with BDPE (R 2 = 0.080, p < 0.036) and APGAR score (R 2 = 0.341, p < 0.012), while T3 and T4 were not associated with BDPE and APGAR score. TSH correlated with T3 (R 2 = 0.0.082, p < 0.05), T3 correlated with T4 (R2 = 0.111, p < 0.013) and TSH (R 2 = 0.082, p < 0.05). Exactly 54.5% (30/55) of prenatally exposed neonates had a low intelligence quotient compared to 36.4% (12/33) in prenatally non-exposed neonates. Conclusion:Crude oil and associated environmental pollutants might significantly affect the thyroid function. Environmental surveillance, biomonitoring and environmental cleanup are emphasized. Future research on the mechanisms of the observed toxicological effects on thyroid hormones and targeted protection of pregnant women and their offspring is suggested.

show abstract

Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs

Cited by 8 publications

References 48 publications

Influence of Exposure Pathways on Tissue Distribution and Health Impact of Polycyclic Aromatic Hydrocarbon Derivatives

Influence of Exposure Pathways on Tissue Distribution and Health Impact of Polycyclic Aromatic Hydrocarbon Derivatives

Degradation of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons in oysters and toxicity evaluation of PDT‐treated oysters

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Contact Info

Product

Resources

About