Dose distribution verification in intraoperative radiation therapy using an N-isopropyl acrylamide-based polymer gel dosimeter

Abtahi, Seyed Mohammad Mahdi; Langaroodi, Roghayeh Kargar Shaker; Akbari, Mohammad Esmail

doi:10.1007/s10967-020-07110-y

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…Various studies have analyzed the MRI response of polymer gels for possible application in radiotherapy dose mapping ([ 58 , 63 ] and references therein). In particular, polymer gels have been investigated for dosimetry in conformal therapy, IMRT, IMAT, IGRT, VMAT and tomotherapy [ 55 , 70 , 83 , 88 , 102 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], small photon fields [ 136 , 137 , 138 ], stereotactic radiosurgery [ 55 , 139 , 140 , 141 , 142 ], 60-cobalt source [ 143 , 144 ], brachytherapy [ 55 , 85 , 92 , 145 , ...…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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“…Along with the urgent practical needs, 3D dosimeters including Fricke gels, [5][6][7][8][9] polymer gels, [10][11][12] and radiochromic systems (PRESAGE, 13 tetrazolium salts-based dosimeters, 14 iodide-related gels, 15,16 etc.) have been developed rapidly in recent years.…”

Section: Introductionmentioning

confidence: 99%

Radiation‐sensitive nanogel‐incorporated Fricke hydrogel dosimeters with reduced diffusion rates

Wang

Zhang

et al. 2022

Polymers for Advanced Techs

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Fricke gel dosimeters have great potential for three‐dimensional (3D) dose verification in radiation therapy; however, they suffer from time‐dependent ion diffusion after irradiation, severely affecting their stability and reliability. In this work, a pullulan‐based amphiphilic molecule was synthesized, characterized, and self‐assembled into nanogels. Nanogel structures were embedded into gel dosimeters to reduce the diffusion rates, and radiation‐sensitive nanogel‐incorporated Fricke hydrogel nanocomposites were prepared successfully. The results demonstrated that the diffusion coefficient of improved dosimeters was reduced to 0.125 ± 0.001 mm2 h−1, while maintaining the high optical dose sensitivity (0.0410 ± 0.0004 Gy−1 cm−1). It provides a powerful tool toward the practical application of 3D dosimeters.

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“…During the duration of the period, numerous types of dosimeters are utilized for a variety of purposes, including dyed polymeric thin plastic film dosimeters, which have been widely applied [5][6][7][8][9][10][11]. Liquid dosimeters [12][13][14][15][16][17][18], gel dosimeters [19][20][21][22] and EPR dosimeters [23][24][25]. Upon exposure to irradiation, the physical and chemical properties of the polymers change in the case of films, accordingly due to induced cross-links, chain detachments and formation of new chemical bonds [26].…”

Section: Introductionmentioning

confidence: 99%

Variation in dose response of three dosimetry systems based on diphenyl thiocarbazone

Gafar

El‐Ahdal

El-Shawadfy

2022

J Radioanal Nucl Chem

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Three different dosimetry systems were prepared based on diphenyl thiocarbazone (DTH) dye: polymer films made with, poly(vinyl alcohol), DTH liquid dosimeter and DTH gel dosimeter. All the systems received several gamma doses. The three systems were analyzing by UV–Vis spectrophotometery before and after irradiation. The effective dose range in the linear part of these systems is between 1–10 kGy, 0.3–2 kGy, and 50–200 Gy. The dose range of these three dosimeters relies on the concentration of DTH. The radiation chemical yield (G-value) was determined for the three prepared dosimeters, and all three radiation dosimeters were examined before and after irradiation.

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Dose distribution verification in intraoperative radiation therapy using an N-isopropyl acrylamide-based polymer gel dosimeter

Cited by 10 publications

References 29 publications

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Radiation‐sensitive nanogel‐incorporated Fricke hydrogel dosimeters with reduced diffusion rates

Variation in dose response of three dosimetry systems based on diphenyl thiocarbazone

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