Dose-finding study of intravenous midazolam for sedation and amnesia during spinal anesthesia in patients premedicated with intramuscular midazolam

Abstract

For sedation and amnesia of the patients aged 20-50 years in spinal anesthesia with about 1 h duration receiving intramuscular midazolam 0.06 mg.kg(-1) as a premedication, intravenous midazolam 0.02 mg.kg(-1) might be effective and safe.

Intramuscular compared to intravenous midazolam for paediatric sedation: A study on cardiopulmonary safety and effectiveness

“…[20] In another research conducted in Japan by Nishiyama et al on 20-25 years old patients, midazolam as a premedication was administrated and they concluded that "receiving IM midazolam 0.06 mg/kg 1 h before operation as a premedication following IV midazolam 0.02 mg/kg might be effective and safe." [21] This finding and this dosage is concomitant with our result although the studied population is different with our study.…”

Comparison of Ilioinguinal-İliohypogastric Nerve Block versus Spinal Anesthesia Techniques for Single Sided Inguinal Herniorrhaphy

“…[16] Midazolam im uygulamalarında sedasyon etkisi 15 dakikada başlamakta ve yaklaşık 60 dakika sürmektedir. [17] Propofol analjezik etkisi olmayan, sedasyonda da kullanılabilen nonopioid intravenöz anestezik ilaç-tır. [18] Bizim çalışmamızda, IHNB uygulanan hastaların yaklaşık yarısında ameliyatta sedasyon gereksinimi olmuştur.…”

“…Hareketle VAS değerleri arasında fark bulunmamış-tır. Hastanede kalış süresi SA+IHNB+cerrahi yara infiltrasyonu grubunda SA grubuna göre (18 [14][15][16][17][18][19][20][21][22][23][24][25][26]ve 23 [17][18][19][20][21][22][23][24][25][26] saat, ortanca [min-maks]) daha kısa gözlenmiştir. Sonuçta SA+IHNB+%0.75 ropivakain ile cerrahi yara yeri infiltrasyonunun ameliyat sonrası ilk üç saat ağrıyı azalttığını ve hastanede kalış süresini kısalttığı belirtilmektedir.…”

Assessment of psychological tension after premedication by measurement of salivary chromogranin A

“…In our operating rooms (ORs), midazolam and butorphanol are used as a sedative or analgesic, respectively, in relatively healthy patients, expecting an amnesic effect in the former drug and a ceiling effect on respiratory depression in the latter drug. [9,10]. Of these drugs, however, there are many other reports supporting the superiority of midazolam [1,2,5,6,11,12].…”