Dose-dependent effects of strontium on bone of chronic renal failure rats

Schrooten, Iris; Behets, Geert J.; Cabrera, Walter; Vercauteren, Sven R.; Lamberts, Ludwig V.; Verberckmoes, Steven; Bervoets, A.J.; Dams, Geert; Goodman, William G.; Broe, Marc E. De; D’Haese, Patrick C.

doi:10.1046/j.1523-1755.2003.00809.x

Cited by 65 publications

(51 citation statements)

References 27 publications

(13 reference statements)

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“…Objective 10x. © C I C E d i z i o n i I n t e r n a z i o n a l i chemical crystal properties (37,38). Our finding agree with previous data obtained by our research group, according to which strontium can distinctly induce proliferation or mineralization activity on human adipose tissue-derived mesenchymal stem cells, according to the used high or low concentrations (10).…”

Section: Discussionsupporting

confidence: 90%

The effect of strontium chloride on human periodontal ligament stem cells

Romagnoli

Zonefrati

Galli

et al. 2017

ccmbm

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SummaryThe complete repair of periodontal structures remains an exciting challenge that prompts researchers to develop new treatments to restore the periodontium. Recent research has suggested strontium ion to be an attractive candidate to improve osteogenic activity. In this study, we have isolated a clonal finite cell line derived from human periodontal ligament (PDL) in order to assess whether and in which way different doses of SrCl2 (from 0.5 to 500 μg/ml) can influence both the proliferation and the mineralization process, for future application in oral diseases. PDL cells were cloned by dilution plating technique and characterized by FACS. Cell proliferation analysis and mineralization were performed by [ 3 H]-thymidine incorporation and spectrofluorometric assay. Results have evidenced that the higher SrCl2 concentrations tested, from 25 to 500 μg/ml, have increased the proliferation activity after only 24 h of treatment. Interestingly, the same higher concentrations have decreased the mineralization, which was conversely increased by the lower ones, from 0.5 to 10 μg/ml. Our findings suggest the possible use of SrCl2 in appropriate delivery systems that release, at different time points, the specific dose, depending on the biological response that we want to induce on periodontal ligament stem cells, providing a more efficient periodontal regeneration.

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Section: Discussionsupporting

confidence: 90%

The effect of strontium chloride on human periodontal ligament stem cells

Romagnoli

Zonefrati

Galli

et al. 2017

ccmbm

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“…In many instances, the pathogenesis of the precise type of ROD in a given patient seems to be obvious, for instance secondary hyperparathyroidism for osteitis fibrosa, vitamin D deficiency or aluminum overload for osteomalacia, hypoparathyroidism for adynamic bone disease, and advanced age and female gender for osteoporosis. However, other factors may also play a role, including abnormal levels or functions of hormones involved in mineral metabolism (other than parathyroid hormone [PTH] and calcitriol), in gonadal function, or in energy metabolism (in particular diabetes) (7); abnormal growth factors or cytokine levels and dysfunction of their receptors (8,9); acidosis (10); oxidative stress and advanced glycation end products (11); uremic toxins (12,13); metal overload (14,15); insufficient mechanical loading (8); and inappropriate diets and malnutrition (16,17). A better understanding, at the patient level and the molecular level, of the underlying pathogenesis and the risk factors involved in ROD including osteoporosis might help to prevent this important health problem in the patient population with CKD (6).…”

mentioning

confidence: 99%

Sclerostin

Drüeke¹,

Lafage-Proust²

2011

Clinical Journal of the American Society of Nephrology

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“…In the long run, this may decrease skeletal calcium content. Besides being incorporated into hydroxyapatite, Sr can be adsorbed at the crystal surface and was shown to inhibit subsequent crystal growth [11,12,26,27] . Beyond these effects on apatite formation, Sr was shown to interfere with osteoblast differentiation in vitro already at low extracellular concentrations [28] .…”

Section: Discussionmentioning

confidence: 99%

“…In experimental uremia, high dosages of Sr induce mineralization defects and osteomalacia [11,12] . Likewise, osteomalacia in CKD patients on hemodialysis has been strongly associated with the Sr concentration in dialysis fluids and probably additional effects related to Sr-contaminated phosphate binders [7,13] .…”

Section: Moderate Strontium Loading Induces Rickets In Rats With Mildmentioning

confidence: 99%

Moderate Strontium Loading Induces Rickets in Rats with Mild Chronic Renal Failure

Fischer

Jensen²,

Rahn³

et al. 2011

Kidney Blood Press Res

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Background/Aims: Renal osteodystrophy and eventually osteoporosis are serious long-term complications in children with end-stage renal disease before and after renal transplantation. Strontium (Sr) salts are used for treatment of osteoporosis in adults. Methods: To evaluate the time-dependent effects of Sr on growth plate morphology and their reversibility, chronic renal failure (CRF) rats received either normal or Sr-loaded drinking water (2 g/l; ±200 mg/kg/day) for periods of 2, 6 and 12 weeks with or without subsequent washout periods of 0, 2, 4 or 8 weeks. Results: While weight gain was not affected by Sr loading, a significant enlargement of the entire growth plate, mainly due to expansion of the hypertrophic zone, was already present after 2 weeks. Sr-loaded animals showed increased osteoid areas and reduced bone formation rates at 2, 6 and 12 weeks compared to controls. This was accompanied by reduced PTH levels and increased serum bone alkaline phosphatase activity. After the washout periods these effects were reversed. In general, the height of the hypertrophic zone was positively correlated with osteoid area and negatively correlated with bone formation rate. Conclusion: Moderate Sr loading in CRF rats results in rapid development of rickets, which is reversible after washout.

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Dose-dependent effects of strontium on bone of chronic renal failure rats

Abstract: Our findings indicate that the role of Sr in the development of bone lesions in renal failure is complex and that, depending on the dose, the element may act via multiple pathways.

Cited by 65 publications

References 27 publications

The effect of strontium chloride on human periodontal ligament stem cells

The effect of strontium chloride on human periodontal ligament stem cells

Sclerostin

Moderate Strontium Loading Induces Rickets in Rats with Mild Chronic Renal Failure

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