Dose-Duration Relationship of Bu1090u by Bolus Injections

Lee, C.; Cheng, M.; Yang, E.; Cantley, E.; Harris, WorsleyJ.; Weakly, J. N.; Whitehead, Bruce

doi:10.1097/00000542-198709001-00353

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Throughout the study period, anaesthetic depth, temperature and endtidal Pco 2 remained stable and the patients received no additional drugs which would interact with the mivacurium. The increasing time interval between doses was a surprising finding, because no evidence of cumulation has been found with mivacurium in other studies [1,7]. However, in these other investigations, fewer doses of mivacurium were administered than in the present study.…”

Section: Discussionsupporting

confidence: 41%

Comparison of the Neuromuscular Block Induced by Mivacurium, Suxamethonium or Atracurium During Nitrous Oxide-Fentanyl Anaesthesia

Caldwell

Heier

Kitts

et al. 1989

British Journal of Anaesthesia

View full text Add to dashboard Cite

We compared the neuromuscular and cardiovascular changes following administration of mivacurium 0.15, 0.20 and 0.25 mg kg-1, suxamethonium 1.0 mg kg-1 or atracurium 0.5 mg kg-1 i.v. in 41 (ASA physical status I or II) patients during nitrous oxide-fentanyl anaesthesia. Mean onset times for total ablation of twitch response for mivacurium 0.15, 0.20 and 0.25 mg kg-1, were 2.5, 2.4 and 2.7 min, respectively, similar to that for atracurium (2.5 min), but longer than for suxamethonium (1.1 min) (P less than 0.05). Mean times from administration of drug until twitch response recovered to 10% of control were shorter for each dose of mivacurium (15.6, 18.0 and 20.6 min, respectively) than for atracurium (40.0 min) and longer than for suxamethonium (7.7 min) (P less than 0.05). Mean infusion rate required to maintain twitch response at 5 +/- 4% control was 6.7 micrograms kg-1 min-1 for mivacurium and 6.3 micrograms kg-1 min-1 for atracurium. Following neostigmine 0.045 mg kg-1, mean times for twitch tension to recover from 10% to 90% of control were similar for mivacurium (9.7 min) and atracurium (10.5 min). Transient decreases in mean arterial pressure (greater than 20%) were observed in seven of 15 patients who received the two higher doses of mivacurium.

show abstract

Section: Discussionsupporting

confidence: 41%

Comparison of the Neuromuscular Block Induced by Mivacurium, Suxamethonium or Atracurium During Nitrous Oxide-Fentanyl Anaesthesia

Caldwell

Heier

Kitts

et al. 1989

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Mivacurium chloride (BW B1090U), a new shortacting non-depolarizing neuromuscular blocking drug, has undergone initial clinical trials to evaluate its neuromuscular and cardiovascular effects [1][2][3][4][5][6][7]. Mivacurium is metabolized by pseudocholinesterase at a rate 70% of that of suxamethonium [8].…”

mentioning

confidence: 99%

Comparison of Mivacurium and Suxamethonium Administered by Bolus and Infusion

Brandom¹,

Woelfel²,

Cook³

et al. 1989

British Journal of Anaesthesia

View full text Add to dashboard Cite

Mivacurium chloride is a new, short-acting nondepolarizing neuromuscular blocking agent presently undergoing clinical evaluation. The neuromuscular effects of mivacurium and suxamethonium given by bolus and infusion were compared in adult patients during nitrous oxide-oxygen-opioid anaesthesia. Neuromuscular block was monitored by recording the compound electromyogram of the adductor pollicis muscle resulting from supramaximal train-of-four stimuli applied to the ulnar nerve. Time to onset of complete block and recovery to T5 were significantly shorter for suxamethonium than for mivacurium (1.0 (0.1) v. 2.5 (0.3) min and 6.4 (0.7) v. 17.5 (1.8) min; mean (SEM]. Conditions for tracheal intubation were similar in the two groups although intubation was performed 0.75-1.3 min later following mivacurium. The infusion rate required to maintain neuromuscular block was 88.6 (10.4) micrograms kg-1 min-1 for suxamethonium and 7.8 (1.2) micrograms kg-1 min-1 for mivacurium. There was a significant negative correlation between recovery to T5 and infusion rate for mivacurium and for suxamethonium. It was equally easy to titrate the infusion rate to the desired degree of block in each group. The recovery index (T25-T75) after the infusion stopped was similar in patients who received mivacurium and those who received suxamethonium.

show abstract

What’s New in Skeletal Muscle Relaxants and Their Antagonists?

Shanks

1988

Anesthesiology Clinics of North America

View full text Add to dashboard Cite

Dose-Duration Relationship of Bu1090u by Bolus Injections

Cited by 3 publications

References 0 publications

Comparison of the Neuromuscular Block Induced by Mivacurium, Suxamethonium or Atracurium During Nitrous Oxide-Fentanyl Anaesthesia

Comparison of the Neuromuscular Block Induced by Mivacurium, Suxamethonium or Atracurium During Nitrous Oxide-Fentanyl Anaesthesia

Comparison of Mivacurium and Suxamethonium Administered by Bolus and Infusion

What’s New in Skeletal Muscle Relaxants and Their Antagonists?

Contact Info

Product

Resources

About