Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions

Hanks, Gerald E.; Hanlon, Alexandra L.; Schultheiss, Timothy E.; Pinover, Wayne H.; Movsas, Benjamin; Epstein, Barry E.; Hunt, Margie A.

doi:10.1016/s0360-3016(98)00089-3

Cited by 397 publications

(183 citation statements)

References 24 publications

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“…The target volumes and technique of RT planning have been described previously. 25,26 In general, a four-field technique using megavoltage irradiation was used. For favorable-risk patients with a T1/T2 classification and a Gleason score of 2-6, only the prostate was treated.…”

Section: Treatmentmentioning

confidence: 99%

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Jacob

Hanlon

Horwitz

et al. 2004

Cancer

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A coupled simulation of the flue gas and process gas side of the convection section of a steam cracker is performed, making use of the CFD software package Fluent. A detailed overview of the operating mode of the different heat exchangers suspended in the convection section is obtained. The asymmetric inlet flow field of the flue gas in the convection section, and the radiation from the convection section walls leads to large differences in outlet temperatures of the tubes located in the same row. The flow fields and temperature fields in the tubes of a single heat exchanger differ significantly with e.g., outlet temperatures of the hydrocarbon‐steam mixture ranging from 820 K to 852 K. Moreover, the simulations reveal the presence of hot spots on the lowest tube row, possibly causing fouling. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Section: Treatmentmentioning

confidence: 99%

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Jacob

Hanlon

Horwitz

et al. 2004

Cancer

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“…In curative RT, the target volume of tissue irradiated to high dose must encompass the entire tumor and any microscopic extensions of disease but should be kept as small as possible to minimize damage to normal tissues. Advances in computer assisted 3D planning such as three-dimensional conformal radiotherapy (3DCRT), intensity modulated radiation therapy (IMRT) [3] and image guided radiation therapy (IGRT) facilitate delivery of higher radiation doses to the tumor [4,5] and increase normal tissue sparing. To exploit these advances, accurate target delineation is essential.…”

Section: Introductionmentioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

331

197

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“…( 1 ) By virtue of this capability, IMRT has enabled the delivery of conformal doses to the target while sparing the surrounding normal tissues, which can furthermore allow dose escalation — which is beneficial for the outcomes of radiotherapy. ( 2 – 5 ) …”

Section: Introductionmentioning

confidence: 99%

The dosimetric effect of mixed‐energy IMRT plans for prostate cancer

Park

Choi

et al. 2011

J Applied Clin Med Phys

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We investigated the effect of mixing high‐ and low‐energy photon beams on the quality of intensity‐modulated radiation therapy (IMRT) plans for patients with prostate cancer. Three different plans for each of twenty patients were generated using either 6 MV or 15 MV alone, and both 6 and 15 MV beams. All the planning parameters, goals, and constraints were set to be identical except beam energy. The dose distributions were similar in terms of target coverage, conformity, and homogeneity regardless of beam energy. The normalV70Gy of rectal wall in 6 MV, 15 MV and mixed‐energy plans was 16.7%, 17.9%, and 16.3%, respectively, while normalV40Gy was 55.6%, 53.2%, and 50%. The mean dose to femoral heads in 6 MV, 15 MV, and mixed‐energy plans were 31.7 Gy, 26.3 Gy, and 26.2 Gy, respectively. The integral dose of 6 MV plans was 7% larger than those of 15 MV or mixed‐energy plans. These results indicated that mixed‐energy IMRT plans could take advantage of the dosimetric characteristics of low‐ and high‐energy beams. Even though the reduction of dose to the organs at risk may not be clinically relevant, mixing energy in an IMRT plan for deep‐seated tumors can improve the overall plan quality.PACS number: 87.55.ne

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Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions

Cited by 397 publications

References 24 publications

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

The dosimetric effect of mixed‐energy IMRT plans for prostate cancer

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