Dose‐effect relationship between brisk walking and blood pressure in Chinese occupational population with sedentary lifestyles

Yu, Yingxiang; Chang, Cuiqing; Wu, Yi‐Fan; Guo, Chengcheng; Xie, Liang

doi:10.1111/jch.14340

Cited by 6 publications

(4 citation statements)

References 29 publications

(63 reference statements)

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“…Regarding the independent predictors of hypertension progression in multivariate analysis (including smoking, 8,000-10,000 steps/day, abdominal obesity, OSAHS, WHR, and non-HDL-C levels), our results are mostly consistent with those of previous studies. 5,[43][44][45][46][47] Moreover, our data provide further support for serum HMGB2 as a novel risk biomarker of subclinical HMOD and reaffirm its potential as a therapeutic target in young adults with hypertension. Prior studies indicate that inflammation and hypertension are physiologically interrelated.…”

Section: Discussionsupporting

confidence: 69%

Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults

Wan

Liu

Xia

et al. 2022

Therapeutic Advances in Chronic Disease

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Background: Hypertension-mediated organ damage (HMOD) is an emerging problem among young adults. The potential role of chronic immune-mediated inflammation in the pathogenesis of HMOD is increasingly being recognized. High-mobility group box 2 (HMGB2) is known for its role in the modulation of innate immunity and exerts signaling functions that affect various inflammatory diseases. However, the association between HMGB2 and HMOD in young adults remains unclear. Objectives: The aim of this study was to explore the association between HMGB2 and subclinical HMOD in young adults. Design: This is a cross-sectional study. Methods: Body composition, carotid ultrasound, carotid-femoral PWV (cf-PWV) measures, echocardiography, serum HMGB2 levels, and serum classic cardiometabolic risk factors were measured in 988 untreated young adults. We estimated the risk related to serum HMGB2 using multivariable-adjusted linear and logistic regression models. Then, we conducted a pathway overrepresentation analysis to examine which key biological pathways may be linked to serum HMGB2 in young adults with HMOD. Results: Among the 988 untreated young adults, we identified four distinct hypertension phenotypes: normotension (40.0%), white-coat hypertension (16.0%), masked hypertension (20.9%), and sustained hypertension (23.1%). High levels of serum HMGB2 were related to increased carotid intima-media thickness (cIMT) and left ventricular mass index (LVMI), higher cf-PWV and blood pressure, and a lower estimated glomerular filtration rate (eGFR). Linear regression analysis showed that serum HMGB2 was positively associated with cf-PWV and negatively associated with eGFR in all patients. Multivariate analysis showed that high levels of serum HMGB2 were associated with high odds of subclinical HMOD (damage in at least one organ). Biological pathway analysis indicated that patients with high serum HMGB2 levels had increased activity of pathways, related to endothelial dysfunction, inflammatory processes, and atherosclerosis. Conclusion: High serum concentrations of HMGB2 are associated with an increased risk of subclinical HMOD in untreated young adults.

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Section: Discussionsupporting

confidence: 69%

Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults

Wan

Liu

Xia

et al. 2022

Therapeutic Advances in Chronic Disease

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“… 25 Whilst a recent narrative review also reported that a sedentary lifestyle is associated with impaired kidney function. 26 The possible mechanism underpinning the long-sitting adverse effects are abnormal blood pressure, 27 inflammation, 28 and metabolic syndrome, 29 and they can contribute to reduced renal function.…”

Section: Discussionmentioning

confidence: 99%

Examining the Links Between Physical Activity, Sitting Time, and Renal Function in T2DM Patients

Wang¹,

Yan²,

Pan³

et al. 2023

DMSO

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Background Sitting time and physical activity are related to renal function among type 2 diabetes mellitus (T2DM); however, the mechanism of how it contributes to renal function is not well understood. The current study attempts to explore the relationship between sitting time and renal function among T2DM patients, with a particular focus on the mediating role of physical activity. Methods This research uses the data of 1761 Chinese T2DM patients from Ningxia Province. Sitting time and physical activity were obtained during a face-to-face survey, and renal function was assessed by the estimated glomerular filtration rate (eGFR). The bootstrap method is used to test the mediating effect. Results The research found that sitting time was negatively associated with eGFR and physical activity after controlling for covariates. Physical activity was positively associated with eGFR. Physical activity has mediated the relationship between sitting time and eGFR among T2DM patients (explaining 16.1% of the total variance). Conclusion The present findings suggest that sitting time negatively affects eGFR among T2DM patients and provides new evidence that physical activity could attenuate the association between sitting time and eGFR. Hence, intervention strategies focusing on sitting time and physical activity should be paid more attention in the future.

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“…Body composition parameters were assessed based on bioimpedance methods using model MC-180 (Tanita Corporation, model MC-180, Japan ( 17 )), a well-established and validated technique. This measurement was performed during the menstrual period (seven days after expected menses) in the morning.…”

Section: Methodsmentioning

confidence: 99%

Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome

Zhang

Wang²,

Zhao³

et al. 2023

Front. Endocrinol.

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ObjectiveTo investigate how body fat influences glucose metabolism and hormone profiles in women with polycystic ovary syndrome (PCOS), compared to women without PCOS.MethodsWe conducted a cross-sectional study of 166 women with PCOS and 139 age-matched control women at Peking University Third Hospital (Beijing, China) from March 2016 to December 2021. All participants underwent bioimpedance rate assessment of clinical, anthropometric, hormonal, and metabolic features. In particular, body composition parameters were assessed, based on the methods used in a previous study. Homeostasis model assessment-insulin resistance (HOMA-IR) and other indices calculated from fasting glucose and insulin were used to measure insulin resistance. The hormonal profiles [follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), prolactin (PRL), total testosterone (T), and androstenedione (A2)] were assessed by using biochemical methods. Two subgroup analyses were conducted according to waist-to-hip ratio (WHR; < 0.85, non-central obesity and ≥ 0.85, central obesity) and body fat percentage (BFP; < 35% for lean and ≥35% for obesity). The indices above were analyzed using a two-sided t-test or Wilcoxon rank sum test. Linear regression was used to investigate the effects of body composition on metabolism and sex hormones in the PCOS and control groups.ResultsCompared to women without PCOS, women with PCOS and central obesity (P=0.021), PCOS and noncentral obesity (P<0.001), PCOS and high BFP (P<0.001), and PCOS and low BFP (P<0.001) had more severe glucose metabolism evaluated with HOMA-IR. Women with PCOS experienced greater insulin sensitivity impairment than did the normal population for every equal increase in BFP. LH, LH/FSH, total testosterone, and androstenedione were significantly higher in patients with PCOS than in healthy controls, regardless of WHR and BFP stratification. However, negative correlations existed between body fat indices (i.e., BFP and body mass index) and hormone indices (i.e., LH and androstenedione) in the PCOS group, but were absent in the control group.ConclusionsObese and non-obese women with PCOS have more severe insulin resistance and sex-hormone disorders than women without PCOS. The effect of body fat on sex-hormone disorders is only exist in women with PCOS. These findings suggested that PCOS clinical guidelines should be more specific to body fat.Clinical trial registrationhttps://clinicaltrials.gov/, Registration No. NCT04264832.

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Dose‐effect relationship between brisk walking and blood pressure in Chinese occupational population with sedentary lifestyles

Cited by 6 publications

References 29 publications

Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults

Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults

Examining the Links Between Physical Activity, Sitting Time, and Renal Function in T2DM Patients

Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome

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