Dose-dependent effects of mosapride citrate on duodenal and cecal motility in donkeys (<i>Equus asinus</i>)

Gomaa, Naglaa; Ibrahim, Hussam; Ishii, Mitsuo; Nassif, Medhat N.; El-Khodery, Sabry

doi:10.1016/j.ijvsm.2013.09.001

Cited by 10 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anatomical location and the ultrasonographic presence of the visualized sections of both the small and large intestine using abdominal ultrasonography agreed with those previously described [ 28 , 29 ]. Before IV injection of normal isotonic saline or different selected doses of dexmedetomidine in the donkeys under study, the regularity of contractility of both small (duodenum and jejunum) and large (left colon, right colon, and cecum) intestines were within normal ranges, which are directly comparable those reported by [ 23 , 28 , 30 ]. The IV injection of isotonic saline solution in the donkeys did not influence the contractility of the visualized sections of the small and large intestine during 120 minutes motoring period and stayed inside the ordinary varies till 120 minutes post-injection as formerly described in humans [ 31 ].…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

et al. 2022

View full text Add to dashboard Cite

Aim Gastrointestinal effects of different doses of dexmedetomidine in donkeys are still unidentified. The current study aimed to evaluate the impact of different doses of dexmedetomidine on the motility of selected parts of the gastrointestinal tracts in donkeys using transabdominal ultrasonography. Materials and methods An experimental crossover study was conducted on 30 healthy donkeys of both sexes (15 males and 15 females; 160 ± 60 kg). With a two-week washout period, each donkey received an injection of either a normal saline solution or three different doses of dexmedetomidine (3, 5, and 7 μg/kg, respectively). All medications were administered intravenously in equal volumes. The contractility of selected intestinal segments (duodenum, jejunum, left colon, right colon, and cecum) was measured 3 min before administration (zero time) and at 15, 30, 45, 60, 90, and 120 minutes after administration. Results Small and large intestinal motility was within the normal ranges before IV injection of normal isotonic saline or dexmedetomidine at a dose of 3, 5, and 7 μg/kg. Two Way Repeated Measures ANOVA output of the data displayed a statistically significant the between time and treatments for the contractility of each of the duodenum (P = 0.0029), jejunum (P = 0.0033), left colon (P = 0.0073), right colon (P = 0.0035), and cecum (P = 0.0026), implying that the impact of treatment on the gastric motility varied among different time points. The simple main effect analysis revealed that the IV dexmedetomidine at 3, 5, and 7 μg/kg doses significantly inhibited (P ≤ 0.01) the bowel contractility compared to the administration of isotonic saline. Conclusion Dose-dependent inhibitory effect of dexmedetomidine on intestinal motility was reported in donkeys following intravenous administration. This inhibitory effect on intestinal motility should be considered in clinical practice.

show abstract

Section: Discussionsupporting

confidence: 85%

“…The frequency of duodenal, jujenum, left colon, right colon and cecal contractions in donkeys are closely similar reported in horses [ 21 , 22 ] and in the perivous study in [ 23 ].…”

Section: Discussionsupporting

confidence: 83%

Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The anatomical location and the ultrasonographic presence of the visualized sections of both the small and large intestine using abdominal ultrasonography agreed with those previously described [18,19]. Before IV injection of normal isotonic saline or different selected doses of dexmedetomidine in the donkeys under trials, the regularity of contractility of both small (duodenum and jejunum) and large (left colon, right colon, and cecum) intestines were inside the ordinary varies, which are directly comparable those informed by [18,20,21].IV injection of isotonic saline solution in the donkeys did not in uence the contractility of the visualized sections of the small and large intestine during 120th min motoring period and stayed inside the ordinary varies till 120th min post-injection as formerly described in humans [22].…”

Section: Discussionsupporting

confidence: 89%

Evaluation of the efficacy of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

