Dose Enhancement in Radiotherapy by Novel Application Of Gadolinium Based MRI Contrast Agent Nanomagnetic Particles in Gel Dosimetry

Amirrashedi, Mahsa; Alam, Nader Riahi; Mostaar, Ahmad; Haghgoo, Soheila; Gorji, E; Jaberi, Ramin

doi:10.1007/978-3-319-19387-8_200

Cited by 8 publications

(9 citation statements)

References 28 publications

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“…Hence the theoretical dose enhancement should also be negligible. Experimental data agrees with the physical models (Amirrashedi et al, 2015; J. Cho et al, 2016). Smith et al (2015) used alanine dosimetry with dl ‐alanine impregnated with 5 nm GNPs (3% wt) for measurements under X‐ray, electron and proton irradiation.…”

Section: Physical Mechanismssupporting

confidence: 82%

Mechanisms of nanoparticle radiosensitization

Kempson

2020

WIREs Nanomed Nanobiotechnol

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Metal‐based nanoparticles applied to potentiating the effects of radiotherapy have drawn significant attention from the research community and are now available clinically. By improving our mechanistic understanding, nanoparticles are likely to evolve to provide very significant improvements in radiotherapy outcomes with only incremental increase in cost. This review critically assesses the inconsistent observations surrounding physical, physicochemical, chemical and biological mechanisms of radiosensitization. In doing so, a number of needs are identified for continuing research and are highlighted. The large degree of variability from one nanoparticle to another emphasizes that it is a mistake to generalize nanoparticle radiosensitizer mechanisms. Nanoparticle formulations should be considered in an analogous way as pharmacological agents and as a broad class of therapeutic agents, needing to be considered with a high degree of individuality with respect to their interactions and ultimate impact on radiobiological response. In the same way that no universal anti‐cancer drug exists, it is unlikely that a single nanoparticle formulation will lead to the best therapeutic outcomes for all cancers. The high degree of complexity and variability in mechanistic action provides notable opportunities for nanoparticle formulations to be optimized for specific indications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Section: Physical Mechanismssupporting

confidence: 82%

Mechanisms of nanoparticle radiosensitization

Kempson

2020

WIREs Nanomed Nanobiotechnol

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“…The dose enhancement ratios are in good agreement with the results of a previous study. 21 These results demonstrate that the presence of GONs increases hydroxyl radical production; moreover, the radiation enhancement effects of GONs on hydroxyl radical production in aqueous solutions induced by X-rays are dependent on dose and concentration. Studies have shown that oxidative stress produced by nanomaterials can be observed in multiple cell types.…”

mentioning

confidence: 72%

“…[18][19][20] The radiosensitization properties of GONs were first investigated by Amirrashedi et al in a gel-filled phantom, in which the maximum dose enhancement of GONs ranged from 15% to 24%. 21 Seo et al found that the GONs enhancement of the production of ROS under photon and proton irradiation was dose-dependent with a factor of 1.94 compared with that of the radiation-only control. Core-inner-valence ionization of GONs can de-excite electrons via potent Gd-Gd interatomic de-excitation processes.…”

Section: Introductionmentioning

confidence: 99%

<p>Ultra-small gadolinium oxide nanocrystal sensitization of non-small-cell lung cancer cells toward X-ray irradiation by promoting cytostatic autophagy</p>

Li¹,

Li²,

Jiang³

et al. 2019

IJN

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Background Gadolinium-based nanoparticles (GdNPs) have been used as theranostic sensitizers in clinical radiotherapy studies; however, the biomechanisms underlying the radio-sensitizing effects of GdNPs have yet to be determined. In this study, ultra-small gadolinium oxide nanocrystals (GONs) were employed to investigate their radiosensitizing effects and biological mechanisms in non-small-cell lung cancer (NSCLC) cells under X-ray irradiation. Method and materials GONs were synthesized using polyol method. Hydroxyl radical production, oxidative stress, and clonogenic survival after X-ray irradiation were used to evaluate the radiosensitizing effects of GONs. DNA double-strand breakage, cell cycle phase, and apoptosis and autophagy incidences were investigated in vitro to determine the radiosensitizing biomechanism of GONs under X-ray irradiation. Results GONs induced hydroxyl radical production and oxidative stress in a dose- and concentration-dependent manner in NSCLC cells after X-ray irradiation. The sensitizer enhancement ratios of GONs ranged between 19.3% and 26.3% for the NSCLC cells under investigation with a 10% survival rate compared with that of the cells treated with irradiation alone. Addition of 3-methyladenine to the cell medium decreased the incidence rate of autophagy and increased cell survival, supporting the idea that the GONs promoted cytostatic autophagy in NSCLC cells under X-ray irradiation. Conclusion This study examined the biological mechanisms underlying the radiosensitizing effects of GONs on NSCLC cells and presented the first evidence for the radiosensitizing effects of GONs via activation of cytostatic autophagy pathway following X-ray irradiation.

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“…GdNPs have high electron density. Therefore, ionizing radiation contains notes nanoparticles aqueous solution, in addition to the interaction between ionizing radiation and water can cause water molecules ionization and secondary electron emission, the incident particles and secondary electron interaction with Gd will also lead to request for nanoparticles electron emission increases around a few nanometer scale, electronic further solution of released from water molecules 104). Some scholars found that under photon and proton irradiation, the enhancement of ROS produced by GONs was dose-dependent, and the factor was 1.94 compared with radiation control alone.…”

Section: Common Sensitizing Agentmentioning

confidence: 99%

Application of Carbon Ion and Its Sensitizing Agent in Cancer Therapy: A Systematic Review

Wang

Chen

et al. 2021

Front. Oncol.

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Carbon ion radiation therapy (CIRT) is the most advanced radiation therapy (RT) available and offers new opportunities to improve cancer treatment and research. CIRT has a unique physical and biological advantage that allow them to kill tumor cells more accurately and intensively. So far, CIRT has been used in almost all types of malignant tumors, and showed good feasibility, safety and acceptable toxicity, indicating that CIRT has a wide range of development and application prospects. In addition, in order to improve the biological effect of CIRT, scientists are also trying to investigate related sensitizing agents to enhance the killing ability of tumor cells, which has attracted extensive attention. In this review, we tried to systematically review the rationale, advantages and problems, the clinical applications and the sensitizing agents of the CIRT. At the same time, the prospects of the CIRT in were prospected. We hope that this review will help researchers interested in CIRT, sensitizing agents, and radiotherapy to understand their magic more systematically and faster, and provide data reference and support for bioanalysis, clinical medicine, radiotherapy, heavy ion therapy, and nanoparticle diagnostics.

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Dose Enhancement in Radiotherapy by Novel Application Of Gadolinium Based MRI Contrast Agent Nanomagnetic Particles in Gel Dosimetry

Cited by 8 publications

References 28 publications

Mechanisms of nanoparticle radiosensitization

Mechanisms of nanoparticle radiosensitization

<p>Ultra-small gadolinium oxide nanocrystal sensitization of non-small-cell lung cancer cells toward X-ray irradiation by promoting cytostatic autophagy</p>

Application of Carbon Ion and Its Sensitizing Agent in Cancer Therapy: A Systematic Review

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