Dose-effect and structure-activity relationships of haloquinoline toxicity towards Vibrio fischeri

Li, Min; Wang, Yayao; Ma, Lu; Yan, Xiaojing; Liu, Qian

doi:10.1007/s11356-021-16388-8

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Meanwhile, DEX was frequently detected in medical wastewater as a commonly used glucocorticoid. Moreover, the toxicity of HCQ to aquatic animals had also been reported ( Guo et al, 2017 ; Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 97%

Ultraviolet-coupled advanced oxidation processes for anti-COVID-19 drugs treatment: Degradation mechanisms, transformation products and toxicity evolution

Huang

Guo

2022

Chemosphere

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Section: Introductionmentioning

confidence: 97%

Ultraviolet-coupled advanced oxidation processes for anti-COVID-19 drugs treatment: Degradation mechanisms, transformation products and toxicity evolution

Huang

Guo

2022

Chemosphere

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“…The generally recognized international method of toxicity assessment is based on the use of choline esterase inhibition [17] and photobacterium cells, the level of bioluminescence intensity of which depends on the type and concentration of the toxin appearing in their microenvironment [18]. Generally, both methods give a quick response to the presence of toxic compounds.…”

Section: Introductionmentioning

confidence: 99%

Luminescent Bacteria as Bioindicators in Screening and Selection of Enzymes Detoxifying Various Mycotoxins

Efremenko,

Lyagin,

Stepanov

et al. 2024

Sensors

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Interest in enzymes capable of neutralizing various mycotoxins is quite high. The methods used for the screening and selection of enzymes that catalyze the detoxification of mycotoxins should be sensitive and fast. However toxic compounds can be generated under the action of such enzymes. Thus, the assessment of the overall reduction in the toxic properties of reaction media towards bioluminescent bacteria seems to be the most reasonable control method allowing a quick search for the effective enzymatic biocatalysts. The influence of a wide range of mycotoxins and glucanases, which hydrolyze toxins with different chemical structures, on the analytical characteristics of luminescent photobacteria as a biosensing element has been studied. Different glucanases (β-glucosidase and endoglucanase) were initially selected for reactions with 10 mycotoxins based on the results of molecular docking which was performed in silico with 20 mycotoxins. Finally, the biorecognizing luminescent cells were used to estimate the residual toxicity of reaction media with mycotoxins after their interaction with enzymes. The notable non-catalytic decrease in toxicity of media containing deoxynivalenol was revealed with luminous cells for both types of tested glucanases, whereas β-glucosidase provided a significant catalytic detoxification of media with aflatoxin B2 and zearalenone at pH 6.0.

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Dose-effect and structure-activity relationships of haloquinoline toxicity towards Vibrio fischeri

Cited by 2 publications

References 38 publications

Ultraviolet-coupled advanced oxidation processes for anti-COVID-19 drugs treatment: Degradation mechanisms, transformation products and toxicity evolution

Ultraviolet-coupled advanced oxidation processes for anti-COVID-19 drugs treatment: Degradation mechanisms, transformation products and toxicity evolution

Luminescent Bacteria as Bioindicators in Screening and Selection of Enzymes Detoxifying Various Mycotoxins

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