Abass

Ibrahim

Salcı

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: The gastrointestinal effects of different doses of dexmedetomidine in donkeys are unknown. The study aimed to assess the impacts of different doses of dexmedetomidine on the motility of selected parts of the gastrointestinal tracts in donkeys using trans-abdominal ultrasonography. In-vivo experiment, a thirty healthful donkey of both sex (fifteen males and fifteen females;160 ± 60 kg) received either normal saline solution or three different doses of dexmedetomidine (3, 5, 7 µg/kg) within two weeks washout period. All medications were given intravenously in equal volumes. The contractility of selected intestinal segments (duodenum, jejunum, left colon, right colon, and cecum) was totaled for three min before administration (zero time) and at 15, 30, 45, 60, 90, and 120 min after administration. Results: There were no detectable clinical abnormalities on all selected donkeys, and they remained clinically healthy throughout the study period. Intravenous administration of dexmedetomidine markedly inhibited the small and large intestine motility when compared with saline treatment. The existing study revealed that Intravenous administration of dexmedetomidine reduces donkeys' small and large intestinal motility. Conclusion: Intravenous administration of dexmedetomidine is a suitable sedative drug for donkeys when sedation and analgesia are needed for very short periods.

show abstract

“…Prokinetics are effective agents in the treatment of diseases with diminished bowel motility and POI cases [ 6 ]. These agents enhance GI motility by increasing the frequency of intestinal contractions or making them stronger [ 7 ]. A variety of prokinetic agents has been used in horses with varying success.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic evaluation of the effects of the administration of neostigmine and metoclopramide on duodenal, cecal, and colonic contractility in Arabian horses: A comparative study

2020

View full text Add to dashboard Cite

Background and Aim: As means for enhancing gastrointestinal (GI) motility, prokinetics have previously been evaluated in different breeds of horses with varying success. No previous studies were conducted to evaluate the effect of prokinetics on the intestinal tract of Arabian horses breed. Using B-mode ultrasound in the quantification of intestinal contractility, this study aimed to compare the impact of neostigmine and metoclopramide on the intestinal motility of healthy Arabian horses. Materials and Methods: Twenty-one clinically healthy Arabian horses were equally distributed into three groups. The control group was administered with 5 mL normal saline intramuscularly (IM). The second group was administered with neostigmine (0.044 mg/kg body weight [BW], IM), and the third group was administered with metoclopramide (0.25 mg/kg BW, IM). Duodenal, cecal, and colonic contractions were counted through ultrasonography for 3 min (pre-administration and 15, 30, 60, 120, and 180 min post-administration). Results: In the neostigmine group, a significant (p<0.05) increase in duodenal, cecal, and colonic contractions was observed 15 min post-administration compared with that in the control group (15±1.0, 11.33±1.53, and 12.33±2.31 vs. 11.0±2.0, 6.33±0.58, and 5.33±0.58 contractions per 3 min, respectively), continuing to 60 min post-administration for the duodenum and cecum and 120 min for colon and then returning to the normal; however, the metoclopramide group showed a significant (p<0.05) increase only in cecal and colonic contractions 60 min post-administration compared with the control group (11.0±1.0 and 12.33±0.58 vs. 6±1.0 and 5.67±0.58 contractions per 3 min, respectively), continuing until the end of the experiment. Excessive sweating, excitation, and straining were recorded following the administration of neostigmine, whereas no side effects were observed in the metoclopramide group. Conclusion: Neostigmine improves duodenal, cecal, and colonic contractions in healthy adult Arabian horses, whereas metoclopramide only improves cecal and colonic contractions. Metoclopramide appears to be safer and longer acting than neostigmine in the Arabian horse breed. Ultrasonography is a valuable noninvasive tool for the quantification of intestinal contractility. Future studies should consider the use of various dosages of metoclopramide and administration routes and investigate its impact on horses with GI transit disorders and inclusion in colic post-operative care.

show abstract

Dose-dependent effects of mosapride citrate on duodenal and cecal motility in donkeys (Equus asinus)

Cited by 10 publications

References 24 publications

Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

Evaluation of the efficacy of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)

Ultrasonographic evaluation of the effects of the administration of neostigmine and metoclopramide on duodenal, cecal, and colonic contractility in Arabian horses: A comparative study

Contact Info

Product

Resources

About