Dose dependent toxicity of glutamic acid: a review

Abstract

L-glutamate, the major neurotransmitter in humans, becomes excitotoxic when present outside of protein in excess of what the healthy human was designed to accommodate; amounts readily available to consumers who ingest multiple free-glutamate-containing ingredients during a day. Studies have demonstrated that excitotoxins ingested by a mother will pass to the fetus across the placenta and pass to the newborn through mothers' milk. The purpose of this paper is to raise awareness of the relevance of glutamate from food additives such as MSG to human brain damage, and its possible contributions to glutamate toxicity in neurodegenerative diseases

Marsilea crenata ethanol extract prevents monosodium glutamate adverse effects on the serum levels of reproductive hormones, sperm quality, and testis histology in male rats

“…Monosodium glutamate (MSG) is commonly used as a food additive or as a flavor enhancer [ 1 ]. MSG is used to improve the taste of salty, sweet, sour, and bitter foods, which is known as umami taste [ 2 ].…”

Amino Acids in New Organic Fertilizer AnchoisFert

“…[19] In plants, alanine is accumulated as a generic stress response molecule involved in protecting plants from temperature extremes, hypoxia, drought, as well as chemical and biotic stresses. [20] Glutamic acid is the major neurotransmitter in humans, though it becomes toxic when present outside of protein in excess to dose healthy human can accommodate [21] (it is widely added as taste enhancer to many foods as sodium glutamate). Again, glutamate has a key signaling role in plants being involved in amino acid metabolism, and was recently found to reshape the plant microbial community protecting plants against pathogens.…”

Variations in fatty acid and amino acid profiles of doi and rasomalai made from buffalo milk

“…Among the AAs, glutamic acid concentrations were found to be greater in both products, with doi containing 0.2 gm more glutamic acid than rasomalai. This AA may be significant for human health because glutamic acid is essential for the normal functioning of the human body as a protein ingredient and neurotransmitter [ 33 ]. Mohania et al [ 34 ] claim that doi is a functional diet for humans due to its medicinal and nutritional properties.…”