Dose-Dependent Pulmonary Injury Following Nitrogen Dioxide Inhalation From Kinepak™ Detonation

et al. 2020

BMC Public Health

Background: Previous studies have suggested that there is an association between air pollutants and circulatory and respiratory diseases; however, relatively few have analyzed the association between air pollutants and outpatient visits based on the mortality, hospitalization rates, etc., especially in areas with relatively good air quality. Therefore, we conducted this study to research the association between air pollutants and outpatient visits in Fuzhou, China. Methods: We used a generalized linear Poisson model to study the association between air pollution and outpatient visits for respiratory and circulatory diseases from 2016 to 2018 in Fuzhou, China. Results: In the single pollutant model, nitrogen dioxide (NO 2) had a significant effect. For lag day 0 to lag day 5, the effect decreased with every 10 μg/L increase in NO 2. The daily maximum 8-h mean ozone (O 3-8h) and upper respiratory outpatient visits were positively associated during the cold period [lag2, excess risk (ER) (95% confidence interval (CI)): 1.68% (0.44-2.94%)], while O 3-8h and respiratory disease were positively associated during the warm period [lag5, ER (95% CI): 1.10% (0.11-2.10%) and lag4, ER (95% CI): 1.02% (0.032-2.02%)]. Similarly, particulate matter (PM) with an average aerodynamic diameter of less than 10 μm (PM 10) and lower respiratory diseases were positively associated during the warm period [lag0, ER (95% CI): 1.68% (0.44-2.94%)]. When the concentration of O 3-8h was higher than 100 μg/L, there was a positive effect on circulatory [lag5, ER (95% CI): 2.83% (0.65-5.06%)], respiratory [lag5, ER (95% CI): 2.47% (0.85-4.11%)] and upper respiratory [lag5, ER (95% CI): 3.06% (1.38-4.77%)] outpatient visits. The variation in O 3-8h changed slightly when we adjusted for other air pollutants, and after adjusting for O 3-8h, the ERs of the other air pollutants changed slightly. After adjusting for PM with an average aerodynamic diameter of less than 2.5 μm (PM 2.5), the ERs of the other air pollutants increased, and after adjusting for NO 2 , the ER of PM decreased.

Section: Discussionmentioning

confidence: 99%

Temporal cross-correlations between air pollutants and outpatient visits for respiratory and circulatory system diseases in Fuzhou, China

et al. 2020

BMC Public Health

“…During the cold season, the concentration of NO 2 was 33.11 μg/m 3 , while during the warm season, it was 23.32 μg/m 3 . There is a dose-dependent relationship between pulmonary injuries and ambient NO 2 [36], but for circulatory injuries, there is a lack of research. Interestingly, NO 2 , O 3 , PM 2.5 and PM 10 had similar results in terms of their influences on outpatient visits for upper and lower respiratory diseases.…”

Section: Discussionmentioning

confidence: 99%

Temporal cross-correlations between air pollutants and outpatient visits for respiratory and circulatory system diseases in Fuzhou, China

et al. 2020

Preprint

Background: Previous studies have suggested that there is an association between air pollutants and circulatory and respiratory diseases, but relatively few have analyzed the association between air pollutants and outpatient visits considering mortality, hospitalization rates, etc., especially areas with relatively good air quality. Therefore, we conducted this study to research the association between air pollutants and outpatient visits in Fuzhou, China. Methods: We used a generalized linear Poisson model to study the association between air pollution and outpatient visits for respiratory and circulatory diseases during 2016-2018 in Fuzhou, China. Results: In the single pollutant model, nitrogen dioxide (NO2) had a significant effect. For lag day 0 to lag day 5, the effect decreased with every 10 µg/L increase in NO2. Daily maximum 8-h mean ozone (8-h O3) and upper respiratory outpatient visits were positively associated during the cold period [lag2, excess risk (ER) (95% confidence interval (CI)): 1.68% (0.44%-2.94%)], while 8-h O3 and respiratory disease were positively associated during the warm period [lag5, ER (95% CI): 1.10% (0.11%-2.10%) and lag4, ER (95% CI): 1.02% (0.032%-2.02%)]. Similarly, particulate matter (PM) with an average aerodynamic diameter of less than 10 μm (PM10) and lower respiratory diseases were positively associated during the warm period [lag0, ER (95% CI): 1.68% (0.44%-2.94%)]. When the concentration of 8-h O3 was higher than 100 μg/L, there was a positive effect on circulatory [lag5, ER (95% CI): 2.83% (0.65%-5.06%)], respiratory [lag5, ER (95% CI): 2.47% (0.85%-4.11%)] and upper respiratory [lag5, ER (95% CI): 3.06% (1.38%-4.77%)] outpatient visits. The variation in 8-h O3 changed slightly when we adjusted for the other air pollutants, and after adjusting for 8-h O3, the ERs of the other air pollutants changed slightly. After adjusting for PM with an average aerodynamic diameter of less than 2.5 μm (PM2.5), the ERs of the other air pollutants increased, and after adjusting for NO2, the ER of PM decreased. Conclusion: Exposure to ambient NO2, O3, PM2.5 and PM10 was associated with an increase in respiratory and circulatory system-related outpatient visits in Fuzhou, China.

“…In the cold period, the concentration of NO 2 was 33.11 μg/m 3 , while in the warm period, it was 23.32 μg/m 3 . There is a dose-dependent relationship between pulmonary injuries and ambient NO 2 [33], but for circulatory injuries, there is a lack of research. Interestingly, NO 2 , O 3 , PM 2.5 and PM 10 had similar results, in term of influences on upper and lower respiratory outpatient visits.…”

Section: Discussionmentioning

confidence: 99%

Temporal Cross-Correlations between air pollutants and outpatient visits for respiratory and circulatory system diseases in coastal area of China

et al. 2019

Preprint

Background Some previous studies have suggested that there is an association between air pollutants and circulatory and respiratory diseases. However, the association of air pollutants and outpatient visits considering mortality, hospitalization rates, etc. has been analyzed in relatively few studies.Methods We used a generalized linear Poisson model was constructed to study the association between air pollution and outpatient visits for respiratory and circulatory diseases during 2016-2018 in coastal area of China.Results In the single pollutant model, NO 2 had a significant effect. For lag day 0 to lag day 5, the effect decreased with every 10 µg/L increase in NO 2 . O 3 and upper respiratory outpatient visits were positively associated in the cold period [lag2, ER (95%CI): 1.68% (0.44%-2.94%)], while O 3 and respiratory disease were positively associated in the warm period [lag5, ER (95%CI): 1.10% (0.11%-2.10%) and lag4, ER (95%CI): 1.02% (0.032%-2.02%)]. Similarly, PM 10 and lower respiratory diseases were positively associated in the warm period [lag0, ER (95%CI): 1.68% (0.44%-2.94%)]. When the concentration of O 3 was higher than 100 μg/L, there was a positive effect on circulatory [lag5, ER (95%CI): 2.83% (0.65%-5.06%)], respiratory [lag5, ER (95%CI): 2.47% (0.85%-4.11%)] and upper respiratory [lag5, ER (95%CI): 3.06% (1.38%-4.77%)] outpatient visits. The variation in O 3 changed slightly when we adjusted for the other air pollutants, and after adjusting for O 3 , the ERs of the other air pollutants changed slightly. After adjusting for PM 2.5 , the ER of the other air pollutants increased, and after adjusting for NO 2 , the ER of particulate matter (PM) decreased.Conclusion Exposure to ambient NO 2 , O 3 , PM 2.5 and PM 10 was associated with an increase in respiratory and circulatory system outpatient visits in coastal area of China.